Results 41 to 50 of about 13,199 (173)

Crystal structure of 3′-(1H-indole-3-carbonyl)-1′-methyl-2-oxo-4′-(4-oxo-4H-chromen-3-yl)spiro[indoline-3,2′-pyrrolidine]-3′-carbonitrile

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C31H22N4O4, the pyrrolidine ring adopts a twist conformation on the N—CH2 bond. The indolin-2-one and the 1H-indole rings are nearly planar (r.m.s.
M. P. Savithri, R. Raja, D. Kathirvelan, B. S. R. Reddy, A. SubbiahPandi   +4 more
doaj   +1 more source

4-Nitrobenzyl 3,4-bis(acetyloxy)-2-(4-methoxyphenyl)pyrrolidine-1-carboxylate: crystal structure, Hirshfeld surface analysis and computational chemistry

Acta Crystallographica Section E: Crystallographic Communications, 2020
The title compound, C23H24N2O9, is a tetra-substituted pyrrolidine derivative with a twisted conformation, with the twist evident in the C—C bond bearing the adjacent acetyloxy substituents.
Sofia Dallasta Pedroso, Ignez Caracelli, Julio Zukerman-Schpector, Monica Soto-Monsalve, Regina H. De Almeida Santos, Carlos Roque D. Correia, Ariel L. Llanes Garcia, Huey Chong Kwong, Edward R. T. Tiekink   +8 more
doaj   +1 more source

The synthesis of pyrrolidinium pyrrolidine-1-carbodithioate (PPC, 3) from pyrrolidine (1) and carbon disulfide (2).

, 2013
The synthesis of pyrrolidinium pyrrolidine-1-carbodithioate (PPC, 3) from pyrrolidine (1) and carbon disulfide (2).
Monika Sharma (421673), Nand Lal (427630), Tara Rawat (427631), Bhavana Kushwaha (427629), Lalit Kumar (232975), Anil K. Dwivedi (427632), Gopal Gupta (427635), Vishnu L. Sharma (427634), Jagdamba P. Maikhuri (427633), Vikas Sharma (179393), Ashish Jain (427627), Vikas Verma (427628), Lokesh Kumar (427626)   +12 more
core   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The treatment of neuropathic pain is one of the urgent unmet medical needs and T-type calcium channels are promising therapeutic targets for neuropathic pain.
Hak Kyun Yang, Woo Seung Son, Keon Seung Lim, Gun Hee Kim, Eun Jeong Lim, Changdev G. Gadhe, Jae Yeol Lee, Kyu-Sung Jeong, Sang Min Lim, Ae Nim Pae   +9 more
doaj   +1 more source

Crystal structure of (−)-(5R,7R,8S,9R,10S)-8-methyl-7-[(5R)-3-methyl-2-oxooxolan-3-en-5-yl]-1-aza-6-oxatricyclo[8.3.0.05,9]tridecan-13-one monohydrate

Acta Crystallographica Section E: Crystallographic Communications, 2018
The title compound, C17H23NO4·H2O, is an epimer of the natural tetracyclic alkaloid isosaxorumamide which consists of a fused 5–7–5 tricyclic core and a dihydrofuranone substituent.
Takeshi Oishi, Makoto Yoritate, Takaaki Sato, Noritaka Chida   +3 more
doaj   +1 more source

"Synthesis of Bicyclic Pyrrolidine Derivatives and their Photoluminescent Properties"

, 2023
A new and convenient synthesis for pyrrolidine derivatives has been developed starting from 3a,4,7,7atetrahydroisobenzofuran-1,3-dione. 3a,4,7,7a-tetrahydroisobenzo furan-1,3-dione was reacted withamines to give N-ethyl and N-phenyl isoindole derivatives.
Nurhan Kishali, Kishalı, Nurhan
core   +1 more source

Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles

Advanced Science, EarlyView.
We report a rhodium‐catalyzed asymmetric [2+1] spirocyclopropanation of methylene azacycles with trifluoromethyl carbenes in situ derived from fluoroalkyl triftosylhydrazones. ABSTRACT Chiral spirocyclopropyl heterocycles have emerged as privileged three‐dimensional structural motifs in medicinal chemistry.
Yuanhao Zhu, Youzhi Xu, Weitao Zhang, Yongyue Ning, Yaojia Jiang, Yongquan Ning, Genping Huang, Jiawei Cheng, Paramasivam Sivaguru, Xihe Bi   +9 more
wiley   +1 more source

Dual Nickel/Photoredox‐Catalyzed Regio‐ and Enantioselective Alkenylation of Epoxides

Advanced Science, EarlyView.
Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Hongyan Lan, Shengzhou Jin, Zhao‐Dong Xu, Guigen Li, Dingyi Wang   +4 more
wiley   +1 more source

Synthesis of pyrrolidine C-nucleosides via Heck reaction [PDF]

, 2001
A novel method for the synthesis of pyrrolidine C-nucleosides has been developed. The key step of the synthesis is the palladium(0)-mediated coupling of a disubstituted N-protected 2-pyrroline and 5-iodouracil. C-Nucleoside 14 and its N-methyl derivative
Häberli, A., Leumann, Christian, Häberli A, Leumann CJ, Adrian Häberli, Christian J. Leumann   +5 more
core   +1 more source