Results 21 to 30 of about 53,940 (298)

Induction of Pyroptosis: A Promising Strategy for Cancer Treatment

Frontiers in Oncology, 2021
Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied in diverse inflammatory disease models. Membrane perforation and cell swelling induced by cleaved gasdermin family members is the main characteristic of ...
Lei Wang, Xiaowei Qin, Jianmin Liang, Pengfei Ge   +3 more
doaj   +1 more source

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Signal Transduction and Targeted Therapy, 2022
In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors respond poorly or even not to ICIs, partly caused by the absence of tumor ...
W. Gao, Xuepeng Wang, Yang Zhou, Xuepeng Wang, Yan Yu   +4 more
semanticscholar   +1 more source

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

Journal of Hematology & Oncology, 2022
Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various biological activities, including the clearance of ...
Xuhui Tong, Ronghua Tang, Mingming Xiao, Jin Xu, Wei Wang, Bo Zhang, Jiang Liu, Xianjun Yu, S. Shi   +8 more
semanticscholar   +1 more source

Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome

Frontiers in Physiology, 2022
Pyroptosis plays a crucial role in a variety of human diseases, including atherosclerosis, obesity, diabetes, depression, and Alzheimer’s disease, which usually release pyroptosis-related cytokines due to inflammation. Many studies have demonstrated that
Shujuan Hu, Shujuan Hu, Xingxia Wan, Xianhui Li, Xianwang Wang   +4 more
doaj   +1 more source

Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice

Nature Communications, 2023
Parabacteroides distasonis ( P. distasonis ) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P.
Qi Zhao, Manyun Dai, Ruoyue Huang, Jingyi Duan, Ting Zhang, Weimin Bao, Jing-Yi Zhang, Shao-Qiang Gui, Shu-Min Xia, Cong-Ting Dai, Ying-mei Tang, F. Gonzalez, Fei Li   +12 more
semanticscholar   +1 more source

Role of pyroptosis in inflammation and cancer

Cellular & Molecular Immunology, 2022
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures, resulting in the release of cellular contents that can activate strong inflammatory and immune responses ...
Xiang Wei, Feng Xie, Xiaoxue Zhou, Yuchen Wu, Haiyan Yan, Ting Liu, Jun Huang, Fangwei Wang, Fangfang Zhou, Long Zhang   +9 more
semanticscholar   +1 more source

Pyroptosis in inflammatory diseases and cancer

Theranostics, 2022
Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered by inflammasomes and executed by gasdermin proteins. The main characteristics of pyroptosis are cell swelling, membrane perforation, and the release of cell ...
Zhiping Rao, Yutong Zhu, Peng Yang, Zhuang Chen, Yuqiong Xia, Chaoqiang Qiao, Wei-Jing Liu, H. Deng, Jian-xiong Li, P. Ning, Zhongliang Wang   +10 more
semanticscholar   +1 more source

Mesenchymal stem cells protect against TBI-induced pyroptosis in vivo and in vitro through TSG-6

Cell Communication and Signaling, 2022
Background Pyroptosis, especially microglial pyroptosis, may play an important role in central nervous system pathologies, including traumatic brain injury (TBI). Transplantation of mesenchymal stem cells (MSCs), such as human umbilical cord MSCs (hUMSCs)
Zhiming Feng, Shiting Hua, Wangan Li, Jianbang Han, Feng Li, Haijia Chen, Zhongfei Zhang, Yu Xie, Qian Ouyang, Xiaoxiong Zou, Zhizheng Liu, Cong Li, Sixian Huang, Zelin Lai, Xiaolin Cai, Yingqian Cai, Yuxi Zou, Yanping Tang, Xiaodan Jiang   +18 more
doaj   +1 more source

ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis

Frontiers in Immunology, 2022
The endothelium is a single layer of epithelium covering the surface of the vascular system, and it represents a physical barrier between the blood and vessel wall that plays an important role in maintaining intravascular homeostasis.
Dongdong Zheng, Jia Liu, Hulin Piao, Zhicheng Zhu, Ran Wei, Kexiang Liu   +5 more
semanticscholar   +1 more source

The role of pyroptosis and its crosstalk with immune therapy in breast cancer

Frontiers in Immunology, 2022
Pyroptosis is a brand-new category of programmed cell death (PCD) that is brought on by multitudinous inflammasomes, which can recognize several stimuli to pilot the cleavage of and activate inflammatory cytokines like IL-18 and IL-1β is believed to have
Ling Wu, Ling Wu, Hongsheng Lu, Yin Pan, Chen Liu, Jinyan Wang, Baofu Chen, Yichao Wang   +7 more
doaj   +1 more source