Results 71 to 80 of about 9,191 (227)
The Basicity of 2,6-Dimethyl-4-pyrone
, 1985 Conductimetric and spectrophotometric measurements of the Ka of protonated 2,6-dimethyl-4-pyrone have been made. The conductimetrically determined value of pKa = 0.17 0.03 was 0.2 pK units higher than the value of pKa = -0.02 0.05 found ...
JR Farrell, P Mctigue
core +1 more source
3-(9H-Carbazol-9-yl)-2H-chromen-2-one
Acta Crystallographica Section E, 2011 The title compound, C21H13NO2, was prepared as an example of a new synthesis of carbazoles from a cyclic dibenzo-iodolium salt via a twofold Pd-catalysed arylation of a primary amine.
Julien Letessier +2 more
doaj +1 more source
MoleculesTwo α-pyrone analogs were isolated from the endophytic fungus Diaporthe sp. CB10100, which is derived from the medicinal plant Sinomenium acutum. These analogs included a new compound, diaporpyrone F (3), and a known compound, diaporpyrone D (4).
Zhong Wang +9 more
doaj +1 more source
Breaking Down Barriers: CorA Effectively Targets Staphylococcal Biofilms in Vitro and in Vivo
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Corallopyronin A (CorA), a natural alpha‐pyrone antibiotic, penetrates Staphylococcus aureus biofilms and inhibits RNA polymerase. This work demonstrates CorA's superior efficacy compared to rifampicin and dalbavancin in reducing viable loads in biofilms both in vitro and in vivo. Graphic created in https://BioRender.com.
Stefania De Benedetti +21 more
wiley +1 more source
Potent, Selective Pyrone-Based Inhibitors of Stromelysin-1
, 2016 In an effort to develop alternatives to hydroxamate-based matrix metalloproteinase inhibitors (MPIs), we have utilized the drug discovery program LUDI enhanced with the structural coordinates of a bioinorganic model complex.
John Mongan (2667169) +4 more
core +1 more source
, 2016 A base-promoted domino reaction of 2-acyl-1-chlorocyclopropaneformic esters with amines is described. In the presence of inorganic bases like Cs2CO3 or Mg(OEt)2, the reaction proceeded smoothly in acetonitrile to afford 2-pyrone derivatives in modest to
Yuequan Zhu (1695862) +1 more
core +2 more sources
Biomolecules, 2020 Glutamate toxicity has been implicated in neuronal cell death in both acute CNS injury and in chronic diseases. In our search for neuroprotective agents obtained from natural sources that inhibit glutamate toxicity, an endophytic fungus, Fusarium solani ...
Hyun Gyu Choi +6 more
doaj +1 more source
MedComm, Volume 7, Issue 4, April 2026.This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva +3 more
wiley +1 more source