Ueber Carbonsäuren des Pyrrolidins [PDF]
Berichte der deutschen chemischen Gesellschaft, 1899 n ...
Willstätter, Richard +1 more
openaire +3 more sources
Asymmetric additions to dienes catalysed by a dithiophosphoric acid. [PDF]
, 2011 Chiral Brønsted acids (proton donors) have been shown to facilitate a broad range of asymmetric chemical transformations under catalytic conditions without requiring additional toxic or expensive metals.
Hamilton, Gregory +4 more
core +2 more sources
Synthesis of Nitrogenated Heterocycles by Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)haloimines [PDF]
, 2013 Highly optically enriched, protected, nitrogenated heterocycles with different ring sizes have been synthesized by a very efficient methodology consisting of the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)haloimines followed by treatment ...
Ahn K. +76 more
core +2 more sources
Ferrocene-derived P,N ligands : synthesis and application in enantioselective catalysis [PDF]
, 2013 Due to their unique steric and electronic properties, air-stability and modular structure, chiral hybrid P,N-ferrocenyl ligands play a prominent role in the field of asymmetric catalysis.
Noël, Timothy, Van der Eycken, Johan
core +1 more source
Intramolecular hydrogen bond activation: Thiourea-organocatalyzed enantioselective 1,3-dipolar cycloaddition of salicylaldehyde-derived azomethine ylides with nitroalkenes [PDF]
, 2018 An organocatalytic strategy for the synthesis of tetrasubstituted pyrrolidines with monoactivated azomethine ylides in high enantiomeric excess and excellent exo/endo selectivity is presented.
Alberto Fraile (1447588) +8 more
core +6 more sources
Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds [PDF]
, 2021 The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by medicinal chemists to obtain compounds for the treatment of human diseases.
Barraja P. +5 more
core +1 more source
Stereoselective Synthesis of Cyclobutanes by Contraction of Pyrrolidines [PDF]
Journal of the American Chemical Society, 2021 Here we report a contractive synthesis of multisubstituted cyclobutanes containing multiple stereocenters from readily accessible pyrrolidines using iodonitrene chemistry. Mediated by a nitrogen extrusion process, the stereospecific synthesis of cyclobutanes involves a radical pathway.
Chunngai Hui +5 more
openaire +4 more sources
Enumeration of saturated and unsaturated substituted N-heterocycles [PDF]
arXiv, 2023 Mathematical and computational approaches in chemistry and biochemistry fill a gap in respect to the analysis of the physicochemical features of compounds and their functionality and provide an overview of known as well as yet unknown, but hypothetically possible structures.
arxiv
Drug Repurposing for COVID-19 via Knowledge Graph Completion [PDF]
, 2020 Objective: To discover candidate drugs to repurpose for COVID-19 using literature-derived knowledge and knowledge graph completion methods. Methods: We propose a novel, integrative, and neural network-based literature-based discovery (LBD) approach to identify drug candidates from both PubMed and COVID-19-focused research literature.
arxiv +1 more source
Highly diastereoselective 1,3-dipolar cycloaddition of nonstabilized azomethine ylides to 3-nitro-2-trihalomethyl-2H-chromenes: Synthesis of 1-benzopyrano[3,4-c]pyrrolidines [PDF]
, 2013 Reactions of 3-nitro-2-trifluoro(trichloro)methyl-2H-chromenes, including 2-unsubstituted derivatives, with N-alkyl-α-amino acids (sarcosine, proline) and paraformaldehyde proceed diastereoselectively to give 1-benzopyrano[3,4-c]pyrrolidines in good ...
Barkov, A. Y. +5 more
core +1 more source