Results 41 to 50 of about 88,038 (326)
Frontiers in Immunology, 2022 Inflammasomes are multi-protein platforms that are assembled in response to microbial and danger signals to activate proinflammatory caspase-1 for production of active form of IL-1β and induction of pyroptotic cell death. Where and how an inflammasome is
Dandan Wu +5 more
doaj +1 more source
Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains Gives Insights into Pyrin Inflammasome Assembly [PDF]
Journal of Biological Chemistry, 2014 Inflammasomes are macromolecular complexes that mediate inflammatory and cell death responses to pathogens and cellular stress signals. Dysregulated inflammasome activation is associated with autoinflammatory syndromes and several common diseases. During inflammasome assembly, oligomerized cytosolic pattern recognition receptors recruit procaspase-1 ...
Vajjhala, Parimala R. +6 more
openaire +3 more sources
In Silico Study of Pyrin and 14-3-3 Protein Modulation During FMF and PAAND. [PDF]
ACS OmegaParonyan A +5 more
europepmc +2 more sources
The Journal of Experimental Medicine, 2004 Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several ...
Christian Stehlik, John C. Reed
openaire +1 more source
TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy [PDF]
Journal of Clinical Investigation, 2018 Pyrin is an inflammasome sensor that promotes caspase-1-mediated pyroptotic cell death and maturation of proinflammatory cytokines IL-1β and IL-18. Familial Mediterranean fever (FMF), an autoinflammatory disorder, is associated with mutations in the gene encoding pyrin (MEFV).
Deepika Sharma +4 more
openaire +2 more sources
Chest pain in children with familial Mediterranean fever
The Turkish Journal of Pediatrics, 2023 Background. Familial Mediterranean fever (FMF) is the most common and autosomal recessive inherited autoinflammatory disease. The most common signs and symptoms are fever, abdominal pain, chest pain, and arthritis.
Emine Nur Sunar-Yayla +3 more
doaj +1 more source
International Journal of Molecular Medicine, 2021 Epilepsy comorbidities and anti-epileptic drugs (AEDs) are currently the main limitations of epilepsy treatment. Semaglutide is a glucagon like peptide-1 analogue that has entered the market as a new once-weekly drug for type II diabetes.
Lei Wang +10 more
semanticscholar +1 more source
Current Issues in Molecular Biology, 2023 Epigenetic modifications play a pivotal role in autoimmune/inflammatory disorders and could establish a bridge between personalized medicine and disease epidemiological contexts.
May E. Zekry +5 more
doaj +1 more source
Frontiers in Microbiology, 2022 Herpes simplex virus type 1 (HSV-1) is a highly prevalent virus in humans and causes severe forms of inflammation, such as herpes simplex encephalitis (HSE).
Xiao Hu +11 more
semanticscholar +1 more source
Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation
Journal of Experimental Medicine, 2022 Using induced pluripotent stem cells carrying CDC42R186C, trapping of CDC42 C-terminal variants within the Golgi apparatus is shown to trigger autoinflammation by promoting pyrin inflammasome assembly through a mechanism independent of their GTPase ...
M. Nishitani-Isa +22 more
semanticscholar +1 more source