Results 51 to 60 of about 13,199 (173)

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

Crystal structure of 4-methoxy-N-(piperidine-1-carbonothioyl)benzamide

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, C14H18N2O2S, the piperidine ring has a chair conformation. Its mean plane is twisted with respect to the 4-methoxybenzoyl ring, with a dihedral angle of 63.0 (3)°.
Khairi Suhud, Siti Aishah Hasbullah, Musa Ahmad, Lee Yook Heng, Mohammad B. Kassim   +4 more
doaj   +1 more source

Pyrrolidine-5,5-trans-lactams. 1. Synthesis and Incorporation into Inhibitors of Hepatitis C Virus NS3/4A Protease

, 2016
In this, the first of two letters, we outline the use of the pyrrolidine-5,5-trans-lactam template to design small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease.
Paul S. Jones (2730175), David M. Andrews (2074207), Martin J. Slater (2442742), Helene Chaignot (3066306), J. Ed Robinson (2730184), Gail Mills (2685352), Norman M. Gray (3066309), Barry A. Coomber (3066303), S. Lucy Hind (2730193), Seb J. Carey (2730199)   +9 more
core   +1 more source

Breaking the Durability–Power Trade‐Off: Boron‐Directed Faceted O3 Cathodes for High‐Rate Sodium‐Ion Batteries

Advanced Energy Materials, EarlyView.
Boron‐oxide‐assisted particle engineering stabilizes O3‐type layered cathodes for sodium‐ion batteries by mitigating phase transitions and lattice strain. Acting as flux and structural modifier, boron forms submicron hexagonal platelets with (003) facets and expanded Na‐layer spacing, enabling rapid Na⁺ diffusion and mechanical resilience.
Tengfei Song, Alexis Manche, Dongrui Xie, Bowen Liu, Chenglong Wu, Bo Dong, Reda Malakauskaite, Manoj Ovhal, David O. Scanlon, Emma Kendrick   +9 more
wiley   +1 more source

Fluorescence of 8-Acyl-1-Pyrrolidinylnaphthalenes

Photochem
Four 8-acyl-1-pyrrolidinylnaphalenes are prepared where the acyl group is pivaloyl (6), benzoyl (7), benzyloxycarbonyl (8), and ethyloxycarbonyl (9). Crystal structures for 6–8 show that both the carbonyl and pyrrolidinyl groups are nearly perpendicular ...
Angela Liao, Lucas Teuber, Robert Pike, Christopher Abelt   +3 more
doaj   +1 more source

(2RS,3aRS,9aRS)-3a-Methyl-2-phenyl-3,3a,9,9a-tetrahydro-1H-benzo[f]indol-4(2H)-one Hydrobromide

Molbank
(2RS,3aRS,9aRS)-3a-methyl-2-phenyl-3,3a,9,9a-tetrahydro-1H-benzo[f]indol-4(2H)-one hydrobromide was first synthesized via a tandem aza-Cope rearrangement and Mannich reaction from (1RS,2SR)-2-amino-1-(prop-1-en-2-yl)-2,3-dihydro-1H-inden-1-ol, which, in ...
Denis A. Tiunov, Victor A. Tafeenko, Alexander V. Kurkin   +2 more
doaj   +1 more source

Structural, Electric and Dynamic Properties of (Pyrrolidinium)₃[Bi₂I₉] and (Pyrrolidinium)₃[Sb₂I₉]: New Lead-Free, Organic–Inorganic Hybrids with Narrow Band Gaps

Molecules, 2023
Hybrid organic–inorganic iodides based on Bi(III) and Sb(III) provide integrated functionalities through the combination of high dielectric constants, semiconducting properties and ferroic phases.
Magdalena Rowińska, Anna Piecha-Bisiorek, Wojciech Medycki, Piotr Durlak, Ryszard Jakubas, Anna Gagor   +5 more
doaj   +1 more source

Crystal structure of methyl 7-phenyl-6a,7,7a,8,9,10-hexahydro-6H,11aH-thiochromeno[3,4-b]pyrrolizine-6a-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C22H23NO2S, the inner pyrrolidine ring (A) adopts an envelope conformation with the methine C atom opposite the fused C—N bond as the flap.
M. P. Savithri, M. Suresh, R. Raghunathan, R. Raja, A. SubbiahPandi   +4 more
doaj   +1 more source

Microwave-Assisted Synthesis, Structural Characterization and Assessment of the Antibacterial Activity of Some New Aminopyridine, Pyrrolidine, Piperidine and Morpholine Acetamides

Molecules, 2021
A series of new acetamide derivatives 22–28 of primary and secondary amines and para-toluene sulphinate sodium salt have been synthesized under microwave irradiation and assessed in vitro for their antibacterial activity against one Gram-positive and two
Abdulmajeed S. H. Alsamarrai, Saba S. Abdulghani   +1 more
doaj   +1 more source

Pyrrolidine derivatives

[[abstract]]Disclosed are pyrrolidine compounds of formula (I), wherein the variables are as defined in the specification, these pyrrolidine compounds inhibit dipeptidyl peptidase IV and are suitable for treating Type II ...
Jiaang, WT;Chao, YS;Tsai, TY;Hsu, T
core   +3 more sources