Results 31 to 40 of about 88,038 (326)
POPing the fire into the pyrin? [PDF]
Biochemical Journal, 2003 Initiation of an inflammatory response requires the co-ordinated participation of proteins within a scaffold in the cytosol of responding cells. The scaffold proteins contain members of a newly discovered family of pyrin-domain adaptor proteins that regulate complex assembly for initiation of nuclear factor κB and interleukin-1β signalling.
Sanjeev Mariathasan, Domagoj Vucic
openalex +4 more sources
Design principles for inflammasome inhibition by pyrin-only-proteins
eLifeInflammasomes are filamentous signaling platforms essential for host defense against various intracellular calamities such as pathogen invasion and genotoxic stresses.
Shuai Wu +9 more
doaj +2 more sources
AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense
Nature, 2021 Inflammasomes are important sentinels of innate immune defence, sensing pathogens and inducing cell death in infected cells1. There are several inflammasome sensors that each detect and respond to a specific pathogen- or damage-associated molecular ...
Sangjoon Lee +5 more
semanticscholar +1 more source
Actin Remodeling Defects Leading to Autoinflammation and Immune Dysregulation
Frontiers in Immunology, 2021 A growing number of monogenic immune-mediated diseases have been related to genes involved in pathways of actin cytoskeleton remodeling. Increasing evidences associate cytoskeleton defects to autoinflammatory diseases and primary immunodeficiencies.
Riccardo Papa +3 more
doaj +1 more source
Frontiers in Medicine, 2022 ObjectiveThe frequency of vasculitis may be increased in patients with Familial Mediterranean Fever (FMF), according to several studies. Our aim was to assess the characteristics of French adult patients with both diseases.MethodsPatients with vasculitis
Salam Abbara +17 more
doaj +1 more source
Pharmacological Reviews, 2021 Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome drives release of the proinflammatory cytokines interleukin (IL)-1β and IL-18 and induces pyroptosis (lytic cell death).
Sarah E. Corcoran +2 more
semanticscholar +1 more source
Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling. [PDF]
, 2012 BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse ...
Fang, Jianwen +5 more
core +13 more sources
The Death-domain Fold of the ASC PYRIN Domain, Presenting a Basis for PYRIN/PYRIN Recognition [PDF]
Journal of Molecular Biology, 2003 The PYRIN domain is a conserved sequence motif identified in more than 20 human proteins with putative functions in apoptotic and inflammatory signalling pathways. The three-dimensional structure of the PYRIN domain from human ASC was determined by NMR spectroscopy. The structure determination reveals close structural similarity to death domains, death
Liepinsh, Edvards +5 more
openaire +3 more sources