Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM) [PDF]
, 2003 Pyrrolidine-amide oligonucleotide mimics (POM) 1 were designed to be stereochemically and conformationally similar to natural nucleic acids, but with an oppositely charged, cationic backbone.
Cooper, M.A. +5 more
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Acta Crystallographica Section E, 2014 The title compound, C30H28ClN3O2, features two spiro links, one connecting the piperidine and pyrrolidine rings, and the other connecting the pyrrolidine ring and indole residue. The configuration about the ethene bond is E.
I. S. Ahmed Farag +4 more
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Beyond the Simple Copper(II) Coordination Chemistry with Quinaldinate and Secondary Amines
Molecules, 2020 Copper(II) acetate has reacted in methanol with quinaldinic acid (quinoline-2-carboxylic acid) to form [Cu(quin)2(CH3OH)]∙CH3OH (1) (quin− = an anionic form of the acid) with quinaldinates bound in a bidentate chelating manner.
Barbara Modec, Nina Podjed, Nina Lah
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X=Y–ZH compounds as potential 1,3-dipoles. Part 64: Synthesis of highly substituted conformationally restricted and spiro nitropyrrolidines via Ag(I) catalysed azomethine ylide cycloadditions [PDF]
, 2008 1,3-Dipolar reactions of imines of both acyclic and cyclic α-amino esters with a range of nitroolefins using a combination of AgOAc or Ag2O with NEt3 are described.
Albert +51 more
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1-(Pyrrolidin-1-yl)ethan-1-iminium chloride
IUCrData, 2023 The title compound, C6H13N2+·Cl−, is as an amidinium salt that was isolated as unexpected product from the reaction between acetonitrile, chloroform and pyrrolidine under refluxing conditions.
Rylan Artis +2 more
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Recent Advances in Intramolecular C─N Bond Formation for Pyrrolidine Synthesis. [PDF]
ChemistryOpenThis review highlights synthetic advances (2013–2025) in intramolecular C─N bond formation for constructing the pharmaceutically relevant pyrrolidine core. The review is organized into five methodological clusters: 1) intramolecular alkene/alkyne amination; 2) tandem annulations, which involve C─N bond formation as the key step; 3) nucleophilic ...
Kroņkalne R, Turks M.
europepmc +2 more sources
Sonogashira/N-acyliminium ion aromatic π-cyclisation processes: access to tetra- and pentacyclic lactams [PDF]
, 2008 Application of the Sonogashira reaction of N-alkynylimides with 2-iodophenol or 2-iodo-N-tosylaniline affords 2-(N-alkylimino)-benzofurans and indoles in good yield.
Grigg, R., Sridharan, V., Sykes, D.A.
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One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines
Molecules, 2022 Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts ...
Qiao Song +5 more
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Synthesis and biological evaluation of novel PDMP analogues [PDF]
, 2006 A new series of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide, has been synthesized from D-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward ...
Boldin-Adamsky, Swetlana +5 more
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Pyrrolidine nucleotide analogs with a tunable conformation
Beilstein Journal of Organic Chemistry, 2014 Conformational preferences of the pyrrolidine ring in nucleotide analogs 7–14 were investigated by means of NMR and molecular modeling. The effect of the relative configuration of hydroxy and nucleobase substituents as well as the effect of the ...
Lenka Poštová Slavětínská +2 more
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