Results 1 to 10 of about 68,708 (233)
Studies in pyrimidine metabolism [PDF]
Journal of Biological Chemistry, 1920 By partial hydrolysis of yeast nucleic acid, preparations containing pyrimidines as the only nitrogenous constituents were prepared and administered to rabbits. Uracil nucleoside when administered per os, subcutaneously or intraperitoneally caused an increased excretion of urea often much more than enough to account for the nitrogen administered.
Darrell M. Wilson
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A Search for Interstellar Pyrimidine [PDF]
Mon.Not.Roy.Astron.Soc.345:650,2003, 2003 We have searched three hot molecular cores for submillimeter emission from the nucleic acid building-block pyrimidine. We obtain upper limits to the total pyrimidine (beam-averaged) column densities towards Sgr B2(N), Orion KL and W51 e1/e2 of 1.7E+14 cm^{-2}, 2.4E+14 cm^{-2} and 3.4E+14 cm^{-2}, respectively.
H. C. Huang +6 more
arxiv +5 more sources
Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects [PDF]
PharmaceuticalsPyrimidine is a moiety that occurs in living organisms and has a variety of significant biological properties in pharmacology. Due to the easy handling of synthesis, easily available precursor, and less duration for the reaction, for the synthesis, not ...
Katharigatta N. Venugopala, Vinuta Kamat
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Pharmaceuticals, 2022 The objective of this review is to list the structures composed of a pyridopyrimidine moiety which have shown a therapeutic interest or have already been approved for use as therapeutics.
Joana F. Campos +2 more
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The study of the apoptogenic effect of pyrimidine derivatives on murine leukemia cells [PDF]
Archive of Oncology, 2005 BACKGROUND: In the light of the recent findings concerning the role of apoptosis and of tumor cell enzymes in cancer chemotherapy, the interest in pyrimidine derivatives has greatly increased.
Gorneva Galina +3 more
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Beilstein Journal of Organic Chemistry, 2021 The concise preparation of 4,4,4-trifluorobut-2-yn-1-ones by the oxidation of the readily accessible corresponding propargylic alcohols as well as their utilization as Michael acceptors for the construction of aromatic and heteroaromatic compounds are ...
Takashi Yamazaki +3 more
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REVIEW OF PYRIMIDINE DERIVATIVES AS PHARMACOLOGICALLY ACTIVE COMPOUNDS
Juvenis Scientia, 2022 Pyrimidine derivatives represent an extensive class of organic compounds that contain in their structure a six-membered heterocycle with two nitrogen atoms at positions 1 and 3.
A. S. Chiriapkin
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A New Class of Uracil–DNA Glycosylase Inhibitors Active against Human and Vaccinia Virus Enzyme
Molecules, 2021 Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The activity of Family 1 uracil–DNA glycosylase (UNG) activity limits the efficiency of
Inga R. Grin +10 more
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Molecules, 2021 Enterococcus faecalis is known as a significant nosocomial pathogen due to its natural resistance to many antibacterial drugs. Moreover, it was found that E. faecalis infection causes inflammation, production of reactive oxygen species, and DNA damage to
Marcin Stolarczyk +6 more
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Molecules, 2002 Syntheses of several novel 4-chloropyrrolo[2,3-d]pyrimidines (1), 4-hydrazinopyrrolo[2,3-d]pyrimidines (2) and 3-amino-4-iminopyrrolo[2,3-d]pyrimidines (7) and their use in the synthesis of tetrazolo[1,5-c]pyrrolo[3,2-e]pyrimidines (3) and triazolo[1,5-c]
Rina D. Shah, Chaitanya G. Dave
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