Results 131 to 140 of about 55,156 (263)

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

Efficient Synthesis of Cyclopropane-Fused Heterocycles with Bromoethylsulfonium Salt [PDF]

, 2013
Aggarwal, Artamonov, Basavaiah, Boger, Bornholdt, Catalan-Munoz, Chaplinski, de Carne-Carnavalet, Donohoe, Eckert, Feng, Fritz, Fritz, Fritz, Galeazzi, Gensini, Gomi, Gosselck, Gosselck, Greene, Hanessian, Hansch, Huang, Iwabuchi, Jeffery, Kamimura, Kasai, Kim, Kim, Kokotos, Krieter, Krow, Kulinkovich, Lin, Maeda, Mao, McGarrigle, McGarrigle, Meldrum, Miller, Namba, Nelson, Njoroge, Norris, Nunez, Ohno, Renslo, Sabbatini, Sasaki, Sattigeri, Schoepp, Shi, Takahashi, Tverezovsky, Unthank, Unthank, Van Zijl, Wiberg, Wirth, Xie, Xie, Xu, Yamanaka, Yar, Yar, Yar, Zhang   +66 more
core   +3 more sources

Engineering Trace‐Amount Electrolyte Additives for Aqueous Zinc Batteries

Advanced Energy Materials, EarlyView.
Large‐amount additives primarily modify the bulk electrolyte by coordinating with Zn2+ or reshaping the hydrogen‐bond network, thereby altering the overall solution chemistry. In contrast, trace‐amount additives mainly operate at the electrode–electrolyte interface, regulating Zn deposition through electric double‐layer modulation, interfacial ...
Zhaoxin Li, Jinhua Guo, Longjun Chang, Zhenyu Jiang, Shuchang Liu, Chao Wang, Qi Liu, Baohua Li, Zhiqiang Niu, Qing Li   +9 more
wiley   +1 more source

AIEgen Targets the STAT3‒SUCLG2 Axis to Regulate Metabolism for Colorectal Cancer Theranostics

Aggregate, Volume 7, Issue 6, June 2026.
In CRC, TPA‐FB directly binds to STAT3 and blocks its phosphorylation. It reduces SUCLG2 expression, disrupts mitochondrial function and modulates protein succinylation. Our work highlights that targeting oncogenic STAT3, TPA‐FB rewires metabolism and inhibits CRC progression.
Shaomin Zou, Dan Zhong, Song Xiang, Jieping Zhang, Ruijia Zhang, Ziqing Yang, Manqi Meng, Kuiheng Chen, Ling Fang, Bart Ghesquiere, Hai‐Tao Feng, Ben Zhong Tang, Lekun Fang   +12 more
wiley   +1 more source

Electronic Smoking Devices Among University Students: Usage Patterns and Chemical Composition of Inhaled Substances

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT This study investigated the prevalence of electronic smoking device (ESD) use and its associated behavioural and chemical risks among university students in Bahia, Brazil. A cross‐sectional survey was conducted with 355 students from public and private institutions through an online questionnaire between April and May 2023. Among participants,
Eduard F. Valenzuela, Raffael Silva Santos Almeida, Ivana Ferreira Simões, Aline Gonçalves Miranda, Magno Oliveira Ramos, Roberto Rodrigues Bandeira Tosta Maciel, Fernanda Warken Rosa, Aníbal de Freitas Santos Júnior   +7 more
wiley   +1 more source

Copper Joins the Monoelectronic Game: Leveraging the CuI Potential for SET‐, XAT‐, and HAT‐Driven Catalytic Organic Synthesis

ChemCatChem, Volume 18, Issue 11, 15 June 2026.
This review surveys the emerging role of copper(I) catalysis in sustainable synthesis, highlighting its exceptional capacity for monoelectronic processes. By examining the strategies based on electron, halogen, and hydrogen transfer processes (SET, XAT, and HAT, respectively), we outline key reactivity trends, design principles, and the synthetic ...
Antonio Torres‐Calis, Juventino J. García   +1 more
wiley   +1 more source

Iridium‐Catalyzed Linear‐Selective sp3 C−H Alkylation of N‐Methylamides Using Alkenes Enabled by Diphosphite Ligands

Chemistry – A European Journal, Volume 32, Issue 21, 1 June 2026.
An iridium‐catalyzed linear‐selective sp3 C─H alkylation of N‐methylamides with alkenes is described. This method tolerates various N‐methylacetamide derivatives and has a broad alkene scope. Mechanistic studies were also conducted. Internal alkenes can also be used through in situ consecutive alkene isomerization.
Haluhi Takahashi, Takanori Shibata
wiley   +1 more source

Method for Reductive N‐Alkylation of a Secondary Amine With an Aldehyde at Room Temperature Through Utilization of an Imine Reductase

Chemistry–Methods, Volume 6, Issue 6, June 2026.
An organic‐synthetic method for smooth N‐alkylation of a secondary amine with an aldehyde as reagents and glucose as a reducing agent in aqueous medium has been developed, exemplified for the N‐benzylation of 2‐methylpyrrolidine. This transformation proceeds through enzyme catalysis with an imine reductase as a biocatalyst and a glucose dehydrogenase ...
Kateryna Zelenska, Harald Gröger
wiley   +1 more source

Peptide binding at the gasdermin D exosite reveals the structural basis for targeting the site

Acta Crystallographica Section D, Volume 82, Issue 6, Page 615-625, June 2026.
We describe the first structure of gasdermin D with a putative caspase inhibitor peptide analog at 1.6 Å resolution. This work suggests potential druggability of gasdermin D at the exosite by leveraging structure‐based computational design with biochemical characterization.Gasdermin D (GSDMD) has been identified as a critical component of the ...
Renjing Wang, Thu Ho, Aimie Ogawa, Kartika Widjaja, Zachary Brown, Song Yang, Pei Huo, Michael C. Gregory, Aman Singh, Senthil Perumal, Songnian Lin, Alan C. Cheng, Lindsay S. Garrenton, James Mu, Anthony Ogawa, Jill E. Chrencik   +15 more
wiley   +1 more source

Superworm‐Derived Protein Hydrolysate: Functional Properties and Activity Following Enzymatic Processing

Journal of Food Process Engineering, Volume 49, Issue 6, June 2026.
Protein hydrolysate was successfully developed from defatted Zophobas morio flour. The pepsin hydrolysate exhibited superior properties compared to Brauzyn. The hydrolysis process with pepsin achieved a notable hydrolysis degree and yield. Pepsin hydrolysate from Z. morio showed high protein content and solubility.
Cristiani Viegas Brandão Grisi, Lindalva Dantas Peixoto, Paula Izabela Felinto da Costa Cardoso, Priscila Santos Souza, Carolina Lima Cavalcanti Albuquerque, Iris Braz da Silva Araujo, Fábio Anderson Pereira da Silva, Anderson Ferreira Vilela, Maria José de Figueiredo   +8 more
wiley   +1 more source