Results 21 to 30 of about 4,994 (242)
Zanco Journal of Pure and Applied Sciences, 2023 The Biginelli Reaction is a one-pot acid catalyzed cyclocondensation of -keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalized 3,4-dihydro-2(H)-pyrimidinones (DHPMs).
Rostam R. Braiem
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Syntheses and Studies of Metaphase-Arresting Pyrimidinones. [PDF]
Acta Chemica Scandinavica, 1991 Methods are described for the syntheses of chloromethyl hydroxyalkylphenyl and benzyl ethers, and for the synthesis of bromomethyl phenyl ketone analogs. The hydroxy groups were protected as acetates. The halogenomethyl derivatives have been used for N-alkylation of 5-chloro-2(1H)-pyrimidinone.
Tore Benneche +7 more
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Molecules, 2021 In this article, we showed the synthesis of new polycyclic aromatic compounds, such as thienotriazolopyrimidinones, N-(thienotriazolopyrimidine) acetamide, 2-mercapto-thienotriazolo-pyrimidinones, 2-(((thieno-triazolopyrimidine) methyl) thio) thieno ...
Ameen Ali Abu-Hashem +2 more
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Memorias do Instituto Oswaldo Cruz, 2018 BACKGROUND Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs.
Kamilla Rodrigues Rogerio +9 more
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Solid-Phase Synthesis of Oligo-2-Pyrimidinone-2'-Deoxyribonucleotides and Oligo-2-Pyrimidinone-2'-Deoxyriboside Methylphosphonates [PDF]
Nucleic Acids Research, 1996 A synthetic method was developed for the synthesis of oligodeoxyribonucleotides and oligodeoxyribonucleoside methylphosphonates comprised exclusively of the fluorescent 2-pyrimidinone base for the first time. The method utilized the solid-phase 2-cyanoethylphosphoramidite and methylphosphonamidite chemistry for internucleotide couplings and a ...
Y, Zhou, P O, Ts'o
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Molecules, 2013 In this study, a series of conformationally restricted thieno[3,2-d]pyrimidinones, thieno[3,2-d]pyrimidines and quinazolinones was designed and synthesized with the goal of improving the biological activity as 17b-hydroxysteroid dehydrogenase type 2 ...
Rolf W. Hartmann +2 more
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Repair, abort, ignore? Strategies for dealing with UV damage [PDF]
, 2011 DNA repair is a prominent member of the nuclear transactions triad (replication, transcription, and repair). Sophisticated mechanisms govern the cellular process of decision-making (to repair or not to repair, to proceed with cell cycle or not and ...
Khalil, Hilal S. +2 more
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Molecules, 2011 all-endo-3-amino-5-hydroxybicyclo[2.2.2]octane-2-carboxylic acid (13) and all-endo-5-amino-6-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol (10) were prepared via dihydro-1,3-oxazine or g-lactone intermediates by the stereoselective functionalization of an N ...
Márta Palkó +2 more
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Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation
Beilstein Journal of Organic Chemistry, 2018 A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established.
Mark Kelada +4 more
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CHIMIA, 2003 In this short review, new quinazolinones and thieno-pyrimidinones with outstanding powdery mildew activity are introduced. The most important inventions of two major players in this field, DuPont and Syngenta, are presented and interesting ...
Harald Walter, Ronald Zeun
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