Results 21 to 30 of about 88,038 (326)
Caspase-14-like Proteases: An Epidermal Caspase and Its Evolutionarily Ancient Relatives [PDF]
BiomoleculesCaspases are a family of cysteine-dependent aspartate-directed proteases implicated in programmed cell death. Humans have eleven proteolytically active caspases, namely caspase-1 through -10 and caspase-14.
Leopold Eckhart +3 more
doaj +2 more sources
NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain
Journal of Experimental Medicine, 2017 NLRP3 is a cytosolic pattern recognition receptor that senses microbes and endogenous danger signals. Upon activation, NLRP3 forms an inflammasome with the adapter ASC, resulting in caspase-1 activation, release of proinflammatory cytokines and cell ...
A. Stutz +9 more
semanticscholar +2 more sources
Hepatology, 2019 The NLR family pyrin domain‐containing 3 (NLRP3) inflammasome plays an important role in liver fibrosis (LF) development. However, the mechanisms involved in NLRP3‐induced fibrosis are unclear.
Robert F Schwabe +2 more
exaly +2 more sources
Hepatology, 2019 The Hippo pathway, an evolutionarily conserved protein kinase cascade, tightly regulates cell growth and survival. Activation of yes‐associated protein (YAP), a downstream effector of the Hippo pathway, has been shown to modulate tissue inflammation ...
Changyong Li +2 more
exaly +2 more sources
Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling [PDF]
EMBO Molecular MedicineGeranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, serves as the substrate for protein geranylgeranylation, a process catalyzed by geranylgeranyl transferase I (GGTase-I).
Murali K Akula +12 more
doaj +2 more sources
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. [PDF]
PLoS Pathogens, 2016 Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling.
Dmitry Ratner +12 more
doaj +6 more sources
The pyrin inflammasome and the Yersinia effector interaction
Immunological Reviews, 2020 Pyrin is a cytosolic pattern‐recognition receptor that normally functions as a guard to trigger capase‐1 inflammasome assembly in response to bacterial toxins and effectors that inactivate RhoA.
H. Malik, J. Bliska
semanticscholar +4 more sources
The PYRIN Domain in Signal Transduction [PDF]
Current Protein & Peptide Science, 2007 The Death Domain Fold superfamily of evolutionarily conserved protein-protein interaction domains consists of 4 subfamilies: the death domain, the death effector domain, the caspase recruitment domain, and the PYRIN domain. Interaction of Death Domain Fold containing proteins modulates the activity of several downstream effectors, such as caspases and ...
Christian Stehlik
openalex +4 more sources
PSTPIP1 and pyrin, two key regulators of macrophage differentiation
European Journal of Cell BiologyBackground: Monocytes develop from hematopoietic stem cells; migrate into the tissue, where they undergo a stimulation-dependent and tissue specific differentiation into macrophages imprinting specific inflammatory functions.
Philipp Berger +15 more
doaj +2 more sources
Bile acid analogues are activators of pyrin inflammasome [PDF]
Journal of Biological Chemistry, 2019 Bile acids are critical metabolites in the gastrointestinal tract and contribute to maintaining intestinal immune homeostasis through cross-talk with the gut microbiota.
I. Alimov +16 more
semanticscholar +3 more sources