Results 81 to 90 of about 4,197 (216)
DEVELOPMENT OF NEW ACCESS ROUTES TO PYRAZOLO[1,5-a]PYRIMIDINE USING 4-HYDROXY-6-METHYLPYRAN-2-ONE
Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2011 In this work, we propose a new and fast strategy giving the pyrazolo[1,5-a]pyrimidines substituted at positions 5 and 7 via condensation of 3-amino-5-arylpyrazoles with 2-hydroxy-6-methylpyran-2-one in both conventional heating and microwave irradiation.
El Mokhtar Essassi +3 more
doaj
Two New Pyrone Derivatives from the Plant Endophytic Fungus sp
Natural Product Communications, 2014 Two new α-pyrones, Exserolide G–H (1–2) , together with one known metabolite, stemphypyrone (3) , were isolated from the solid-substrate fermentation cultures of the plant endophytic fungus Exserohilum sp.
Ruxin Li +3 more
doaj +1 more source
Breaking Down Barriers: CorA Effectively Targets Staphylococcal Biofilms in Vitro and in Vivo
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Corallopyronin A (CorA), a natural alpha‐pyrone antibiotic, penetrates Staphylococcus aureus biofilms and inhibits RNA polymerase. This work demonstrates CorA's superior efficacy compared to rifampicin and dalbavancin in reducing viable loads in biofilms both in vitro and in vivo. Graphic created in https://BioRender.com.
Stefania De Benedetti +21 more
wiley +1 more source
BMC Genomics, 2018 Background Black Aspergilli represent one of the most important fungal resources of primary and secondary metabolites for biotechnological industry.
Elodie Choque +4 more
doaj +1 more source
MedComm, Volume 7, Issue 4, April 2026.This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva +3 more
wiley +1 more source
A flexible route to bioactive 6-alkyl-α-pyrones [PDF]
, 2017 Both 6-chloro-α-pyrones and 3-chlorobenzopyran-1-ones react with malonates followed by a double decarboalkoxylation to give the corresponding alkyl and alkenyl products.This is a manuscript of an article published as Qu, Yang, and George A. Kraus.
Kraus, George, Qu, Yang
core +1 more source
Syntheses of Conjugated Pyrones for the Enzymatic Assay of Lovastatin Nonaketide Synthase, an Iterative Polyketide Synthase [PDF]
, 2016 Lovastatin nonaketide synthase (LovB, LNKS) is an iterative type I polyketide synthase (PKS) from Aspergillus terreus that produces dihydromonacolin L (2), the biosynthetic precursor of lovastatin (1), from acetyl CoA, malonyl CoA, and S ...
John C. Vederas (174316) +2 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2014 Two mild and efficient strategies have been developed for the O-functionalisation of 4-hydroxy-6-alkyl-2-pyrones, by using them as nucleophilic partners in oxa-Michael additions and the Mitsunobu reaction.
Michael J. Burns +3 more
doaj +1 more source