Results 31 to 40 of about 77,046 (386)
Gasdermins: Effectors of Pyroptosis [PDF]
Trends in Cell Biology, 2017 Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor domain (RD).
Stephen B. Kovacs, Edward A. Miao
openaire +3 more sources
Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María +3 more
core +1 more source
Nature Communications, 2023 Parabacteroides distasonis ( P. distasonis ) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P.
Qi Zhao +12 more
semanticscholar +1 more source
The role of pyroptosis and its crosstalk with immune therapy in breast cancer
Frontiers in Immunology, 2022 Pyroptosis is a brand-new category of programmed cell death (PCD) that is brought on by multitudinous inflammasomes, which can recognize several stimuli to pilot the cleavage of and activate inflammatory cytokines like IL-18 and IL-1β is believed to have
Ling Wu +7 more
doaj +1 more source
ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr +4 more
core +1 more source
Pyroptosis Induction and Detection [PDF]
Current Protocols in Immunology, 2018 AbstractPyroptosis is a form of programmed pro‐inflammatory cell death that plays a protective role in the host response to infection, but can also promote pathogenic inflammation. Pyroptosis is mediated by the cysteine protease, caspase‐1. Caspase‐1 cleaves gasdermin D, releasing the N‐terminal pore‐forming domain, which inserts into the plasma ...
Andreas B. den Hartigh, Susan L. Fink
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Mesenchymal stem cells protect against TBI-induced pyroptosis in vivo and in vitro through TSG-6
Cell Communication and Signaling, 2022 Background Pyroptosis, especially microglial pyroptosis, may play an important role in central nervous system pathologies, including traumatic brain injury (TBI). Transplantation of mesenchymal stem cells (MSCs), such as human umbilical cord MSCs (hUMSCs)
Zhiming Feng +18 more
doaj +1 more source
NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease. [PDF]
, 2017 Inflammasomes are cytosolic multiprotein complexes that initiate protective immunity in response to infection, and can also drive auto-inflammatory diseases, but the cell types and signalling pathways that cause these diseases remain poorly understood ...
Nichols, Randilea D +2 more
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Approaching Neutrophil Pyroptosis
Journal of Molecular Biology, 2022 All cells must die at some point, and the dogma is that they do it either silently via apoptosis or via pro-inflammatory, lytic forms of death. Amongst these lytic cell death pathways, pyroptosis is one of the best characterized. Pyroptosis depends on inflammatory caspases which activate members of the gasdermin family of proteins, and it is associated
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Cancer Medicine, 2023 Immunotherapy has greatly improved outcomes for patients with advanced melanoma, but good predictive biomarkers remain lacking in clinical practice. Although increasing evidence has revealed a vital role of pyroptosis in the tumor microenvironment (TME),
Guanghao Wu +5 more
doaj +1 more source