Results 11 to 20 of about 53,940 (298)
Journal of Translational Medicine, 2022 Background Programmed cell death is an active and orderly form of cell death regulated by intracellular genes that plays an important role in the normal occurrence and development of the immune system, and pyroptosis has been found to be involved in ...
Aibin Liu +4 more
doaj +1 more source
Frontiers in Genetics, 2023 The phenotype of pyroptosis has been extensively studied in a variety of tumors, but the relationship between pyroptosis and esophageal squamous cell carcinoma (ESCC) remains unclear. Here, 22 pyroptosis genes were downloaded from the website of Gene Set
Zhan-Fei Zhang, Zhan-Fei Zhang
doaj +1 more source
Methods for monitoring cancer cell pyroptosis
Cancer Biology & Medicine, 2022 Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response.
Shuo Wang +3 more
doaj +1 more source
GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis
Nature Communications, 2023 Macrophages have been shown to have an important function in atherosclerosis. Here the authors show that, in human atherosclerotic plaques and mouse models, GSDME and pyroptosis promote atherosclerosis and inhibition of these pathways could reduce ...
Yuanyuan Wei +8 more
semanticscholar +1 more source
Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer
Cell Death Discovery, 2022 Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely associated with tumour development, but the molecular mechanism underlying ...
Liqing Lu +12 more
doaj +1 more source
NLRP3 inflammasome-induced pyroptosis in digestive system tumors
Frontiers in Immunology, 2023 Programmed cell death (PCD) refers to cell death in a manner that depends on specific genes encoding signals or activities. PCD includes apoptosis, pyroptosis, autophagy and necrosis (programmed necrosis).
Jiexia Wen +8 more
doaj +1 more source
Scientific Reports, 2022 Understanding the association of pyroptosis with tumor progression, prognosis and effect on immunotherapeutic response in breast cancer (BC) is limited. This study analysed forty pyroptosis-related genes to construct the pyroptosis score.
Guo Huang +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Crosstalk between pyroptosis and tumor immune microenvironment (TIME) in cancer has yet to be elucidated. Herein, we aimed to explore the role of pyroptosis and its association with TIME in gastric cancer.
Jie Zhou +23 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundPyroptosis is essential for tumorigenesis and progression of neoplasm. However, the heterogeneity of pyroptosis and its relationship with the tumor microenvironment (TME) in clear cell renal cell carcinoma (ccRCC) remain unclear. The purpose of
Aimin Jiang +11 more
doaj +1 more source
Cell Death and Disease, 2022 Podocyte damage mediated by in situ complement activation in the glomeruli is a key factor in the pathogenesis of membranous nephropathy (MN), but the molecular mechanism has not been fully elucidated.
Hui Wang +17 more
doaj +1 more source