Results 131 to 140 of about 16,097 (238)

Extracellular Vesicles from UVB Irradiated Keratinocytes Contain Cyclobutane Pyrimidine Dimers

, 2021
Ultraviolet (UV) radiation induces the formation of cyclobutane pyrimidine dimers (CPDs) in genomic DNA, which are normally removed by nucleotide excision repair. However, the fate of these adducts remain largely unexplored.
Ginugu, Meghana Reddy
core  

DNA excision repair: Where do all the dimers go?

, 2012
Exposure of cells to UV light from the sun causes the formation of pyrimidine dimers in DNA that have the potential to lead to mutation and cancer. In humans, pyrimidine dimers are removed from the genome in the form of ~30 nt-long oligomers by concerted
Sancar, Aziz, Kemp, Michael G.
core   +1 more source

Persicaria tinctoria Extract Mitigates UV-Associated DNA Damage and Inflammation, While Boosting Vitamin D3 and Melanin in Human Skin

Cosmetics
Benefit/risk management of skin exposure to sunlight, especially ultraviolet (UV) rays, is mainly driven by photoaging, cancer incidence, and the requirement for vitamin D3 synthesis.
Morgane de Tollenaere, Catherine Zanchetta, Anaïs Durduret, Jessy Martinez, Bénédicte Sennelier-Portet, Jean Tiguemounine, Amandine Scandolera, Romain Reynaud   +7 more
doaj   +1 more source

All You Need Is Light. Photorepair of UV-Induced Pyrimidine Dimers. [PDF]

Genes (Basel), 2020
Banaś AK, Zgłobicki P, Kowalska E, Bażant A, Dziga D, Strzałka W.   +5 more
europepmc   +1 more source

UVA-induced cyclobutane pyrimidine dimers in DNA: a direct photochemical mechanism?

, 2010
International audienceThe carcinogenic action of UVA radiation is commonly attributed to DNA oxidation mediated by endogenous photosensitisers. Yet, it was recently shown that cyclobutane pyrimidine dimers (CPD), well known for their involvement in UVB ...
Philippe, C., Banyasz, A., Markovitsi, D., Karpati, S., Mouret, S., Gracia-Chantegrel, J., Douki, Thierry   +6 more
core   +1 more source

Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks

, 2005
Photolyase transgenic mice have opened new avenues to improve our understanding of the cytotoxic effects of ultraviolet (UV) light on skin by providing a means to selectively remove either cyclobutane pyrimidine dimers (CPDs) or pyrimidine (6-4 ...
Hoeijmakers, J.H.J. (Jan), Hanada, K. (Katsuhiro), Kanaar, R. (Roland), Garinis, G.A. (George), Spek, P.J. (Peter) van der, Mitchell, J.R. (James), Moorhouse, M.J. (Michael), Brand, K. (Karl), Smid, M. (Marcel), Waard, H. (Harm) de, Jans, J. (Judith), Vandeputte, D. (Dimitri), Horst, G.T.J. (Gijsbertus) van der   +12 more
core   +1 more source

UVA1 Induces Cyclobutane Pyrimidine Dimers but Not 6-4 Photoproducts in Human Skin In Vivo

, 2012
UVB readily induces cyclobutane pyrimidine dimers, mainly thymine dimers (TTs), and pyrimidine (6-4) pyrimidone photoproducts (6-4PPs) in DNA. These lesions result in “UVB signature mutations” found in skin cancers.
Sarkany, Robert P., Young, Antony R., Antony R. Young, Young, Antony, Tewari, Angela, Angela Tewari, Robert P. Sarkany   +6 more
core   +1 more source

Pyrimidine Dimer [PDF]

, 2020
openaire   +1 more source

Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation

, 2006
International audienceSolar UV radiation is the most important environmental factor involved in the pathogenesis of skin cancers. The well known genotoxic properties of UVB radiation (290-320 nm) mostly involve bipyrimidine DNA photoproducts. In contrast,
A. Favier, Baudouin, C., S. Mouret, M. Charveron, Charveron, M., Cadet, J., J. Cadet, Favier, A., T. Douki, Mouret, S., Douki, Thierry, C. Baudouin   +11 more
core   +1 more source

In vivo induction of pyrimidine dimers in human skin by UVA radiation: initiation of cell damage and/or intercellular communication?

, 1999
Pyrimidine dimers participate as important factors in ultraviolet-induced lethality, mutagenicity and tumorgenicity. Substantial efforts have been made in recent years to understand the induction of pyrimidine photodimers and their repair in human skin ...
Applegate, L. A., Niggli, H., Panizzon, R., Frenk, E., Scaletta, C.   +4 more
core