Enumeration of saturated and unsaturated substituted N-heterocycles [PDF]
arXiv, 2023 Mathematical and computational approaches in chemistry and biochemistry fill a gap in respect to the analysis of the physicochemical features of compounds and their functionality and provide an overview of known as well as yet unknown, but hypothetically possible structures.
arxiv
Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide [PDF]
, 2010 A new inhibitor, containing a linked proline-piperidine structure, for the enzyme prolyl oligopeptidase (POP) has been synthesised and demonstrated to bind covalently with the enzyme at the active site.
Bohno +41 more
core +1 more source
Sonogashira/N-acyliminium ion aromatic π-cyclisation processes: access to tetra- and pentacyclic lactams [PDF]
, 2008 Application of the Sonogashira reaction of N-alkynylimides with 2-iodophenol or 2-iodo-N-tosylaniline affords 2-(N-alkylimino)-benzofurans and indoles in good yield.
Grigg, R., Sridharan, V., Sykes, D.A.
core +1 more source
Scientific Reports, 2016 The spiro[pyrrolidine-3, 3´-oxindole] moiety is present as a core in number of alkaloids with substantial biological activities. Here in we report design and synthesis of a library of compounds bearing spiro[pyrrolidine-3, 3´-oxindole] motifs that ...
Santanu Hati +7 more
semanticscholar +1 more source
Syn-Ethyl 1-hydroxy-7-methoxy-2,3-dihydro-1H-pyrrolo[3,4-b]quinolone-3-carboxylate HCl Salt
Molbank, 2015 This short note describes a one-step synthesis of the title compound from commercially available starting materials and reports its full spectroscopic characterization data.
Marcus Baumann, Ian R. Baxendale
doaj +1 more source
Synthesis of enantiomeric polyhydroxyalkylpyrrolidines from 1,3-dipolar cycloadducts. Evaluation as inhibitors of a β-galactofuranosidase [PDF]
, 2016 Enantiomeric 2,3,4-tris(hydroxyalkyl)-5-phenylpyrrolidines have been synthesized from the major cycloadducts obtained by the 1,3-dipolar cycloaddition of sugar enones with azomethine ylides derived from natural amino acids.
Oliveira Udry, Guillermo Alejandro +3 more
core +2 more sources
Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
Molecules, 2018 (Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these ...
Baptiste Barré +3 more
doaj +1 more source
Ethyl 3,4-bis(acetyloxy)-2-(4-methoxyphenyl)pyrrolidine-1-carboxylate
IUCrData, 2020 The title pyrrolidine compound, C18H23NO7, is a tetra-substituted species in which the five-membered ring has a twisted conformation with the twist occurring in the C—C bond bearing the adjacent acetyloxy substituents; the Cm—Ca—Ca—Cp torsion angle is ...
Sofia Dallasta Pedroso +7 more
doaj +1 more source
The effects of a pyrrolidine functional group on the magnetic properties of N@C60 [PDF]
, 2006 A new stable pyrrolidine functionalized fullerene derivative, C69H10N2O2, has been synthesized, purified by high performance liquid chromatography, and characterized by MALDI mass spectrometry, ultraviolet-visible spectroscopy, Fourier transform infrared, 1H and 13C nuclear magnetic resonance. The magnetic properties of the analogous endohedral species
arxiv +1 more source
Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121) [PDF]
, 2011 YS-121 [2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid] is the result of target-oriented structural derivatization of pirinixic acid.
Gabler, Matthias +1 more
core +2 more sources