Results 51 to 60 of about 42,330 (202)
Pyroptosis in spinal cord injury
Frontiers in Cellular Neuroscience, 2022 Spinal cord injury (SCI) often brings devastating consequences to patients and their families. Pathophysiologically, the primary insult causes irreversible damage to neurons and glial cells and initiates the secondary damage cascade, further leading to inflammation, ischemia, and cells death.
Jian Yin +4 more
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The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases
Cell Death Discovery, 2022 Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome activation, pore formation, and cell lysis. According to different caspases, pyroptosis can be divided into canonical, non-canonical, and other pathways. The role of
Siyu Wang +6 more
doaj +1 more source
Frontiers in Genetics, 2022 Clear cell renal cell carcinoma (ccRCC) is a common urinary system malignant tumor with a high incidence and recurrence rate. Pyroptosis is a kind of programmed cell death caused by inflammasomes.
Ming Zhong +10 more
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Pyroptosis as a candidate therapeutic target for Alzheimer’s disease
Frontiers in Aging Neuroscience, 2022 Pyroptosis is a form of cell death mediated by inflammasomes and gasdermins, and the relevance of pyroptosis to neurodegenerative diseases is currently receiving increasing attention.
Yuehua Huang +10 more
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Inhibition of macrophage pyroptosis ameliorates silica-induced pulmonary fibrosis
Ecotoxicology and Environmental Safety, 2023 Macrophage pyroptosis has recently been involved in some inflammatory and fibrosis diseases, however, the role of macrophage pyroptosis in silica-induced pulmonary fibrosis has not been fully elucidated.
Fuyang Jiang +9 more
doaj
A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the effects of anti-inflammatory intervention [PDF]
arXiv, 2020 Pyroptosis is an inflammatory mode of cell death that can contribute to the cytokine storm associated with severe cases of coronavirus disease 2019 (COVID-19). The formation of the NLRP3 inflammasome is central to pyroptosis, which may be induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
arxiv
Pyroptosis: Physiological roles in viral infection [PDF]
arXiv, 2020 The current review focuses on important aspects of pyroptosis, such as morphological features of inflammasomes, as well as on knowledge about coronavirus infection mechanisms and the association between SARS-CoV-2 infection and cell pyroptosis. The application of immunomodulation therapies to Covid-19 patients is the most promising treatment under ...
arxiv
Relationship of EGFR-TKI Targeted Therapy and Pyroptosis in Non-small Cell Lung Cancer
Zhongliu Fangzhi Yanjiu, 2023 Objective To explore the relationship between pyroptosis and treatment in non-small cell lung cancer patients treated with tyrosine kinase inhibitors targeted therapy.
CHEN Jiachen, WU Tingyu, XIA Weiliang
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Pyroptosis and degenerative diseases of the elderly
Cell Death & Disease, 2023 AbstractPyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent gasdermin D pathways. Additional pyroptotic pathways have been subsequently reported.
Jiamin Zhou +8 more
openaire +3 more sources
The implication of pyroptosis in cancer immunology: Current advances and prospects
Genes and Diseases, 2023 Pyroptosis is a regulated cell death pathway involved in numerous human diseases, especially malignant tumors. Recent studies have identified multiple pyroptosis-associated signaling molecules, like caspases, gasdermin family and inflammasomes.
Wei Liu +11 more
doaj