Results 201 to 210 of about 7,405 (269)

Synthesis of fluorinated pyrimidinones

Journal of Fluorine Chemistry, 2013
AbstractFluorinated pyrimidinones are constructed in two steps from cyanodifluoromethyl‐substituted amines and isocyanates.
Alexander A. Korlyukov, Marina I. Struchkova, Alexander D. Dilman, Mikhail D. Kosobokov, Dmitry E. Arkhipov   +4 more
openaire   +3 more sources

Syntheses of trifluoromethylated pyridinones and pyrimidinones

The Journal of Organic Chemistry, 1990
Les syntheses s'effectuent via la reaction d'orthoformiates avec des enaminonitriles ou avec des ...
Len F. Lee, Y. Larry Sing
openaire   +2 more sources

Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.

Journal of Medicinal Chemistry, 2019
Phosphodiesterase type 5 (PDE5) inhibitors are first-line therapy for pulmonary arterial hypertension (PAH) and erectile dysfunction. As a continuing work to improve the terminal half-lives and oral bioavailabilities of our previously reported 4(3 H ...
Zhen Wang, Xiangrui Jiang, Xianglei Zhang, Guanghui Tian, Rulei Yang, Jianzhong Wu, Xiaoli Zou, Zheng Liu, Xiaojun Yang, Chunhui Wu, Jing Shi, Jianfeng Li, J. Suo, Yu Wang, Rongxia Zhang, Zhijian Xu, Xu-Bin Gong, Yang He, Weiliang Zhu, H. Aisa, Hualiang Jiang, Yechun Xu, Jingshan Shen   +22 more
semanticscholar   +1 more source

ChemInform Abstract: Photochemistry of 4‐Pyrimidinones. Part 7. Reaction of Dewar 4‐Pyrimidinone with Methylamine.

Chemischer Informationsdienst, 1982
AbstractDie Photolyse der Pyrimidinone (I) in flüssigem Methylamin (II) führt zu den offenkettigen Produkten (III), die bei der Chromatographie an Aluminiumoxid zu den Pyrimidinonen (IV) cyclisieren.
Takao Yamazaki, Y. Hirai, H. Kanmei, S. Hirokami   +3 more
openaire   +2 more sources

Pyrimidinones as biodynamic agents

1987
In view of the diverse types of biological activities associated with pyrimidinones and molecules having pyrimidinone as a component substructure, the pyrimidinone moiety may be considered as an important pharmacophore for incorporation in the design of molecules of biological interest.
Shradha Sinha, Anil K. Saxena
openaire   +3 more sources

Phenylation of pyrimidinones using diphenyliodonium salts

Journal of the Chemical Society, Perkin Transactions 1, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Stig Andre Jacobsen, Tore Benneche, Synne Roedbotten   +2 more
openaire   +3 more sources

Formation and reactions of Dewar 4-pyrimidinones in the photochemistry of 4-pyrimidinones at low temperature. 2

The Journal of Organic Chemistry, 1983
Par photolyse de pyrimidones-4 en solution liquide NH 3 -ether a −40°C ou dans CH 3 OH de −10° a −40°C formation de lactames bicycliques de type Dewar et des autres produits formes ...
Shun-ichi Hirokami, Kazuko Kato, Tamiko Takahashi, Masanori Nagata, Takao Yamazaki   +4 more
openaire   +2 more sources

Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribosides

Journal of Medicinal Chemistry, 1985
AbstractAusgehend von den silylierten Basen (I) erhält man die Verbindungen (V), deren Antiherpes‐Aktivität (HSV‐l, HSV‐2) untersucht.
H. C. Shih, E. M. Alessi, Thomas J. Bardos, Yung-Chi Cheng, Simon M. N. Efange   +4 more
openaire   +4 more sources

Structural Elucidation and Antimicrobial Evaluation of Novel [1,2,4]Triazolo[4,3-a]pyrimidines and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidinones

, 2018
1,3-Di(thiophen-2-yl)prop-2-en-1-one (1) was utilized in the synthesis of 4,6-di(thiophen-2-yl)-3,4-dihydropyrimidine-2(1H)-thione (2) and 5,7-di(thiophen-2-yl)-2-thioxo-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one (4). The latter thiones were used in the
Sobhi M. Gomha, A. M. Mohamed, Yasser H. Zaki, Yasser H. Zaki, M. Ewies, S. Elroby, S. Elroby   +6 more
semanticscholar   +1 more source

Introduction of Poly(4-Vinylpyridine) as an Efficient Promotor for the Synthesis of Pyrano[2,3-d]Pyrimidinones and Pyrido[2,3-d]Pyrimidines

Polycyclic aromatic compounds (Print), 2018
This article describes an efficient method for the synthesis of pyrano[2,3-d]pyrimidinones and pyrido[2,3-d]pyrimidines via promotion of the condensation of aromatic aldehydes, malononitrile and barbituric acid and/or 6-amino-1,3-dimethyluracil in the ...
Leyla Nazemi Nasirmahale, F. Shirini, O. Goli-Jolodar, H. Tajik   +3 more
semanticscholar   +1 more source