Results 121 to 130 of about 82,547 (381)

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in diabetic retinopathy

Frontiers in Immunology, 2023
In the working-age population worldwide, diabetic retinopathy (DR), a prevalent complication of diabetes, is the main cause of vision impairment. Chronic low-grade inflammation plays an essential role in DR development.
Xiaoqin Zheng, Jia Wan, Gang Tan
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Pyroptosis -related potential diagnostic biomarkers in steroid-induced osteonecrosis of the femoral head

BMC Musculoskeletal Disorders, 2023
Purpose Steroid-induced necrosis of the femoral head (SONFH) is a refractory orthopedic hip disease occurring in young and middle-aged people, with glucocorticoids being the most common cause. Previous experimental studies have shown that cell pyroptosis
Jin-Lian Chai, Bo-Wen Lu, Hai-Tao Du, Ming-Tao Wen, Xue-Zhen Liang, Ping Wang   +5 more
doaj   +1 more source

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome [PDF]

, 2020
Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammasome ...
Atmosukarto, Ines I., Burgio, Gaetan, Feng, Shouya, Fox, Daniel, Fox, Edward M., Hayward, Jenni A., Jessberger, Nadja, Johnson, Matthew D., Kaakoush, Nadeem O., Leppla, Stephen H., Leyton, Denisse L., Liu, Yunqi, Man, Si Ming, Mathur, Anukriti, Märtlbauer, Erwin, Ngo, Chinh, Pandey, Abhimanu, Price, Jason D., Robertson, Avril A. B., Tan, Wei Hong, Tscharke, David C., Xue, Yansong   +21 more
core   +5 more sources

Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis

Science immunology, 2023
Granzyme A from killer lymphocytes cleaves gasdermin B (GSDMB) and triggers pyroptosis in targeted human tumor cells, eliciting antitumor immunity. However, GSDMB has a controversial role in pyroptosis and has been linked to both anti- and protumor ...
Qing Kong, S. Xia, Xingxin Pan, Kaixiong Ye, Zhouyihan Li, Haoyan Li, Xiaoqiang Tang, Nidhi Sahni, S. S. Yi, Xing Liu, Hao Wu, M. Elowitz, J. Lieberman, Zhibin Zhang   +13 more
semanticscholar   +1 more source

From Exciton Dynamics to Cell Fate: A Carbon Dot Based NIR Photocatalytic Platform for Pyroptosis via Self‐Trapped Excitons

Advanced Functional Materials, EarlyView.
A facile and effective method to boost NIR light induced photocatalysis based on nontoxic NIR emissive carbon dots (nir‐CDs) via Self‐trapped excitons, showing that both O2− • and •OH can be generated from nir‐CDs under NIR laser irradiation. Abstract Near‐infrared (NIR) light‐triggered photocatalytic therapy remains a critical challenge in efficient ...
Qingcheng Wang, Quansheng Cheng, Bingzhe Wang, Tesen Zhang, Yupeng Liu, Ruifeng Zheng, Shi Chen, Guichuan Xing, Songnan Qu   +8 more
wiley   +1 more source

Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis

Experimental and Molecular Medicine, 2022
Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of
Weifeng Zhang, Gaocai Li, Rongjin Luo, J. Lei, Yu Song, Bingjin Wang, Liang Ma, Zhiwei Liao, Wencan Ke, Hui Liu, Wenbin Hua, K. Zhao, Xiaobo Feng, Xinghuo Wu, Yukun Zhang, Kun Wang, Cao Yang   +16 more
semanticscholar   +1 more source

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Micro-/nano-structured zirconia surface promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by reducing pyroptosis under inflammatory conditions

Journal of Dental Sciences
Background/purpose: Promoting osteogenesis under inflammatory conditions holds promise for preventing and mitigating peri-implantitis. Cell pyroptosis inhibits osteoblast-mediated bone formation.
Hui-Min Wang, Qian Ding, Ying Chen, Yao-Jun Zhang, Zhi-Xiao Wu, Xiao Zhang, Lei Zhang   +6 more
doaj   +1 more source

Pathogenic effects of inhibition of mTORC1/STAT3 axis facilitates Staphylococcus aureus-induced pyroptosis in human macrophages

Cell Communication and Signaling, 2020
Background Pyroptosis is a recently identified pathway of caspase-mediated cell death in response to microbes, lipopolysaccharide, or chemotherapy in certain types of cells.
Ruiyuan Yao, Yuhao Chen, Huifang Hao, Zhixin Guo, Xiaoou Cheng, Yuze Ma, Qiang Ji, Xiaoru Yang, Yanfeng Wang, Xihe Li, Zhigang Wang   +10 more
doaj   +1 more source