Construction of N-Aryl-Substituted Pyrrolidines by Successive Reductive Amination of Diketones via Transfer Hydrogenation [PDF]
MoleculesN-aryl-substituted pyrrolidines are important moieties widely found in bioactive substances and drugs. Herein, we present a practical reductive amination of diketones with anilines for the synthesis of N-aryl-substituted pyrrolidines in good to excellent
Jianhua Liao +4 more
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Synthesis of a New Chiral Pyrrolidine [PDF]
Molecules, 2010 The synthesis of a new chiral pyrrolidine has been performed using 2,3-O-isopropylidene-D-erythronolactol as a suitable starting material.
Pilar García +7 more
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Rh(II)/Pd(0) Dual Catalysis: Carbenoid N-H Insertion/Allylation Cascade Reaction to Construct Highly Functionalized and Polysubstituted Pyrrolidines [PDF]
MoleculesIn the category of drugs approved by the U.S. FDA, pyrrolidine is the most frequently used core of five-membered nonaromatic heterocycles containing nitrogen.
Maocheng Tang +5 more
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Synthesis of dienes from pyrrolidines using skeletal modification [PDF]
Nature Communications, 2023 Saturated N-heterocyclic pyrrolidines are common in natural products, medicinal compounds and agrochemicals. However, reconstruction of their skeletal structures creating new chemical space is a challenging task, and limited methods exist for this ...
Haitao Qin +4 more
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Regioselective access to polycyclic N-heterocycles via homogeneous copper-catalyzed cascade cyclization of allenynes [PDF]
Communications Chemistry, 2023 Polycyclic N-heterocycles are important structural motifs commonly found in bioactive compounds, however, their selective construction via the cyclization of allenynes remains challenging yet highly desirable.
Kua-Fei Wei +6 more
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Redox-neutral α-functionalization of pyrrolidines: facile access to α-aryl-substituted pyrrolidines. [PDF]
RSC AdvUsing a quinone monoacetal as the oxidant and DABCO as the base, we report the one-step synthesis of α-aryl-substituted pyrrolidines from pyrrolidine. The reaction of pyrrolidine and quinone monoacetal in 2,2,2-trifluoroethanol afforded octahydro-dipyrroloquinoline in high yield.
Tian FX, Liu FF, Wei J, Xiao JX, Qu J.
europepmc +3 more sources
Atroposelective Synthesis of Axially Chiral Naphthylpyrroles by a Catalytic Asymmetric 1,3-Dipolar Cycloaddition/Aromatization Sequence. [PDF]
Org LettA straightforward methodology for the enantioselective preparation of axially chiral 2-naphthylpyrroles has been developed. This protocol is based on a CuI/Fesulphos-catalyzed highly enantioselective 1,3-dipolar cycloaddition of an azomethine ylide ...
Maclean I +6 more
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Molecules, 2021 1,3-Dipolar cycloaddition reactions of 2-substituted 5-R-3-nitropyridines and isomeric 3-R-5-nitropyridines with N-methyl azomethine ylide were studied. The effect of the substituent at positions 2 and 5 of the pyridine ring on the possibility of the [3 ...
Maxim A. Bastrakov +3 more
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Molecules, 2022 The AgOAc-catalysed reaction of 3-nitro-2-phenyl-2H-chromenes with stabilized azomethine ylides generated from the imines based on methyl glycinate and arylaldehydes leads to a mixture of endo and endo’ isomers of the corresponding chromeno[3,4-c ...
Ivan A. Kochnev +6 more
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Acta Crystallographica Section E Structure Reports Online, 2012 In the title compound, C(4)H(5)NO(2), the non-H atoms are nearly coplanar, with a maximum deviation of 0.030 (1) Å. In the crystal, pairs of mol-ecules are linked by N-H⋯O hydrogen bonds into inversion dimers.
Xing Huang, Min Yu, Feng Gao
openaire +3 more sources