Results 81 to 90 of about 104,207 (331)
Catalytic 1,2‐Migratory Insertion in a Bismuth Redox Platform: Reductive Arylation of Aldehydes
Angewandte Chemie, EarlyView.We report a multicomponent reaction involving an aryl halide, an aldehyde, and a silane derivative, facilitated by low‐valent bismuth redox catalysis under mild conditions. The protocol represents an unprecedented example of four elementary organometallic steps at a Bi center within the catalytic cycle.
Xiangrong Liu +4 more
wiley +2 more sources
SynOpen, 2017 The Suzuki–Miyaura coupling reaction of 4-pyrimidyl tosylates was investigated with aryl, heteroaryl and alkyl boronic acids. The reaction provided 4-substituted pyrimidines in good-to-excellent yields after one-hour microwave irradiation in water at 100
José Rodríguez-Aguilar +4 more
doaj +1 more source
Revisiting the structure and chemistry of 3(5)-Substituted Pyrazoles [PDF]
, 2019 Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry, often used as starting materials for the preparation of more complex heterocyclic systems with relevance in the pharmaceutical field.
Alam +34 more
core +2 more sources
Advanced Science, EarlyView.Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal +15 more
wiley +1 more source
Modular synthesis of the pyrimidine core of the manzacidins by divergent Tsuji–Trost coupling
Beilstein Journal of Organic Chemistry, 2016 The design, development and application of an efficient procedure for the concise synthesis of the 1,3-syn- and anti-tetrahydropyrimidine cores of manzacidins are reported.
Sebastian Bretzke +5 more
doaj +1 more source
The accumulation of orotic acid by a pyrimidineless mutant of Neurospora [PDF]
, 1948 The discovery of orotic acid (1,2-carboxyuracil) in cow's milk by Biscaro and Belloni (1), followed by its identification and synthesis (2-4), led to a number of speculations as to its biological origin and significance (,3,5,6).
Houlahan, Mary B. +2 more
core
Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT
Advanced Science, EarlyView.Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai +13 more
wiley +1 more source
Smiles‐Truce Cascades Enable Heteroaryl Cyclopropane and Sultine Synthesis
Angewandte Chemie, EarlyView.A triple C─C cascade approach to the synthesis of heteroaryl cyclopropanes is described. The reaction is metal‐free, uses simple starting materials, and presents a new retrosynthetic approach for heteroaryl cyclopropane synthesis. A change of substituent creates a new route to sultines, under‐explored motifs in medicinal chemistry. Abstract We describe
Thomas Sephton +2 more
wiley +2 more sources
MoleculesCancer is a leading cause of death globally, claiming millions of lives each year. Despite the availability of numerous anticancer drugs, the need for new treatment options remains essential. Many current therapies come with significant toxicity, lead to
Simona Iacob (Ciobotaru) +9 more
doaj +1 more source
Metformin use in pregnancy: promises and uncertainties [PDF]
, 2017 Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically, and the evidence base has been confined to observational studies.
Lindsay, Robert S., Loeken, Mary R.
core +1 more source