Results 241 to 250 of about 172,292 (284)
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A polarographic study of pyrimidines
Archives of Biochemistry and Biophysics, 1952Summary Of 26 pyrimidines investigated, 10 have been found to reduce at the dropping mercury electrode. The number of electrons taking part in the reduction has been calculated for a number of cases. It is suggested that the reducible group in these compounds involves the Download : Download full-size image system. On the basis of an
Bertram A. Lowy, Liebe F. Cavalieri
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Greener [3+3] tandem annulation–oxidation approach towards the synthesis of substituted pyrimidines
, 2015An economical and green synthesis of partly and fully substituted pyrimidines is described using α,β-unsaturated ketones and benzamidine hydrochloride using greener and recyclable choline hydroxide (ChOH) as both a catalyst and a reaction medium.
Kamlesh S. Vadagaonkar +3 more
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Anti-cancer pyrimidines in diverse scaffolds: a review of patent literature.
Recent Patents on Anti-Cancer Drug Discovery, 2014Pyrimidine ring is the building unit of DNA and RNA and thus pyrimidine based chemical architectures exhibit diverse pharmacological activities. Among the reported medicinal attributes of pyrimidines, anticancer activity is the most extensively reported.
R. Kaur +6 more
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Journal of Organic Chemistry, 2014
The synthesis, resolution, structure, and racemization of inherently chiral 1,3-alternate azacalix[4]pyrimidine macrocycles are reported. Site-selective halogenations of monohalo-substituted azacalix[4]pyrimidines with NBS, NCS, and NFSI produced a ...
Jiang Li +4 more
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The synthesis, resolution, structure, and racemization of inherently chiral 1,3-alternate azacalix[4]pyrimidine macrocycles are reported. Site-selective halogenations of monohalo-substituted azacalix[4]pyrimidines with NBS, NCS, and NFSI produced a ...
Jiang Li +4 more
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The Effect of Different Purines and Pyrimidines on Human Pyrimidine Biosynthesis
1977Hereditary orotaciduria is caused by the patient’s inability to convert orotic acid to uridine monophosphate, due to an absence of the activity of orotidine phosphate decarboxylase in all cases and orotate phosphoribosyl-transferase in all cases but one. All or nearly all of the orotic acid formed by biosynthesis must be excreted or degraded. Therefore,
A. Rauch-Janssen +2 more
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1975
Publisher Summary This chapter covers the literature for the period from the latter part of 1994 to the early part of 1998. This period has seen the continued use of pyrimidine drugs—such as AZT and ddC in the treatment of viral diseases and the development of new analogues of these compounds, for example, 3TC (3’-thiocytosine).
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Publisher Summary This chapter covers the literature for the period from the latter part of 1994 to the early part of 1998. This period has seen the continued use of pyrimidine drugs—such as AZT and ddC in the treatment of viral diseases and the development of new analogues of these compounds, for example, 3TC (3’-thiocytosine).
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Biological activities of [1,2,4]triazolo[1,5-a]pyrimidines and analogs
Medicinal Chemistry Research, 2020S. Pinheiro +5 more
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Pyrimidines. VIII. Pyrimidine Derivatives of Thioguanine
Journal of Medicinal and Pharmaceutical Chemistry, 1962Henry C. Koppel +3 more
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New England Journal of Medicine, 1973
PURINE metabolism in man has been studied extensively since the time of Garrod. Its end product is a readily measurable purine, uric acid, which reflects overall purine metabolism and, in uricotelic organisms, the major pathway of nitrogen excretion as well.
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PURINE metabolism in man has been studied extensively since the time of Garrod. Its end product is a readily measurable purine, uric acid, which reflects overall purine metabolism and, in uricotelic organisms, the major pathway of nitrogen excretion as well.
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