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Skeletal Editing of Pyrimidines to Pyrazoles by Formal Carbon Deletion
Journal of the American Chemical Society, 2022 A method for the conversion of pyrimidines into pyrazoles by a formal carbon deletion has been achieved guided by computational analysis. The pyrimidine heterocycle is the most common diazine in FDA-approved drugs, and pyrazoles are the most common ...
Richmond Sarpong
exaly +2 more sources
RSC Advances, 2021 Pyrimidines are aromatic heterocyclic compounds that contain two nitrogen atoms at positions 1 and 3 of the six-membered ring. Numerous natural and synthetic pyrimidines are known to exist.
Adriana Pereira Duarte +2 more
exaly +2 more sources
Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects [PDF]
PharmaceuticalsPyrimidine is a moiety that occurs in living organisms and has a variety of significant biological properties in pharmacology. Due to the easy handling of synthesis, easily available precursor, and less duration for the reaction, for the synthesis, not ...
Katharigatta N. Venugopala, Vinuta Kamat
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Studies in pyrimidine metabolism [PDF]
Journal of Biological Chemistry, 1920 By partial hydrolysis of yeast nucleic acid, preparations containing pyrimidines as the only nitrogenous constituents were prepared and administered to rabbits. Uracil nucleoside when administered per os, subcutaneously or intraperitoneally caused an increased excretion of urea often much more than enough to account for the nitrogen administered.
Darrell M. Wilson
openalex +5 more sources
A Search for Interstellar Pyrimidine [PDF]
Mon.Not.Roy.Astron.Soc.345:650,2003, 2003 We have searched three hot molecular cores for submillimeter emission from the nucleic acid building-block pyrimidine. We obtain upper limits to the total pyrimidine (beam-averaged) column densities towards Sgr B2(N), Orion KL and W51 e1/e2 of 1.7E+14 cm^{-2}, 2.4E+14 cm^{-2} and 3.4E+14 cm^{-2}, respectively.
H. C. Huang +6 more
arxiv +5 more sources
Pharmaceuticals, 2022 The objective of this review is to list the structures composed of a pyridopyrimidine moiety which have shown a therapeutic interest or have already been approved for use as therapeutics.
Joana F. Campos +2 more
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An overview on synthesis and biological activity of pyrimidines
World Journal of Advanced Research and Reviews, 2022 Pyrimidines represent an important class of heterocycles containing two nitrogen atoms at position 1 and 3 of the six membered ring show wide range of biological activities.
N. A. A. El-tawab +5 more
semanticscholar +1 more source
Molecules, 2021 Pyrazolo[1,5-a]pyrimidine (PP) derivatives are an enormous family of N-heterocyclic compounds that possess a high impact in medicinal chemistry and have attracted a great deal of attention in material science recently due to their significant ...
Andres Arias-Gómez +2 more
semanticscholar +1 more source
The study of the apoptogenic effect of pyrimidine derivatives on murine leukemia cells [PDF]
Archive of Oncology, 2005 BACKGROUND: In the light of the recent findings concerning the role of apoptosis and of tumor cell enzymes in cancer chemotherapy, the interest in pyrimidine derivatives has greatly increased.
Gorneva Galina +3 more
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Beilstein Journal of Organic Chemistry, 2021 The concise preparation of 4,4,4-trifluorobut-2-yn-1-ones by the oxidation of the readily accessible corresponding propargylic alcohols as well as their utilization as Michael acceptors for the construction of aromatic and heteroaromatic compounds are ...
Takashi Yamazaki +3 more
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