Results 131 to 140 of about 70,546 (390)

Crystal structure of ethyl 1′,5-dimethyl-2′′,3-dioxo-3H-dispiro[benzo[b]thiophene-2,3′-pyrrolidine-2′,3′′-indoline]-4′-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C23H22N2O4S, crystallized with two independent molecules (A and B) in the asymmetric unit. They have very similar conformations with the pyrrolidine ring having a twisted conformation, on the Cspiro—Cspiro bond, in both molecules.
R. Raja, J. Govindaraj, M. Suresh, R. Raghunathan, A. SubbiahPandi   +4 more
doaj   +1 more source

Diversity oriented synthesis : substitution at C5 in unreactive pyrimidines by Claisen rearrangement and reactivity in nucleophilic substitution at C2 and C4 in pteridines and pyrido[2,3-d]pyrimidines [PDF]

, 2011
Diversity oriented synthesis of fused pyrimidines leads to scaffolds with many biological activities. In the case of the preparation of pyrido[2,3-d]pyrimidines from 2-alkylthiopyrimidines, the formation of a new carbon-carbon bond at C5 is required, a ...
Adcock, Jonathan Paul, Gibson, Colin, Huggan, Judith, Suckling, Colin   +3 more
core   +1 more source

Stereochemical Studies on a New Ciramadol Analogue by NMR-Spectroscopy [PDF]

, 1994
The absol. configuration of a Ciramadol analogue obtained from (-)-menthone is established by 'H-NMR-. simulated NMR-, COSY-90-, and NOEmeasurements. The final compound 2-(a-1 -pyrrolidino)benzy 1-4-isopropyl- 1 -methyl-cyclohexan-3-one (4b), e.g..
Akgün, H., Burgemeister, Thomas, Ertan, M., Wiegrebe, Wolfgang, Özarslan, Ö.   +4 more
core  

Three-electron two-centred bonds and the stabilisation of cationic sulfur radicals [PDF]

, 2014
Electronic communication in biological systems is fundamental to understanding protein signalling and electron hopping pathways. Frequently studied examples are cationic radical methionine and its functional derivatives.
Carbery, DR, Hendon, CH, Walsh, A
core   +1 more source

15-(4-Chlorophenyl)-6b-hydroxy-17-methyl-6b,7,16,17-tetrahydro-7,14a-methanonaphtho[1′,8′:1,2,3]pyrrolo[3′,2′:8,8a]azuleno[5,6-b]quinolin-14(15H)-one methanol hemisolvate

IUCrData, 2016
In the title solvate, C35H25ClN2O3·0.5CH3OH, the conformation of the central 1-methylpyrrolidine ring is best described as an envelope with the N atom as the flap.
J. M. Joseph, Vijayan Viswanathan, Devadasan Velmurugan   +2 more
doaj   +1 more source

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells. [PDF]

, 1997
Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB ...
Algarté M., Aramburu J., Baeuerle P. A., Baichwal V. R., Beals C. R., Beg A. A., Bessho R., Boise L. H., Burns G. F., Chuvpilo S. D., Cockerill P. N., Cockerill P. N., Cotter T. G., Crabtree G. R., Crabtree G. R., Durand D. B., Goldfeld A. E., Gómez del Arco P., Hibi M., Ho S. N., Ho S. N., Hodge M. R., Hoey T., Izquierdo M., Jain J., Jain J., Lee H. J., Liu J., Loh C., Los M., Luo C., Luo C., Luo C., Masuda E. S., Masuda E. S., Mauri N., McCaffrey P. G., Meyer M., Minden A., Muoz C., Muoz C., Nobel C. S. I., Northrop J. P., Prieschl E. E., Radler-Pohl A., Rao A., Reisinger E. C., Rooney J. W., Ruff V. A., Schenk H., Schreck R., Schreck R., Schreiber E., Schreiber S. L., Schulze-Osthoff K., Schulze-Osthoff K., Sen C. K., Shaw J. P., Shaw K. T., Shibasaki F., Spits H., Staal F. J. T., Szabo S. J., Sánchez-Mateos P., Timmerman L. A., Traenckner E.B., Truneh A., Van Antwerp D. J., Wang C., Weiss A., Wu M., Xanthoudakis S., Yano O.   +72 more
core   +3 more sources

Simultaneous Broadband Suppression of Homonuclear and Heteronuclear Couplings in 1H NMR Spectroscopy

ChemPhysChem, Volume 23, Issue 24, December 16, 2022., 2022
Ultra‐high resolution 1H NMR spectra are obtained by simultaneous broadband suppression of both homonuclear and heteronuclear scalar couplings, giving a fully pure shift 1H NMR spectrum containing chemical shift information only. The analysis of a range of fluorine‐ and phosphorus‐containing systems highlights how this method can be used to aid the ...
Coral Mycroft, Mathias Nilsson, Gareth A. Morris, Laura Castañar   +3 more
wiley   +1 more source

Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome. [PDF]

, 2019
Dravet syndrome is a life-threatening early-onset epilepsy not well controlled by antiepileptic drugs. Drugs that modulate serotonin (5-HT) signalling, including clemizole, locaserin, trazodone and fenfluramine, have recently emerged as potential ...
Baraban, Scott C, Grandjean, Jean-Marc, Griffin, Aliesha L, Jaishankar, Priyadarshini, Olson, Steven H, Renslo, Adam R   +5 more
core   +1 more source

Organocatalytic Enantioselective Cascade Aza‐Michael/Michael Addition Sequence for Asymmetric Synthesis of Chiral Spiro[pyrrolidine‐3,3′‐oxindole]s

, 2015
The spiro[pyrrolidine-3,3′-oxindole] scaffold is common to a range of bioactive compounds; however, the asymmetric synthesis of this scaffold is complicated due to the presence of multiple chiral centers. An organocatalytic asymmetric cascade aza-Michael/
Bo-Liang Zhao, D. Du
semanticscholar   +1 more source

Purification and structure elucidation of three naturally bioactive molecules from the new terrestrial Streptomyces sp. TN17 strain [PDF]

, 2011
Thirty litres of fermentation broth was extracted from the newly isolated Streptomyces sp. strain TN17 and various separation and purification steps led to the isolation of three pure bioactive compounds (1–3).
Coppel, Yannick, Fourati Ben Fguira, Lilia, Lebrihi, Ahmed, Mathieu, Florence, Mellouli, Lofti, Smaoui, Slim   +5 more
core   +2 more sources