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Pyroptosis: mechanisms and diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family.
Pian Yu +5 more
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SGLT2 inhibition attenuates diabetic tubulopathy by suppressing SGK1-mediated pyroptosis [PDF]
Frontiers in EndocrinologyBackgroundDiabetic tubulopathy is increasingly recognized as a pivotal contributor to diabetic kidney disease (DKD) progression. Excessive pyroptosis of renal tubular epithelial cells exacerbates inflammation and tissue injury.
Xu Shi +20 more
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Emerging Mechanisms and Targeted Therapy of Pyroptosis in Central Nervous System Trauma
Frontiers in Cell and Developmental Biology, 2022 Cell death can occur in different modes, ferroptosis, pyroptosis, apoptosis, and necroptosis. Recent studies have shown that pyroptosis can be effectively regulated and that like necroptosis, pyroptosis has been regarded as a type of programmed cell ...
Biao Yang +4 more
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Noncoding RNAs in pyroptosis and cancer progression: Effect, mechanism, and clinical application
Frontiers in Immunology, 2022 Cell death is generally classified into two categories: regulated cell death (RCD) and accidental cell death (ACD). In particular, RCD is a kind of genetically controlled process, including programmed apoptotic death and programmed necrotic death ...
Menghui Zhang +4 more
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Scientific Reports, 2023 Pyroptosis is a type of programmed cell death and plays a dual role in distinct cancers. It is elusive to evaluate the activation level of pyroptosis and to appraise the involvement of pyroptosis in the occurrence and development of diverse tumors ...
Jin-Zhou Xu +11 more
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Scientific Reports, 2022 Understanding the association of pyroptosis with tumor progression, prognosis and effect on immunotherapeutic response in breast cancer (BC) is limited. This study analysed forty pyroptosis-related genes to construct the pyroptosis score.
Guo Huang +3 more
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NLRP3 inflammasome-induced pyroptosis in digestive system tumors
Frontiers in Immunology, 2023 Programmed cell death (PCD) refers to cell death in a manner that depends on specific genes encoding signals or activities. PCD includes apoptosis, pyroptosis, autophagy and necrosis (programmed necrosis).
Jiexia Wen +8 more
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Frontiers in Genetics, 2023 The phenotype of pyroptosis has been extensively studied in a variety of tumors, but the relationship between pyroptosis and esophageal squamous cell carcinoma (ESCC) remains unclear. Here, 22 pyroptosis genes were downloaded from the website of Gene Set
Zhan-Fei Zhang, Zhan-Fei Zhang
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Journal of Translational Medicine, 2022 Background Programmed cell death is an active and orderly form of cell death regulated by intracellular genes that plays an important role in the normal occurrence and development of the immune system, and pyroptosis has been found to be involved in ...
Aibin Liu +4 more
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Induction of Pyroptosis: A Promising Strategy for Cancer Treatment
Frontiers in Oncology, 2021 Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied in diverse inflammatory disease models. Membrane perforation and cell swelling induced by cleaved gasdermin family members is the main characteristic of ...
Lei Wang +3 more
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