Results 11 to 20 of about 63,272 (185)
Harnessing Pyroptosis for Cancer Immunotherapy
CellsCancer immunotherapy is a novel pillar of cancer treatment that harnesses the immune system to fight tumors and generally results in robust antitumor immunity.
Christopher M. Bourne +1 more
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Current Biology, 2016 Injury and physical trauma may inflict accidental cell death, but we have come to realize during the past four decades that cells may also actively engage cell death when needed. These regulated cell death forms are intrinsically connected with human embryonic development, homeostatic maintenance and disease pathology.
Lieselotte, Vande Walle +1 more
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NLRP3 inflammasome-induced pyroptosis in digestive system tumors
Frontiers in Immunology, 2023 Programmed cell death (PCD) refers to cell death in a manner that depends on specific genes encoding signals or activities. PCD includes apoptosis, pyroptosis, autophagy and necrosis (programmed necrosis).
Jiexia Wen +8 more
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Methods for monitoring cancer cell pyroptosis
Cancer Biology & Medicine, 2022 Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response.
Shuo Wang +3 more
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Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer
Cell Death Discovery, 2022 Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely associated with tumour development, but the molecular mechanism underlying ...
Liqing Lu +12 more
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Pyroptosis-Mediated Periodontal Disease [PDF]
International Journal of Molecular Sciences, 2021 Pyroptosis is a caspase-dependent process relevant to the understanding of beneficial host responses and medical conditions for which inflammation is central to the pathophysiology of the disease. Pyroptosis has been recently suggested as one of the pathways of exacerbated inflammation of periodontal tissues.
Mariane Beatriz Sordi +3 more
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Induction of Pyroptosis: A Promising Strategy for Cancer Treatment
Frontiers in Oncology, 2021 Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied in diverse inflammatory disease models. Membrane perforation and cell swelling induced by cleaved gasdermin family members is the main characteristic of ...
Lei Wang +3 more
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Journal of Molecular Biology, 2022 In the last several decades, apoptosis interference has been considered clinically irrelevant in the context of renal injury. Recent discovery of programmed necrotic cell death, including necroptosis, ferroptosis, and pyroptosis refreshed our understanding of the role of cell death in kidney disease.
Yujia, Wang, Yinshuang, Li, Yanfang, Xu
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Frontiers in Oncology, 2021 BackgroundPyroptosis is essential for tumorigenesis and progression of neoplasm. However, the heterogeneity of pyroptosis and its relationship with the tumor microenvironment (TME) in clear cell renal cell carcinoma (ccRCC) remain unclear. The purpose of
Aimin Jiang +11 more
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Frontiers in Cell and Developmental Biology, 2022 Crosstalk between pyroptosis and tumor immune microenvironment (TIME) in cancer has yet to be elucidated. Herein, we aimed to explore the role of pyroptosis and its association with TIME in gastric cancer.
Jie Zhou +23 more
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