Results 121 to 130 of about 13,199 (173)
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Excess enthalpy. Pyrrolidine-cyclohexane system
, 1986 A data table and a correlation equation are presented for the excess enthalpies of the pyrrolidine-cyclohexane system, single-phase, both components liq.
CECCANTI, NORBERTO +2 more
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Nucleophilic Aromatic Substitution in the Gas Phase
Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.In this review, we highlight experimental studies of gas‐phase SNAr. Studying reactions in the gas phase provides invaluable information on intrinsic reactivity by eliminating the complications of solvent effects. Because SNAr is a fundamental reaction in chemical research and organic synthesis, understanding its underlying reactivity and mechanisms is
Daniel N. Hirsch +2 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 22, Page 6718-6734, November 2026.NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness +21 more
wiley +1 more source
New 2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol derivatives were synthesized from (5S)-5-[(trityloxy)methyl]pyrrolidin-2-one (6) (Schemes 1 and 2) and their inhibitory activities toward 25 glycosidases assayed (Table).
Gerber-Lemaire, S +3 more
core +1 more source
ChemMedChem, Volume 21, Issue 20, 28 October 2026.A series of 12 novel fused [6,6] saturated and unsaturated nitrogen bicycles is synthesized in three to five steps and expands the CRAFT library's fragment space. A 2,6‐naphthyridin‐3‐ol core replaces the dihydroquinolinone scaffold of aripiprazole, a scaffold‐hopping strategy.
Temitayo Omowumi Alegbejo Price +12 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.The successful extension of the nickel‐catalyzed asymmetric coupling of polarized 1,3‐dienes with aldehydes to an intramolecular setting opens an efficient new entry into hydroxylated N‐heterocyclic compounds, most notably valuable tetrahydroisoquinolines.
Thilo Bender +3 more
wiley +2 more sources
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.Modifying the conformational ensemble of “molten‐globule” protein by the site‐specific incorporation of stereoisomeric 4‐fluoroproline residues modulated its binding affinity and aggregation behavior. 19F NMR spectroscopy enabled the detection of key interactions responsible for structural and dynamic changes. ABSTRACT Recently, the application of deep
Abir Ben Bouzayene +5 more
wiley +2 more sources
Counterion Effects in Decatungstate Photocatalysis
European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.Decatungstate photocatalysis is often discussed from an anion‐centered perspective, treating the counterion as a passive charge‐balancing species. This review highlights that counterion identity can instead profoundly influence catalyst solubility, ion pairing, aggregation, stability, substrate accessibility, and catalytic performance.
Florence Babawale +2 more
wiley +1 more source
Excess Gibbs energy. Pyrrolidine-cyclohexane system
, 1986 A data table and a correlation equation are presented for the excess free energy of the Pyrrolidine-cyclohexane system at 298.15 ...
CECCANTI, NORBERTO +2 more
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