Results 1 to 10 of about 53,940 (298)

Pyroptosis: mechanisms and diseases

Signal Transduction and Targeted Therapy, 2021
Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family.
Pian Yu, Xu Zhang, Nian Liu, Ling Tang, Cong Peng, Xiang Chen   +5 more
doaj   +2 more sources

Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities. [PDF]

Biomark Res
Remarkable advances have been achieved following discoveries that gasdermins are the executioners of pyroptosis. The pyroptotic process consists a subcellular permeabilization phase and a cell lysis phase, the latter of which is irreversible.
Miao R, Wang X, Zhang J, Kang Q, Liu Q, Luo X, Hou J, Gao B.   +7 more
europepmc   +2 more sources

Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer. [PDF]

J Immunother Cancer
Background Despite advancements in treatment modalities, several patients with colorectal cancer (CRC) remain unresponsive to immune checkpoint inhibitor therapy.
Li L, Zhao L, Zhou D, Yu Y, Zhang P, Zheng J, Lin Z, Yu D, Ren J, Zhang J, Zhou P, Zhang D, Zhang T.   +12 more
europepmc   +2 more sources

Pyroptosis in health and disease: mechanisms, regulation and clinical perspective

Signal Transduction and Targeted Therapy
Pyroptosis is a type of programmed cell death characterized by cell swelling and osmotic lysis, resulting in cytomembrane rupture and release of immunostimulatory components, which play a role in several pathological processes.
Yifan Liu, Renjie Pan, Yuzhen Ouyang, Wangning Gu, Tengfei Xiao, Hongmin Yang, Ling Tang, Hui Wang, Bo Xiang, Pan Chen   +9 more
doaj   +2 more sources

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Nature, 2016
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman   +6 more
openalex   +3 more sources

Emerging Mechanisms and Targeted Therapy of Pyroptosis in Central Nervous System Trauma

Frontiers in Cell and Developmental Biology, 2022
Cell death can occur in different modes, ferroptosis, pyroptosis, apoptosis, and necroptosis. Recent studies have shown that pyroptosis can be effectively regulated and that like necroptosis, pyroptosis has been regarded as a type of programmed cell ...
Biao Yang, Biao Yang, Weijie Zhong, Ying Gu, Yi Li   +4 more
doaj   +1 more source

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Cellular & Molecular Immunology, 2021
Cell death is a fundamental physiological process in all living organisms. Its roles extend from embryonic development, organ maintenance, and aging to the coordination of immune responses and autoimmunity.
D. Bertheloot, E. Latz, B. S. Franklin
semanticscholar   +1 more source

Noncoding RNAs in pyroptosis and cancer progression: Effect, mechanism, and clinical application

Frontiers in Immunology, 2022
Cell death is generally classified into two categories: regulated cell death (RCD) and accidental cell death (ACD). In particular, RCD is a kind of genetically controlled process, including programmed apoptotic death and programmed necrotic death ...
Menghui Zhang, Pengyuan Dang, Yang Liu, Bingbing Qiao, Zhenqiang Sun   +4 more
doaj   +1 more source

Establishment of a novel indicator of pyroptosis regulated gene transcription level and its application in pan-cancer

Scientific Reports, 2023
Pyroptosis is a type of programmed cell death and plays a dual role in distinct cancers. It is elusive to evaluate the activation level of pyroptosis and to appraise the involvement of pyroptosis in the occurrence and development of diverse tumors ...
Jin-Zhou Xu, Qi-Dong Xia, Jian-Xuan Sun, Chen-Qian Liu, Jun-Lin Lu, Meng-Yao Xu, Ye An, Yang Xun, Zheng Liu, Jia Hu, Cong Li, Shao-Gang Wang   +11 more
doaj   +1 more source

NLRP3 monomer Functional Dynamics: from the Effects of Allosteric Binding to Implications for Drug Design [PDF]

International Journal of Biological Macromolecules 246 (2023) 125609, 2023
The protein NLRP3 and its complexes are associated with an array of inflammatory pathologies, among which neurodegenerative, autoimmune, and metabolic diseases. Targeting the NLRP3 inflammasome represents a promising strategy for easing the symptoms of pathologic neuroinflammation.
arxiv   +1 more source