Results 131 to 140 of about 36,836 (288)

Novel Application of UHPLC–MS, HRMS, and 2D‐NMR for Structural Elucidation of Eletriptan Hydrobromide and Its Novel Degradation Products

Biomedical Chromatography, Volume 40, Issue 2, February 2026.
ABSTRACT A stability‐indicating UHPLC–MS method was developed to investigate the stress degradation behavior of eletriptan hydrobromide under ICH‐recommended acidic, alkaline, neutral, oxidative, thermal, and photolytic conditions. Significant degradation was observed only under acidic and oxidative stress.
Dastagiri Reddy Bhuma, Venkata Kanaka Srivani Maddala, Suresh Salakolasu, Naresh Kumar Katari   +3 more
wiley   +1 more source

Pyrrolidine and its hydrates –in situcrystallization, structure and properties [PDF]

, 2013
Paulina Taraszewska, Lukas Dobrzycki, Roland Boese   +2 more
openalex   +1 more source

18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco, Matthew Tredwell, Peter J. J. A. Buijnsters, Rhys Salter, Véronique Gouverneur   +13 more
wiley   +2 more sources

Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 1. Structure Elucidation of Additional Important Metabolites

Drug Testing and Analysis, Volume 18, Issue 2, Page 245-259, February 2026.
Well‐characterized, chemically synthesized molecules related to LGD‐4033 metabolism were used as analytical standards for the analysis of LGD‐4033 post‐administration urine samples. This approach offered further insights into LGD‐4033 metabolism, providing solid experimental proof for the structure of important previously reported metabolites and ...
Yiannis S. Angelis, Panagiotis Sakellariou, Mario Thevis, Andreas Thomas, Michael Petrou, Emmanuel N. Pitsinos   +5 more
wiley   +1 more source

The enantiospecific synthesis of (+)-monomorine I using a 5-endo-trig cyclisation strategy

Beilstein Journal of Organic Chemistry, 2007
We have developed a general strategy for the synthesis of 2,5-syn disubstituted pyrrolidines that is based on the multi-faceted reactivity of the sulfone moiety and a 5-endo-trig cyclisation.
Malcolm B. Berry, Donald Craig, Philip S. Jones, Gareth J. Rowlands   +3 more
doaj   +1 more source

Thiophenderivate als vielseitige Vorstufen für die Synthese von (Hetero)aromaten und Naturstoffen

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Verborgen, aber leistungsstark: Thiophene und ihre gesättigten Analoga haben sich als vielseitige C4‐Bausteine erwiesen, die sich effektiv in der Naturstoffsynthese sowie beim Aufbau funktionalisierter (Hetero)aromaten einsetzen lassen. Dieser Minireview soll einen Überblick über Strategien zur Anwendung dieser schwefelhaltigen heterozyklischen ...
Anna Keimer, Franz‐Lucas Haut
wiley   +1 more source

One pot synthesis of pyrrolidines type 3,7-diazabicyclo [3.3.0] octane and biological activity [PDF]

, 2008
Pyrrolidines type 2,4-disubstituted (alkyl, aryl or heteroaryl)-6,8-dioxo-3,7-diazabicyclo [3.3.0] octanes (8a-d) were successfully synthesized by an efficient one pot 1,3-dipolar cycloaddition of azomethine ylides (in situ generated from the reaction of
Amornraksa, Kitti, Prachayasittikul, Virapong, Worachartcheewan, Apilak   +2 more
core  

Exploiting the Reactivity of 1,2-Ketoamides: Enantioselective Syn-thesis of Functionalized Pyrrolidines and Pyrrolo-1,4-benzodiaze-pine-2,5-diones

, 2015
International audienceA new strategy for the synthesis of optically active pyrrolo[ 1,4]benzo- diazepine-2,5-diones has been developed. The approach is based on an initial Michael addition of functionalized 1,2-ketoamides on nitroalkenes, with a ...
Acosta, Paola, Becerra, Diana, Bonne, Damien, Constantieux, Thierry, Goudedranche, Sébastien, Quiroga, Jairo, Rodriguez, Jean   +6 more
core   +4 more sources

ChemInform Abstract: An Organocatalytic Direct Mannich—Cyclization Cascade as [3 + 2] Annulation: Asymmetric Synthesis of 2,3‐Substituted Pyrrolidines. [PDF]

, 2012
Indresh Kumar, Nisar A. Mir, Vivek K. Gupta, Rajnikant Rajnikant   +3 more
openalex   +1 more source

Thiophene Derivatives as Versatile Precursors for (Hetero)Arene and Natural Product Synthesis

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
Hidden but Powerful: Thiophenes and their saturated analogues have been demonstrated to be versatile C4‐building blocks that can be rapidly applied to natural product synthesis and the construction of functionalized (hetero)arenes. This minireview aims to provide a concise overview of the strategies and implementations of these sulfur‐containing ...
Anna Keimer, Franz‐Lucas Haut
wiley   +1 more source