Results 201 to 210 of about 4,994 (242)

An 8-year-old girl with secondary histiocytic sarcoma with BRAF^V600 mutation following T-cell acute lymphoblastic leukemia demonstrating stable disease for 3 years on dabrafenib and trametinib - a case report and literature review. [PDF]

BMC Pediatr
Tan SL, Ho BLS, Yew TT, Yunus D.
europepmc   +1 more source

Pharmacological Interpretation of the Efficacy of Ensifentrine in Chronic Obstructive Pulmonary Disease: Insights from ENHANCE Trials. [PDF]

Am J Respir Crit Care Med
Calzetta L, Cazzola M, Rogliani P.
europepmc   +1 more source

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New Pyrimidinone and Fused Pyrimidinone Derivatives as Potential Anticancer Chemotherapeutics

Archiv der Pharmazie, 2012
AbstractA series of novel substituted pyrimidinones and fused pyrimidinones (compounds 3–18) were synthesized starting with oxiranylmethanone 2. The in vitro cytotoxicity against a human breast adenocarcinoma (MCF‐7) cell line was investigated and most of the tested compounds showed potent cytotoxic activity against the MCF‐7 cell line comparable to ...
Aymn E, Rashad, Ahmed H, Shamroukh, Nabil M, Yousif, Mowafia A, Salama, Hatem S, Ali, Mamdouh M, Ali, Abeer E, Mahmoud, Mahmoud, El-Shahat   +7 more
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Ethynyltriisopropoxytitanium reactions with pyrimidinones

Journal of Organometallic Chemistry, 1988
Abstract Ethynyltriisopropoxytitanium has been generated in situ from ethynyllithium and chlorotriisopropoxytitanium at −80°C. It forms 1 1 adducts with pyrimidin-2(1 H )-ones with exclusive carbon-carbon bond formation at C(6). The products after quenching ethynylmagnesium bromide with chlorotriisopropoxytitanium at −10°C are 1 1 the ...
Frode Rise, David Grace, Kjell Undheim
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Synthesis of fluorinated pyrimidinones

Journal of Fluorine Chemistry, 2013
Abstract A method for the construction of fluorinated pyrimidinones based on the reaction of cyanodifluoromethyl-substituted amines with isocyanates is described. The use of ortho-iodophenylisocyanate in this reaction followed by copper catalyzed intramolecular amination affords fluorinated fused heterocycles – 4-fluoropyrimido[1,6-a]benzimidazol-1 ...
Mikhail D. Kosobokov, Marina I. Struchkova, Dmitry E. Arkhipov, Alexander A. Korlyukov, Alexander D. Dilman   +4 more
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Pyrimidinones as biodynamic agents

1987
In view of the diverse types of biological activities associated with pyrimidinones and molecules having pyrimidinone as a component substructure, the pyrimidinone moiety may be considered as an important pharmacophore for incorporation in the design of molecules of biological interest.
A K, Saxena, S, Sinha
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ChemInform Abstract: New Pyrimidinone and Fused Pyrimidinone Derivatives as Potential Anticancer Chemotherapeutics.

ChemInform, 2013
AbstractA series of new pyrimidinone derivatives is synthesized starting from oxiranyl aryl ketone (I).
Aymn E. Rashad, Ahmed H. Shamroukh, Nabil M. Yousif, Mowafia A. Salama, Hatem S. Ali, Mamdouh M. Ali, Abeer E. Mahmoud, Mahmoud El‐Shahat   +7 more
openaire   +1 more source

Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents

Journal of Medicinal Chemistry, 1985
Interferon induction and antiviral activity was discovered with 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone. An analogue study incorporating a series of 2-amino-5-substituted-6-arylpyrimidinones revealed that the most potent interferon inducers were mono- and difluorophenyl analogues.
H I, Skulnick, S D, Weed, E E, Eidson, H E, Renis, W, Wierenga, D A, Stringfellow   +5 more
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Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribosides

Journal of Medicinal Chemistry, 1985
1-(2-Deoxy-beta-D-ribofuranosyl)-5-bromo-2-pyrimidinone (BrPdR) and 1-(2-deoxy-beta-D-ribofuranosyl)-5-iodo-2-pyrimidinone (IPdR) have been synthesized by condensation of the appropriate silylated bases 2a and 2b, respectively, with 3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-alpha-D-ribofuranosyl chloride (8) in 1,2-dichloroethane, in the presence of SnCl4 ...
S M, Efange, E M, Alessi, H C, Shih, Y C, Cheng, T J, Bardos   +4 more
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Fluorescent 2‐Pyrimidinone Nucleoside in Parallel‐Stranded DNA

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Kaluzhny, D., Mikhailov, S., Efimtseva, E., Borisova, O., Florentiev, V., Shchyolkina, A., Jovin, T.   +6 more
openaire   +3 more sources