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Induction of Pyroptosis: A Promising Strategy for Cancer Treatment
Frontiers in Oncology, 2021 Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied in diverse inflammatory disease models. Membrane perforation and cell swelling induced by cleaved gasdermin family members is the main characteristic of ...
Lei Wang +3 more
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Pyroptosis in pterygium pathogenesis [PDF]
Bioscience Reports, 2018 Pterygium is a common ocular disease characterized by proliferating fibrovascular tissue. Pyroptosis, a recently discovered programed cell death, is known to be associated with oxidative stress, one of the main causes of pterygia. Here, we aimed to study the role of pyroptosis in pterygium pathogenesis.
Naiyu Sun, Hong Zhang
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Frontiers in Oncology, 2021 BackgroundPyroptosis is essential for tumorigenesis and progression of neoplasm. However, the heterogeneity of pyroptosis and its relationship with the tumor microenvironment (TME) in clear cell renal cell carcinoma (ccRCC) remain unclear. The purpose of
Aimin Jiang +11 more
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Apoptosis, 2023 Pyroptosis could be responsible for the bone loss from bone metabolic diseases, leading to the negative impact on people's health and life. It has been shown that osteoclasts, osteoblasts, macrophages, chondrocytes, periodontal and gingival cells may be involved in bone loss linked with pyroptosis.
Li, Xinyi +6 more
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Frontiers in Cell and Developmental Biology, 2022 Crosstalk between pyroptosis and tumor immune microenvironment (TIME) in cancer has yet to be elucidated. Herein, we aimed to explore the role of pyroptosis and its association with TIME in gastric cancer.
Jie Zhou +23 more
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Pyroptosis at the forefront of anticancer immunity [PDF]
Journal of Experimental & Clinical Cancer Research, 2021 AbstractTumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two major contributors to poor therapeutic responses during cancer intervention. Pyroptosis, a lytic and inflammatory programmed cell death pathway distinct from apoptosis, has subsequently sparked notable interest among cancer researchers for its potential to be
Reid Loveless +2 more
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Cell Death and Disease, 2022 Podocyte damage mediated by in situ complement activation in the glomeruli is a key factor in the pathogenesis of membranous nephropathy (MN), but the molecular mechanism has not been fully elucidated.
Hui Wang +17 more
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The Molecular Pathways of Pyroptosis in Atherosclerosis [PDF]
Frontiers in Cell and Developmental Biology, 2022 Atherosclerosis (AS) is a chronic inflammatory disease seriously endangering human health, whose occurrence and development is related to many factors. Pyroptosis is a recently identified novel programmed cell death associated with an inflammatory response and involved in the formation and progression of AS by activating different signaling pathways ...
Dan Song +7 more
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Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome
Frontiers in Physiology, 2022 Pyroptosis plays a crucial role in a variety of human diseases, including atherosclerosis, obesity, diabetes, depression, and Alzheimer’s disease, which usually release pyroptosis-related cytokines due to inflammation. Many studies have demonstrated that
Shujuan Hu +4 more
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Pyroptosis in the Initiation and Progression of Atherosclerosis [PDF]
Frontiers in Pharmacology, 2021 Pyroptosis, a newly discovered form of programmed cell death, is characterized by cell swelling, the protrusion of large bubbles from the plasma membrane and cell lysis. This death pathway is mediated by the pore formation of gasdermin D (GSDMD), which is activated by human caspase-1/caspase-4/caspase-5 (or mouse caspase-1/caspase11), and followed with
Zhengtao Qian +9 more
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