Results 11 to 20 of about 67,989 (334)
Pyroptosis Plays a Role in Osteoarthritis [PDF]
Aging and disease, 2020 Recent studies have revealed novel forms of cell death beyond the canonical types of cellular apoptosis and necrosis, and these novel forms of cell death are induced by extreme microenvironmental factors. Pyroptosis, a type of regulated cell death, occurs when pattern recognition receptors (PRRs) induce the activation of cysteine-aspartic protease 1 ...
Senbo An, Huiyu Hu, Yusheng Li, Yihe Hu
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Harnessing Pyroptosis for Cancer Immunotherapy
CellsCancer immunotherapy is a novel pillar of cancer treatment that harnesses the immune system to fight tumors and generally results in robust antitumor immunity.
Christopher M. Bourne +1 more
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The Role of Mitochondria in Pyroptosis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Pyroptosis is a recently discovered aspartic aspart-specific cysteine protease (Caspase-1/4/5/11) dependent mode of gene-regulated cell death cell death, which is represented by the rupture of cell membrane perforations and the production of proinflammatory mediaters like interleukin-18(IL-18) and interleukin-1β (IL-1β).
Weijun Fu +6 more
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Current Biology, 2016 Injury and physical trauma may inflict accidental cell death, but we have come to realize during the past four decades that cells may also actively engage cell death when needed. These regulated cell death forms are intrinsically connected with human embryonic development, homeostatic maintenance and disease pathology.
Lieselotte, Vande Walle +1 more
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Acta Pharmaceutica Sinica B, 2021 Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection. Excessive pyroptosis, however, leads to several inflammatory diseases, including sepsis and autoimmune disorders. Pyroptosis can be canonical or noncanonical.
Brandon E. Burdette +3 more
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Pyroptosis in Periprosthetic Osteolysis
Biomolecules, 2022 Periprosthetic osteolysis (PPO) along with aseptic loosening (AL) caused by wear particles after artificial joint replacement is the key factor in surgical failure and subsequent revision surgery, however, the precise molecular mechanism underlying PPO remains unclear.
Jian Yin +4 more
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Methods for monitoring cancer cell pyroptosis
Cancer Biology & Medicine, 2022 Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response.
Shuo Wang +3 more
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Journal of Molecular Biology, 2022 In the last several decades, apoptosis interference has been considered clinically irrelevant in the context of renal injury. Recent discovery of programmed necrotic cell death, including necroptosis, ferroptosis, and pyroptosis refreshed our understanding of the role of cell death in kidney disease.
Yujia Wang, Yanfang Xu, Yinshuang Li
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Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer
Cell Death Discovery, 2022 Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely associated with tumour development, but the molecular mechanism underlying ...
Liqing Lu +12 more
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Pyroptosis in pterygium pathogenesis [PDF]
Bioscience Reports, 2018 Pterygium is a common ocular disease characterized by proliferating fibrovascular tissue. Pyroptosis, a recently discovered programed cell death, is known to be associated with oxidative stress, one of the main causes of pterygia. Here, we aimed to study the role of pyroptosis in pterygium pathogenesis.
Naiyu Sun, Hong Zhang
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