Results 51 to 60 of about 67,989 (334)

NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. [PDF]

, 2016
NLRs (nucleotide-binding domain [NBD] leucine-rich repeat [LRR]-containing proteins) exhibit diverse functions in innate and adaptive immunity.
Al Moussawi, Khatoun, Kang, Chulho, Kang, James J, Kazmierczak, Barbara I, Nichols, Randilea D, Rauch, Isabella, Tenthorey, Jeannette L, Vance, Russell E   +7 more
core   +1 more source

Novel insights into host-fungal pathogen interactions derived from live-cell imaging [PDF]

, 2015
Acknowledgments The authors acknowledge funding from the Wellcome Trust (080088, 086827, 075470 and 099215) including a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377 and FP7-2007–2013 grant agreement HEALTH-F2-2010 ...
A Casadevall, AK Neumann, B Amulic, B Enjalbert, B Hube, BN Gantner, C Jiménez-López, C Sasse, C Tokarski, CC Sheth, CF Urban, CGJ McKenzie, CJ Chrisman, D Armstrong-James, D Ermert, D Liebl, D Vijayan, DA Silva da, DC Savage, DJ Krysan, E Moreno-Ruiz, EK Szabo, FM Rudkin, G Chamilos, G Vande Velde, GD Brown, GD Brown, H Ma, H Ma, I Rubin-Bejerano, IE Frohner, J Behnsen, J Chandra, J Maertens, J Perlroth, J Voigt, JM Bain, JM Tam, Judith Bain, K Konig, K Schäfer, K Seider, KM Brothers, L Romani, L Romani, Lars-Peter Erwig, LE Lewis, LE Lewis, LG Tilney, LY Ngo, M Alvarez, MC Lorenz, MG Netea, MJ Patterson, MS Lionakis, MS Lionakis, N Papon, NAR Gow, Neil A. R. Gow, O Uzun, O Zaragoza, P Martino, P Miramón, Q Qian, R García-Rodas, RA Drummond, RD Diamond, RI Lehrer, S Bruns, S El-Kirat-Chatel, S Keppler-Ross, S Mitra, SA Johnston, SC Cheng, SE Heinsbroek, V Aimanianda, Wellington, Y Luo   +77 more
core   +1 more source

A single cut to pyroptosis

Oncotarget, 2015
Pyroptosis is a form of inflammatory cell death mediated by inflammatory caspases. Two independent studies have recently demonstrated that inflammatory caspases cleave gasdermin D and the resulting N-terminal fragment of this protein mediates pyroptosis. Here we summarize the key findings reported in these important publications.
Yoon Lim, Sharad Kumar
openaire   +4 more sources

Pyroptosis and inflammasomes in cancer and inflammation

MedComm, 2023
AbstractNonprogrammed cell death (NPCD) and programmed cell death (PCD) are two types of cell death. Cell death is significantly linked to tumor development, medication resistance, cancer recurrence, and metastatic dissemination. Therefore, a comprehensive understanding of cell death is essential for the treatment of cancer. Pyroptosis is a kind of PCD
Jie‐Lin Wang, Sheng‐Ni Hua, Hai‐Juan Bao, Jing Yuan, Yang Zhao, Shuo Chen   +5 more
openaire   +3 more sources

Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma

Scientific Reports, 2023
Pyroptosis is a kind of programmed cell death triggered by the inflammasome. Growing evidence has revealed the crucial utility of pyroptosis in tumors.
Jiayi Zeng, Ping Zhu, Yanlin Tang, Changzheng Zhang, Chujin Ye, Shouyu Cheng, Kaiwen Tian, Bowen Yang, Weinan Zeng, Yanjun Liu, Zhiyong Xian, Yuming Yu   +11 more
doaj   +1 more source

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources

Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats

Mediators of Inflammation, 2023
Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases ...
Jiayi Wang, Shunyi Lu, Ya Yuan, Lei Huang, Mengxuan Bian, Jieqin Yu, Jiapeng Zou, Libo Jiang, Dehua Meng, Jian Zhang   +9 more
doaj   +1 more source

The role of pyroptosis in cognitive impairment

Frontiers in Neuroscience, 2023
Cognitive impairment is a major global disease, manifests as a decline in cognitive functioning and endangers the health of the population worldwide. The incidence of cognitive impairment has increased rapidly with an increasingly aging population.
Xin Yang, Zhe Tang
openaire   +3 more sources

HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis

BMC Molecular and Cell Biology, 2023
Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear.
Jiawei Shang, Feng Zhao, Yongmei Cao, Feng Ping, Wei Wang, Yingchuan Li   +5 more
doaj   +1 more source

Regulation of Pyroptosis by ncRNA: A Novel Research Direction

Frontiers in Cell and Developmental Biology, 2022
Pyroptosis is a novel form of programmed cell death (PCD), which is characterized by DNA fragmentation, chromatin condensation, cell swelling and leakage of cell contents.
Liyuan Gao, Zhitao Jiang, Yi Han, Yang Li, Xiang Yang   +4 more
doaj   +1 more source