Results 31 to 40 of about 53,940 (298)
Frontiers in Oncology, 2022 BackgroundIt is well known that chronic inflammation can promote the occurrence and progression of cancer. As a type of proinflammatory death, pyroptosis can recast a suitable microenvironment to promote tumor growth.
Xi Zhang +7 more
doaj +1 more source
Nature Communications, 2023 Immunogenic programmed cell death, such as pyroptosis and ferroptosis, efficiently induces an acute inflammatory response and boosts antitumor immunity.
Liang Zhang +11 more
semanticscholar +1 more source
Cancer Medicine, 2023 Immunotherapy has greatly improved outcomes for patients with advanced melanoma, but good predictive biomarkers remain lacking in clinical practice. Although increasing evidence has revealed a vital role of pyroptosis in the tumor microenvironment (TME),
Guanghao Wu +5 more
doaj +1 more source
Lipid metabolism in pancreatic cancer: emerging roles and potential targets
Cancer Communications, Volume 42, Issue 12, Page 1234-1256, December 2022., 2022 Abstract Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5‐year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection.
Xinpeng Yin +6 more
wiley +1 more source
Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors
Frontiers in Immunology, 2023 Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the ...
Zhen Dai +5 more
semanticscholar +1 more source
HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis
BMC Molecular and Cell Biology, 2023 Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear.
Jiawei Shang +5 more
doaj +1 more source
Frontiers in Genetics, 2022 Background: Due to high heterogeneity and mortality of low-grade gliomas (LGGs), it is of great significance to find biomarkers for prognosis and immunotherapy.
Zijian Zhou +6 more
doaj +1 more source
Cancer Medicine, Volume 11, Issue 24, Page 5097-5112, December 2022., 2022 our findings robustly demonstrate that our constructed prlncRNA signature could serve as an efficient indicator of prognosis, immunotherapy response, and chemosensitivity for HNSCC patients. Abstract Background Pyroptosis plays an essential function in carcinogenesis and the antitumor immune response.
Chongchang Zhou +6 more
wiley +1 more source
Advanced NanoBiomed Research, 2023 Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two main reasons for the poor outcomes of tumor treatment. Pyroptosis is a newly discovered form of programmed cell death, featuring surprising proinflammatory activity ...
Yuan Ding +4 more
doaj +1 more source
Cancer Medicine, Volume 11, Issue 24, Page 5129-5144, December 2022., 2022 We built and verified a risk model for HNSCC prognosis using 7 pyroptosis‐related signature genes, which could facilitate the implementation of the HNSCC treatment. Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a life‐threatening disease with poor prognosis.
Zhanzhan Li +4 more
wiley +1 more source