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Pyroptosis: mechanisms and diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family.
Pian Yu +5 more
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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Nature, 2016 Xing Liu +6 more
openalex +3 more sources
Emerging Mechanisms and Targeted Therapy of Pyroptosis in Central Nervous System Trauma
Frontiers in Cell and Developmental Biology, 2022 Cell death can occur in different modes, ferroptosis, pyroptosis, apoptosis, and necroptosis. Recent studies have shown that pyroptosis can be effectively regulated and that like necroptosis, pyroptosis has been regarded as a type of programmed cell ...
Biao Yang +4 more
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Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
Cellular & Molecular Immunology, 2021 Cell death is a fundamental physiological process in all living organisms. Its roles extend from embryonic development, organ maintenance, and aging to the coordination of immune responses and autoimmunity.
D. Bertheloot, E. Latz, B. S. Franklin
semanticscholar +1 more source
Noncoding RNAs in pyroptosis and cancer progression: Effect, mechanism, and clinical application
Frontiers in Immunology, 2022 Cell death is generally classified into two categories: regulated cell death (RCD) and accidental cell death (ACD). In particular, RCD is a kind of genetically controlled process, including programmed apoptotic death and programmed necrotic death ...
Menghui Zhang +4 more
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Scientific Reports, 2023 Pyroptosis is a type of programmed cell death and plays a dual role in distinct cancers. It is elusive to evaluate the activation level of pyroptosis and to appraise the involvement of pyroptosis in the occurrence and development of diverse tumors ...
Jin-Zhou Xu +11 more
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Journal of Translational Medicine, 2022 Background Programmed cell death is an active and orderly form of cell death regulated by intracellular genes that plays an important role in the normal occurrence and development of the immune system, and pyroptosis has been found to be involved in ...
Aibin Liu +4 more
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NLRP3 inflammasome-induced pyroptosis in digestive system tumors
Frontiers in Immunology, 2023 Programmed cell death (PCD) refers to cell death in a manner that depends on specific genes encoding signals or activities. PCD includes apoptosis, pyroptosis, autophagy and necrosis (programmed necrosis).
Jiexia Wen +8 more
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GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis
Nature Communications, 2023 Macrophages have been shown to have an important function in atherosclerosis. Here the authors show that, in human atherosclerotic plaques and mouse models, GSDME and pyroptosis promote atherosclerosis and inhibition of these pathways could reduce ...
Yuanyuan Wei +8 more
semanticscholar +1 more source
Scientific Reports, 2022 Understanding the association of pyroptosis with tumor progression, prognosis and effect on immunotherapeutic response in breast cancer (BC) is limited. This study analysed forty pyroptosis-related genes to construct the pyroptosis score.
Guo Huang +3 more
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