Metabolites from Marine Macroorganisms of the Red Sea Acting as Promoters or Inhibitors of Amylin Aggregation [PDF]
BiomoleculesAmylin is part of the endocrine pancreatic system that contributes to glycemic control, regulating blood glucose levels. However, human amylin has a high tendency to aggregate, forming isolated amylin deposits that are observed in patients with type 2 ...
Mawadda Alghrably +11 more
doaj +5 more sources
Secondary metabolites from the Endophytic fungi Fusarium decemcellulare F25 and their antifungal activities [PDF]
Frontiers in Microbiology, 2023 Seven new compounds, including three isocoumarins (1–3), three pyrrolidinone derivatives (8–10), and one pentaene diacid (15), together with 13 known compounds, were isolated from the rice culture of the endophytic fungus Fusarium decemcellulare F25 ...
Ziwei Song +7 more
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Synthesis of New Optically Active 2-Pyrrolidinones [PDF]
Molecules, 2012 A new class of optically active 2-pyrrolidinones was synthesized, starting from S-pyroglutamic acid, a well known natural chiral synthon. The synthetic design followed led to the insertion of various substituents at positions 1 and 5 of the 2 ...
Thomas Mavromoustakos +2 more
doaj +4 more sources
Co(II) complexes with 2-pyrrolidinone [PDF]
Canadian Journal of Chemistry, 1969 For the known complexes CoL3X2 (X = Cl, Br, and L = 2-pyrrolidinone) a more detailed infrared study was made. Together with the electronic spectra this study indicates dissociation of CoL2X3 into CoL2X2 + L in chloroform and acetone solution. The conductivity measurements and the molecular weight determinations also support dissociation.
O. Bohunovsky, Shailja Jain, R. Rivest
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One-Pot Diastereoselective Synthesis of Pyrrolopiperazine-2,6-diones by a Ugi/Nucleophilic Substitution/N-Acylation Sequence. [PDF]
J Org Chem, 2022 The diastereoselective synthesis of two families of pyrrolopiperazine-2,6-diones is presented. These compounds were prepared by one-pot Ugi/nucleophilic substitution/N-acylation/debenzoylation/(elimination) sequences.
González-Saiz B +5 more
europepmc +3 more sources
Synthesis of (S)-Vasicol and (S)-3-Hydroxy-2-pyrrolidinone
HETEROCYCLES, 2003 Stating from (S)-malic acid, a flexible approach to (S)-3-hydroxy-2-pyrrolidinone and (S)-1-alkyl-3-hydroxy-2-pyrrolidinones was reported. Using this method, the first total syntheses of (-)-vasicol as well as deaminovasicol were accomplished, which allowed the revision and clarification the confusion about the structure of naturally occurring ...
Pei‐Qiang Huang, Xiao Zheng, Hua Wei
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Preliminary studies towards the preparation of reactive 3-pyrrolin-2-ones in conjugate addition reactions for the syntheses of potentially bioactive 2-pyrrolidinones and pyrrolidines [PDF]
, 2007 José C. F. Alves
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Synthesis and structural investigation of some 1,4-disubstituted-2-pyrrolidinones
ARKIVOC, 2005 Kristina Brokaite +2 more
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Lewis Base-Catalysed Enantioselective Radical Conjugate Addition for the Synthesis of Enantioenriched Pyrrolidinones [PDF]
, 2022 We report a catalytic asymmetric protocol for the preparation of chiral pyrrolidinones proceeding via a radical pathway. The chemistry exploits the combination of photoredox catalysis and Lewis base catalysis to realise the first example of asymmetric ...
Ermini E. +3 more
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Transition-Metal-Catalyzed Annulations Involving the Activation of C(sp3)−H Bonds [PDF]
, 2021 The selective functionalization of C(sp3)-H bonds using transitionmetal catalysis is among the more attractive transformations of modern synthetic chemistry.
Font Molíns, Marc +2 more
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