Results 21 to 30 of about 33,483 (272)
A mechanochemical approach to access the proline–proline diketopiperazine framework
Beilstein Journal of Organic Chemistry, 2017 Ball milling was exploited to prepare a substituted proline building block by mechanochemical nucleophilic substitution. Subsequently, the mechanocoupling of hindered proline amino acid derivatives was developed to provide proline–proline dipeptides ...
Nicolas Pétry +9 more
doaj +1 more source
Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
Molecules, 2018 (Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these ...
Baptiste Barré +3 more
doaj +1 more source
Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, EarlyView.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources
Molecules, 2010 The aim of this study was to investigate the in vitro cellular activity of novel spiroisoxazoline type compounds against normal and cancer cell lines from lung tissue (Hs888Lu), neuron-phenotypic cells (SH-SY5Y), neuroblastoma (SH-SY5Y), human ...
Nigar Najim +4 more
doaj +1 more source
Crystals, 2020 One-pot synthesis of three enaminones, (E)-1-(4-chlorophenyl)-3-morpholinoprop-2-en-1-one 1, (E)-1-(4-chlorophenyl)-3-(4-methylpiperazin-1-yl)prop-2-en-1-one 2, and (E)-1-(4-chlorophenyl)-3-(pyrrolidin-1-yl)prop-2-en-1-one 3 were achieved.
Assem Barakat +6 more
doaj +1 more source
Mitochondria‐Damaging Self‐Reporting Probe for Cancer Therapy
Angewandte Chemie, EarlyView.We developed a class of self‐reporting cationic chemotherapeutic probes that selectively induce mitochondrial damage and apoptosis in cancer cells. Their unique mitochondria‐to‐nucleus fluorescence migration enables real‐time visualization of the therapeutic process. ABSTRACT Mitochondrial damage induced by chemotherapeutic agents through disruption of
Hai Xu +10 more
wiley +2 more sources
Acta Crystallographica Section E: Crystallographic Communications, 2020 The title compound, C13H19NO8, is based on a tetra-substituted pyrrolidine ring, which has a twisted conformation about the central C—C bond; the Cm—Ca—Ca—Cme torsion angle is 38.26 (15)° [m = methylcarboxylate, a = acetyloxy and me = methylene].
Sofia Dallasta Pedroso +8 more
doaj +1 more source
Angewandte Chemie, EarlyView.A stereoselective functionalization method of cyclic imines under mild organocatalytic conditions was developed. Bifunctional cinchona alkaloid catalysts combined with carefully optimized reaction conditions to suppress background reactivity enabled highly enantio‐ and diastereoselective addition reactions of malonates to cyclic imines.
Frederic Kölblin, Helma Wennemers
wiley +2 more sources
Acta Crystallographica Section E: Crystallographic Communications, 2018 In the title dispiro compound, C32H26ClN3O2, the cyclohexanone ring of the isoquinoline unit has a distorted envelope conformation, with the methylene C atom adjacent to the spiro C atom as the flap.
R. Vishnupriya +5 more
doaj +1 more source
Angewandte Chemie, EarlyView.Enantioselective aminoarylation of ortho‐allyl anilines is achieved under mild conditions. Key to success is the electrostatically‐directed nature of the key aminopalladation step, achieved by using the sulfonated chiral ligand sSPhos on palladium. A detailed study of electronic trends allows tuning of the sulfonamide protecting group to enable good ...
Max Kadarauch +4 more
wiley +2 more sources