ELECTROCHEMICAL REDUCTION OF 2,2,5,5-TETRAMETHYLPYRROLINE DERIVATIVES TO CORRESPONDING PYRROLIDINES
Advanced Engineering Research, 2012 The reduction technique of 2,2,5,5-tetramethylpyrroline compounds to pyrrolidines on sodium amalgam preformed under the electrolysis of sodium hydroxide solution is described.
Irina Y. Zhukova +2 more
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Facile and Green Synthesis of Saturated Cyclic Amines
Molecules, 2017 Single-nitrogen containing saturated cyclic amines are an important part of both natural and synthetic bioactive compounds. A number of methodologies have been developed for the synthesis of aziridines, azetidines, pyrrolidines, piperidines, azepanes and
Arruje Hameed +7 more
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X=Y–ZH compounds as potential 1,3-dipoles. Part 64: Synthesis of highly substituted conformationally restricted and spiro nitropyrrolidines via Ag(I) catalysed azomethine ylide cycloadditions [PDF]
, 2008 1,3-Dipolar reactions of imines of both acyclic and cyclic α-amino esters with a range of nitroolefins using a combination of AgOAc or Ag2O with NEt3 are described.
Albert +51 more
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Enantiodivergent α-Amino C–H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s [PDF]
, 2019 The introduction of fluoroalkyl groups into organic compounds can significantly alter pharmacological characteristics. One enabling but underexplored approach for the installation of fluoroalkyl groups is selective C(sp^3)–H functionalization due to the ...
Arnold, Frances H. +3 more
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Simultaneous Broadband Suppression of Homonuclear and Heteronuclear Couplings in 1H NMR Spectroscopy
ChemPhysChem, Volume 23, Issue 24, December 16, 2022., 2022 Ultra‐high resolution 1H NMR spectra are obtained by simultaneous broadband suppression of both homonuclear and heteronuclear scalar couplings, giving a fully pure shift 1H NMR spectrum containing chemical shift information only. The analysis of a range of fluorine‐ and phosphorus‐containing systems highlights how this method can be used to aid the ...
Coral Mycroft +3 more
wiley +1 more source
A New Class of Substrates for Nucleophilic 5-endo-trig Cyclization, 2-Trifluoromethyl-1-alkenes: Synthesis of Five-Membered Hetero- and Carbocycles That Bear Fluorinated One-Carbon Units [PDF]
, 2008 Disfavored 5-endo-trig cyclizations were achieved in 2-trifluoromethyl-1-alkenes with a nucleophilic nitrogen, oxygen, sulfur, or carbon atom through 1) intramolecular SN2 reaction with loss of a fluoride ion or 2) intramolecular nucleophilic addition to
Ichikawa Junji +5 more
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Angewandte Chemie, EarlyView.Die ersten Wolfram(VI)‐Fluorido‐Komplexe mit N‐heterocyclischen Carbenen (NHCs) und cyclischen (Alkyl)(Amino)carbenen (cAACs) als Liganden wurden synthetisiert und charakterisiert. Die Reduktion der siebenfach koordinierten Komplexe führte zu seltenen, Lewis‐Basen‐stabilisierten oktaedrischen Wolfram(V)‐Fluorido‐Komplexen, einem dinuklearen, Fluorido ...
Melanie Riethmann +7 more
wiley +1 more source
Metal-mediated intramolecular hydroamination and hydro(acy)alkoxylation reactions [PDF]
, 2012 This PhD thesis describes work undertaken to effect asymmetric catalysis in hydroamination and hydro(acy)alkoxylation reactions of allenes. The introductory Chapter provides an overview of recent advances in asymmetric heterofunctionalisation reactions ...
Arbour, Jannine Louise +1 more
core +1 more source
ChemPhotoChem, Volume 6, Issue 12, December 2022., 2022 Photoswitchable cross‐linkers have the ability to connect two residues on a biomolecule, thereby causing large changes in the structure and function of the target upon irradiation. The design, synthesis and purification of cross‐linkers with large end‐to‐end distances remains challenging, especially for applications in chemical biology.
Jana Volarić +3 more
wiley +1 more source
Synthesis of 3-Substituted Pyrrolidines via Palladium-Catalyzed Hydroarylation
iScience, 2018 Summary: Metal-catalyzed reactions have revolutionized synthetic chemistry, allowing access to unprecedented molecular architectures with powerful properties and activities. Nonetheless, some transformations remain sparse in number, or out of reach, even
Joseph B. Sweeney +2 more
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