Results 11 to 20 of about 36,836 (288)

Construction of N-Aryl-Substituted Pyrrolidines by Successive Reductive Amination of Diketones via Transfer Hydrogenation [PDF]

Molecules
N-aryl-substituted pyrrolidines are important moieties widely found in bioactive substances and drugs. Herein, we present a practical reductive amination of diketones with anilines for the synthesis of N-aryl-substituted pyrrolidines in good to excellent
Jianhua Liao, Jinghui Tong, Liang Liu, Lu Ouyang, Renshi Luo   +4 more
doaj   +2 more sources

Synthesis of a New Chiral Pyrrolidine [PDF]

Molecules, 2010
The synthesis of a new chiral pyrrolidine has been performed using 2,3-O-isopropylidene-D-erythronolactol as a suitable starting material.
Pilar García, Enrique F. Iglesias, Isidro S. Marcos, Narciso M. Garrido, Rosalina F. Moro, Marta G. Núñez, Mari Fe. Flores, David Díez   +7 more
doaj   +3 more sources

Redox-neutral α-functionalization of pyrrolidines: facile access to α-aryl-substituted pyrrolidines. [PDF]

RSC Adv
Using a quinone monoacetal as the oxidant and DABCO as the base, we report the one-step synthesis of α-aryl-substituted pyrrolidines from pyrrolidine. The reaction of pyrrolidine and quinone monoacetal in 2,2,2-trifluoroethanol afforded octahydro-dipyrroloquinoline in high yield.
Tian FX, Liu FF, Wei J, Xiao JX, Qu J.
europepmc   +3 more sources

One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines

Molecules, 2022
Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts ...
Qiao Song, Sheng Wang, Xiangui Lei, Yan Liu, Xin Wen, Zhouyu Wang   +5 more
doaj   +1 more source

Nitropyridines as 2π-Partners in 1,3-Dipolar Cycloadditions with N-Methyl Azomethine Ylide: An Easy Access to Condensed Pyrrolines

Molecules, 2021
1,3-Dipolar cycloaddition reactions of 2-substituted 5-R-3-nitropyridines and isomeric 3-R-5-nitropyridines with N-methyl azomethine ylide were studied. The effect of the substituent at positions 2 and 5 of the pyridine ring on the possibility of the [3 ...
Maxim A. Bastrakov, Alexey K. Fedorenko, Alexey M. Starosotnikov, Alexander Kh. Shakhnes   +3 more
doaj   +1 more source

Different Behavior of 2-Substituted 3-Nitro-2H-chromenes in the Reaction with Stabilized Azomethine Ylides Generated from α-Iminoesters

Molecules, 2022
The AgOAc-catalysed reaction of 3-nitro-2-phenyl-2H-chromenes with stabilized azomethine ylides generated from the imines based on methyl glycinate and arylaldehydes leads to a mixture of endo and endo’ isomers of the corresponding chromeno[3,4-c ...
Ivan A. Kochnev, Alexey Y. Barkov, Nikita S. Simonov, Maria V. Ulitko, Nikolay S. Zimnitskiy, Vladislav Y. Korotaev, Vyacheslav Y. Sosnovskikh   +6 more
doaj   +1 more source

Pyrrolidine-2,5-dione [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C(4)H(5)NO(2), the non-H atoms are nearly coplanar, with a maximum deviation of 0.030 (1) Å. In the crystal, pairs of mol-ecules are linked by N-H⋯O hydrogen bonds into inversion dimers.
Min Yu, Xing Huang, Feng Gao
openaire   +3 more sources

Regioselective access to polycyclic N-heterocycles via homogeneous copper-catalyzed cascade cyclization of allenynes

Communications Chemistry, 2023
Polycyclic N-heterocycles are important structural motifs commonly found in bioactive compounds, however, their selective construction via the cyclization of allenynes remains challenging yet highly desirable.
Kua-Fei Wei, Qing Liu, Guang Ma, Xiao-Lei Jiang, Xiu-Hong Zhu, Guang-Xin Ru, Wen-Bo Shen   +6 more
doaj   +1 more source

[(Pyrrolidin-1-yl)carbothioylsulfanyl]methyl pyrrolidine-1-carbodithioate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
The title compound, C(11)H(18)N(2)S(4), was unexpectedly obtained during studies on the reactivity of the complex tris-(acac-κ(2)O,O')gallium(III) (acac is acetyl-acetonate) with C(4)H(8)NCS(2)H in dichloro-methane. The title compound shows disordered two pyrrolidine rings with major and minor occupancies of 0.546 (4) and 0.454 (4).
Yen-Hsiang Huang, Hsiao-Fen Wang, Wei-Lung Chou, Kuang-Hway Yih, Gene-Hsiang Lee   +4 more
openaire   +3 more sources

Asymmetric Synthesis of Polyfunctionalized Pyrrolidines from Sulfinimine-Derived Pyrrolidine 2-Phosphonates. Synthesis of Pyrrolidine 225C [PDF]

Organic Letters, 2006
[reaction: see text] The Horner-Wadsworth-Emmons reaction of aldehydes with sulfinimine-derived 3-oxo pyrrolidine phosphonates represents a new method for the asymmetric synthesis of ring-functionalized cis-2,5-disubstituted 3-oxo pyrrolidines.
Franklin A, Davis, He, Xu, Yongzhong, Wu, Junyi, Zhang   +3 more
openaire   +2 more sources