Simple oxidation of pyrimidinylhydrazones to triazolopyrimidines and their inhibition of Shiga toxin trafficking [PDF]
, 2010 The oxidative cyclisation of a range of benzothieno[2,3-d]pyrimidine hydrazones (7a–j) to the 1,2,4-triazolo[4,3-c]pyrimidines (8a–j) catalysed by lithium iodide or to the 1,2,4-triazolo[1,5-c]pyrimidines (10a–j) with sodium carbonate is presented.
Ahmed +46 more
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Synthesis of Pyrimidines and Condensed Pyrimidines [PDF]
Bulletin of the Chemical Society of Japan, 1973 Abstract A new one-step synthesis of pyrimidines and condensed pyrimidines by heating carboxamides or cyclic lactams with formamide in the presence of POCl3 in a sealed tube is described.
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Diversity oriented synthesis : substitution at C5 in unreactive pyrimidines by Claisen rearrangement and reactivity in nucleophilic substitution at C2 and C4 in pteridines and pyrido[2,3-d]pyrimidines [PDF]
, 2011 Diversity oriented synthesis of fused pyrimidines leads to scaffolds with many biological activities. In the case of the preparation of pyrido[2,3-d]pyrimidines from 2-alkylthiopyrimidines, the formation of a new carbon-carbon bond at C5 is required, a ...
Adcock, Jonathan Paul +3 more
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Synthesis of 2-Substituted 9-Oxa-Guanines {5-Aminooxazolo 5,4-D Pyrimidin-7(6H)-Ones} and 9-Oxa-2-Thio-Xanthines{5-Mercaptooxazolo 5,4-D Pyrimidin-7(6H)-Ones} [PDF]
, 2008 Oxazolo[5,4-d] pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives.
Bai, Yan +4 more
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PURINE AND PYRIMIDINE ANTAGONISM IN A PYRIMIDINE-DEFICIENT MUTANT OF NEUROSPORA [PDF]
Journal of Biological Chemistry, 1948 The present study is concerned with the inhibition of growth of the pyrimidine-deficient Neurospora mutant, No. 1298, by the naturally occurring purine ribonucleotides and ribonucleosides. This experimentally produced strain, unlike the wild type, is unable to synthesize the pyrimidine ribonucleosides on a medium containing inorganic salts ...
Pierce, John G., Loring, Hubert S.
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Revisiting the structure and chemistry of 3(5)-Substituted Pyrazoles [PDF]
, 2019 Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry, often used as starting materials for the preparation of more complex heterocyclic systems with relevance in the pharmaceutical field.
Alam +34 more
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SPIRO-PYRIMIDINES. II. CYCLOHEXANE-1,5-SPIRO-PYRIMIDINES. [PDF]
Journal of the American Chemical Society, 1921 n ...
Dox, Arthur W., Yoder, Lester
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Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase [PDF]
, 2009 hSMUG1 (human single-stranded selective monofunctional uracil-DNA glyscosylase) is one of three glycosylases encoded within a small region of human chromosome 12. Those three glycosylases, UNG (uracil-DNA glycosylase), TDG (thymine-DNA glyscosylase), and
Agus Darwanto +63 more
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Pyrimidine-2-carboxamide [PDF]
Acta Crystallographica Section E Structure Reports Online, 2007 In the crystal strucuture of the title compound, C(5)H(5)N(3)O, which was obtained upon recrystallization of 2-cyano-pyrimidine from aqueous sodium hydroxide, the amide group is twisted with respect to the aromatic ring by 24.9 (1)°. π-π stacking is observed between partially overlapped rings at a face-to-face separation of 3.439 (6) Å.
Jing-Jing Nie, Qian Yang, Bing-Yu Zhang
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Pyrimidine biosynthesis is not an essential function for trypanosoma brucei bloodstream forms [PDF]
, 2013 <p>Background: African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.</p> <p>Methodology/Principal ...
A Hofer +51 more
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