Results 11 to 20 of about 13,199 (173)

Glycine-Based [3+2] Cycloaddition for the Synthesis of Pyrrolidine-Containing Polycyclic Compounds

Molecules
The synthesis of pyrrolidine compounds with biological interest is an active research topic. Glycine could be a versatile starting material for making pyrrolidine derivatives.
Tieli Zhou, Xiaofeng Zhang, Desheng Zhan, Wei Zhang   +3 more
doaj   +2 more sources

Enantioselective Construction of Chiral Bispiro[Oxindole-Pyrrolidine-Pyrazolone] Derivatives via Sequential and One-Pot Mannich/Hydroamination Reaction

, 2021
The atom-economic method for the preparation of novel bispirocyclic compounds containing three fused heterocyclic scaffolds privileged in drug discovery was developed by using a chiral amine-squaramide Mannich reaction and Au­(I)-catalyzed hydroamination.
Michal Urban (11773454), Jan Veselý (1843195), Martin Nigríni (11751478), Ivana Císařová (1580947)   +3 more
core   +2 more sources

Pyrrolidine-oxadiazolone conjugate as new organocatalyst for asymmetric aldol condensation

, 2023
A proline-based, chiral bi-functional organocatalyst containing both pyrrolidine and oxadiazolone heterocycle, has been successfully applied for stereoselective aldol reactions.
Chandan K. Mahato (6171422), Subhro Mandal (10297738), Mrinalkanti Kundu (1399477), Animesh Pramanik (1656421)   +3 more
core   +1 more source

The Regiocontrollable Enantioselective Synthesis of Chiral Trifluoromethyl-Containing Spiro-Pyrrolidine-Pyrazolone Compounds via Amino-Regulated 1,3-Proton Migration Reaction

, 2021
An amino-controlled regiodivergent asymmetric synthesis of CF3-containing spiro-pyrrolidine-pyrazolone compounds is described. With alkaloid-derived squaramide as catalyst, the 1,3-dipolar cycloaddition of α,β-unsaturated pyrazolone with diethyl 2-((2,2 ...
Yalan Wang, Wenjin Yan, Yifei Guo (1857688), Fengyun Gao (3856456), Yalan Wang (436178), Mengmeng Sun (3844750), Mengmeng Sun, Yabo Deng, Yifei Guo, Zhenghao Dong (1737685), Zhenghao Dong, Qushuo Chen, Kairong Wang (1555183), Kairong Wang, Fengyun Gao, Yabo Deng (11407859), Yongzhen Li (304449), Yongzhen Li, Qushuo Chen (11407862), Wenjin Yan (1457071)   +19 more
core   +1 more source

Asymmetric Construction of Bispiro[oxindole-pyrrolidine-rhodanine]s via Squaramide-Catalyzed Domino Michael/Mannich [3 + 2] Cycloaddition of Rhodanine Derivatives with N‑(2,2,2-Trifluoroethyl)isatin Ketimines

, 2018
Squaramide-catalyzed asymmetric domino Michael/Mannich [3 + 2] cycloaddition reaction between rhodanine derivatives and N-(2,2,2-trifluoroethyl)­isatin ketimines has been developed to synthesize various bispiro­[oxindole-pyrrolidine-rhodanine]­s with ...
Yong-Xing Song (5492252), Da-Ming Du (1478770)   +1 more
core   +2 more sources

Synthesis of Spiro[indole-3,3′-pyrrolidine]-2′-(thi)ones

, 2022
Spiro[indole-3,3′-pyrrolidine]-2′-ones were synthesized via one-pot chloroformylation-dearomatizing spirocyclization of tryptamine derivatives. Moreover, the “thio” equivalent spiro[indole-3,3′-pyrrolidine]-2′-thiones, for which the synthesis and ...
Seiya Hirao, Norihiko Takeda, Takumi Abe, Motohiro Yasui, Norihiko Takeda (1702105), Seiya Hirao (14307585), Maho Ishikawa (12481019), Tatsuhito Yoshida (14307582), Masafumi Ueda (1883317), Maho Ishikawa, Masafumi Ueda, Haruna Ohbu, Takumi Abe (776526), Haruna Ohbu (14307579), Tatsuhito Yoshida, Motohiro Yasui (5999849)   +15 more
core   +1 more source

A Photocatalytic Method for the Degradation of Pyrrolidine in Water [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2000
A method for the degradation of pyrrolidine in water is described. The method relaies on the photocatalytic degradation of pyrrolidine to CO2 and NH3 by UV irradiation and using titanium dixide semiconductor as a photocatalyst.
Mohammad Hossein Habibi, Majid Mir Mohammad Sadeghi   +1 more
doaj  

Alkaloids of the Genus Datura: Review of a Rich Resource for Natural Product Discovery

Molecules, 2021
The genus Datura (Solanaceae) contains nine species of medicinal plants that have held both curative utility and cultural significance throughout history.
Maris A. Cinelli, A. Daniel Jones
doaj   +1 more source

Enantioselective synthesis of tricyclic amino acid derivatives based on a rigid 4-azatricyclo[5.2.1.02,6]decane skeleton

Beilstein Journal of Organic Chemistry, 2009
An enantioselective route to four tricyclic amino acids and N-tosylamides, composed of a central norbornane framework with a 2-endo,3-endo-annelated pyrrolidine ring and a 5-endo-C1 or -C2 side chain, has been developed. A key intermediate was the chiral,
Matthias Breuning, Tobias Häuser, Christian Mehler, Christian Däschlein, Carsten Strohmann, Andreas Oechsner, Holger Braunschweig   +6 more
doaj   +1 more source

N-Sulfinylpyrrolidine-containing ureas and thioureas as bifunctional organocatalysts

Beilstein Journal of Organic Chemistry, 2021
The synthesis of bifunctional N-sulfinylureas and thioureas with an appended pyrrolidine unit is presented. These organocatalysts were evaluated in Michael additions of aldehydes to nitroalkenes both under solvent-free conditions and in solution.
Viera Poláčková, Dominika Krištofíková, Boglárka Némethová, Renata Górová, Mária Mečiarová, Radovan Šebesta   +5 more
doaj   +1 more source