The PRY/SPRY domain of pyrin/TRIM20 interacts with β2-microglobulin to promote inflammasome formation [PDF]
Scientific Reports, 2021 Pyrin/TRIM20 is expressed in the neutrophils and monocytes/macrophages and regulates caspase-1 activation and interleukin-1β maturation. Although the mutations in the PRY/SPRY domain of pyrin cause familial Mediterranean fever (FMF), the mechanism of how
Sei Samukawa +3 more
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A semi‐automated ASC speck assay to evaluate pyrin inflammasome activation [PDF]
Clinical & Translational ImmunologyObjective To develop a rapid functional assay to validate variants of uncertain significance (VUS) in the MEFV gene. Methods Overactivity of the pyrin inflammasome pathway and ASC speck oligomerisation in response to stimulation with low concentrations ...
Pei Dai +21 more
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CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation [PDF]
Nature CommunicationsThe circular RNA (circRNA) family is a group of endogenous non-coding RNAs (ncRNAs) that have critical functions in multiple physiological and pathological processes, including inflammation, cancer, and cardiovascular diseases.
Nana Xu +10 more
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Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis
Nature Immunology, 2020 Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by homozygous or compound heterozygous gain-of-function mutations in MEFV, which encodes pyrin, an inflammasome protein. Heterozygous carrier frequencies for multiple MEFV mutations
Elaine F Remmers +2 more
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The Pyrin Inflammasome in Health and Disease
Frontiers in Immunology, 2019 The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar to the “guard” mechanism in plants. Rho GTPases act as molecular switches to
Oskar Schnappauf +2 more
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Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients [PDF]
EMBO Molecular Medicine, 2019 Familial Mediterranean fever (FMF) is the most frequent hereditary systemic autoinflammatory syndrome. FMF is usually caused by biallelic mutations in the MEFV gene, encoding Pyrin.
Flora Magnotti +17 more
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Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis [PDF]
Cellular and Molecular Immunology, 2023 , Sangjoon Lee
exaly +3 more sources
Frontiers in Immunology, 2023 BackgroundNeutrophil extracellular traps (NETs) can cause acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) by inducing macrophage pyroptosis.
Chenchen Liu +6 more
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Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis [PDF]
Frontiers in Pharmacology, 2020 Berberine (BBR), an isoquinoline alkaloid originating from herbal plants, has been deemed beneficial for non-alcoholic fatty liver disease. Increasing evidence has demonstrated that Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome ...
Weijian Mai +13 more
semanticscholar +2 more sources
Frontiers in Immunology, 2020 Recent research has led to novel findings in inflammasome biology and genetics that altered the diagnosis and management of patients with autoinflammatory syndromes caused by NLRP3-, Pyrin-, NLRP1-, and NLRC4-inflammasomes and spurred the development of ...
Sara Alehashemi +1 more
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