Results 51 to 60 of about 77,046 (386)

Role of pyroptosis in inflammation and cancer

Cellular & Molecular Immunology, 2022
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures, resulting in the release of cellular contents that can activate strong inflammatory and immune responses ...
Xiang Wei, Feng Xie, Xiaoxue Zhou, Yuchen Wu, Haiyan Yan, Ting Liu, Jun Huang, Fangwei Wang, Fangfang Zhou, Long Zhang   +9 more
semanticscholar   +1 more source

Pyroptosis in inflammatory diseases and cancer

Theranostics, 2022
Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered by inflammasomes and executed by gasdermin proteins. The main characteristics of pyroptosis are cell swelling, membrane perforation, and the release of cell ...
Zhiping Rao, Yutong Zhu, Peng Yang, Zhuang Chen, Yuqiong Xia, Chaoqiang Qiao, Wei-Jing Liu, H. Deng, Jian-xiong Li, P. Ning, Zhongliang Wang   +10 more
semanticscholar   +1 more source

Pyroptosis in liver disease

Revista Española de Enfermedades Digestivas, 2020
Pyroptosis is an inflammatory cell death process that is dependent on caspase. Pyroptosis is a specific form of programmed cell death with the morphological characteristics of formation of pores on the cell membrane, cell swelling, and rupture of the plasma membrane.
Shihe Jang, Wang Zeyu, Yong Jiang, Binghua Liu, Lijuan Zhang, Zhiguang Zhang   +5 more
openaire   +2 more sources

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome [PDF]

, 2020
Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammasome ...
Atmosukarto, Ines I., Burgio, Gaetan, Feng, Shouya, Fox, Daniel, Fox, Edward M., Hayward, Jenni A., Jessberger, Nadja, Johnson, Matthew D., Kaakoush, Nadeem O., Leppla, Stephen H., Leyton, Denisse L., Liu, Yunqi, Man, Si Ming, Mathur, Anukriti, Märtlbauer, Erwin, Ngo, Chinh, Pandey, Abhimanu, Price, Jason D., Robertson, Avril A. B., Tan, Wei Hong, Tscharke, David C., Xue, Yansong   +21 more
core   +5 more sources

ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis

Frontiers in Immunology, 2022
The endothelium is a single layer of epithelium covering the surface of the vascular system, and it represents a physical barrier between the blood and vessel wall that plays an important role in maintaining intravascular homeostasis.
Dongdong Zheng, Jia Liu, Hulin Piao, Zhicheng Zhu, Ran Wei, Kexiang Liu   +5 more
semanticscholar   +1 more source

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. [PDF]

, 2019
Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane.
Alnemri, Emad S., Aplin, Andrew E., Erkes, Dan A., Fernandes-Alnemri, Teresa, Nardone, Alexandria, Rogers, Corey   +5 more
core   +3 more sources

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. [PDF]

, 2006
To restrict infection by Legionella pneumophila, mouse macrophages require Naip5, a member of the nucleotide-binding oligomerization domain leucine-rich repeat family of pattern recognition receptors, which detect cytoplasmic microbial products.
Byrne, Brenda G, Fuse, Etsu T, Madigan, Cressida A, Molofsky, Ari B, Swanson, Michele S, Tateda, Kazuhiro, Whitfield, Natalie N   +6 more
core   +2 more sources

Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors

Frontiers in Immunology, 2023
Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the ...
Zhen Dai, Wanfa Liu, Xiao-Yi Chen, Xiao Wang, Jun‐Long Li, Xiang Zhang   +5 more
semanticscholar   +1 more source

Targeting pyroptosis as a preventive and therapeutic approach for stroke

Cell Death Discovery, 2023
Stroke has caused tremendous social stress worldwide, yet despite decades of research and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue plasminogen activator) is still the accepted treatment for ischemic stroke.
Junpeng Long, Yang Sun, Shasha Liu, Songwei Yang, Chen Chen, Zhao Zhang, Shi-Feng Chu, Yantao Yang, G. Pei, Mei-yu Lin, Qian Yan, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, Naihong Chen   +17 more
semanticscholar   +1 more source

A single cut to pyroptosis

Oncotarget, 2015
Pyroptosis is a form of inflammatory cell death mediated by inflammatory caspases. Two independent studies have recently demonstrated that inflammatory caspases cleave gasdermin D and the resulting N-terminal fragment of this protein mediates pyroptosis. Here we summarize the key findings reported in these important publications.
Yoon Lim, Sharad Kumar
openaire   +4 more sources