Synthesis of Chromen[4,3-b]pyrrolidines by Intramolecular 1,3-Dipolar Cycloadditions of Azomethine Ylides: An Experimental and Computational Assessment of the Origin of Stereocontrol [PDF]
, 2015 Azomethine ylides, generated from imine-derived O-cinnamyl or O-crotonyl salicylaldeyde and α-amino acids, undergo intramolecular 1,3-dipolar cycloaddition, leading to chromene[4,3-b]pyrrolidines.
Arrieta, Ana +8 more
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Tetraethyl(pyrrolidine-2,2-diyl)bisphosphonate [PDF]
Molecules, 2001 The synthesis of the title compound is already described [1, 2] and we report here the fully optimized procedure.[...]
Olive, Gilles, Jacques, Alain
openaire +3 more sources
Synthesis of 3-Substituted Pyrrolidines via Palladium-Catalyzed Hydroarylation
iScience, 2018 Summary: Metal-catalyzed reactions have revolutionized synthetic chemistry, allowing access to unprecedented molecular architectures with powerful properties and activities. Nonetheless, some transformations remain sparse in number, or out of reach, even
Joseph B. Sweeney +2 more
doaj +1 more source
Regio- and Stereoselective Aminopentadienylation of Carbonyl Compounds [PDF]
, 2014 A simple and robust protocol is detailed for the preparation of enantioenriched α-substituted (1,4-pentadien-3-yl)amine derivatives. The methodology involves the addition of an in situ formed pentadienyl indium reagent to chiral tert-butylsulfinimines ...
Bagdatli, Emine +3 more
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IUCrData, 2016 In the title compound, C34H25N3O4·0.5CH2Cl2, which crystallized as a dichloromethane hemisolvate, the central 1-methylpyrrolidine ring adopts an envelope conformation with the N atom as the flap.
J. M. Joseph +2 more
doaj +1 more source
Molecules, 2020 The reaction of meso-tetrakis(pentafluorophenyl)porpholactone with azomethine ylides and nitrones affords pyrrolidine-fused and isoxazolidine-fused dihydroporpholactones that display, respectively, isobacteriochlorin- and chlorin-type UV–Vis spectra ...
Ana F. R. Cerqueira +5 more
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Buflomedil for intermittent claudication [PDF]
, 2013 Background : Intermittent claudication (IC) is pain caused by chronic occlusive arterial disease, that develops in a limb during exercise and is relieved with rest. Buflomedil is a vasoactive agent used to treat peripheral vascular disease.
De Backer, Tine, Vander Stichele, Robert
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Synthesis of dienes from pyrrolidines using skeletal modification
Nature Communications, 2023 Saturated N-heterocyclic pyrrolidines are common in natural products, medicinal compounds and agrochemicals. However, reconstruction of their skeletal structures creating new chemical space is a challenging task, and limited methods exist for this ...
Haitao Qin +4 more
doaj +1 more source
Effect of Some Synthesized Pyrrolidines in Growth of L. infantum Promastigotes
Tikrit Journal of Pure Science, 2023 In this research, three pyrrolidine compounds (P1-P3) were synthesized and then tested for efficacy against L. infantum promastigotes in vitro. The study included preparation of some chalcones and schiff bases then the condensation of both to get the
Haitham L. Al-Hayali +2 more
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A New Class of Substrates for Nucleophilic 5-endo-trig Cyclization, 2-Trifluoromethyl-1-alkenes: Synthesis of Five-Membered Hetero- and Carbocycles That Bear Fluorinated One-Carbon Units [PDF]
, 2008 Disfavored 5-endo-trig cyclizations were achieved in 2-trifluoromethyl-1-alkenes with a nucleophilic nitrogen, oxygen, sulfur, or carbon atom through 1) intramolecular SN2 reaction with loss of a fluoride ion or 2) intramolecular nucleophilic addition to
Ichikawa Junji +5 more
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