Results 1 to 10 of about 2,994 (192)

Synthesis of New Optically Active 2-Pyrrolidinones [PDF]

Molecules, 2012
A new class of optically active 2-pyrrolidinones was synthesized, starting from S-pyroglutamic acid, a well known natural chiral synthon. The synthetic design followed led to the insertion of various substituents at positions 1 and 5 of the 2 ...
Thomas Mavromoustakos, Eleni Papavassilopoulou, Panagiota Moutevelis-Minakakis   +2 more
doaj   +4 more sources

Metabolites from Marine Macroorganisms of the Red Sea Acting as Promoters or Inhibitors of Amylin Aggregation [PDF]

Biomolecules
Amylin is part of the endocrine pancreatic system that contributes to glycemic control, regulating blood glucose levels. However, human amylin has a high tendency to aggregate, forming isolated amylin deposits that are observed in patients with type 2 ...
Mawadda Alghrably, Mohamed A. Tammam, Aikaterini Koutsaviti, Vassilios Roussis, Xabier Lopez, Giulia Bennici, Abeer Sharfalddin, Hanan Almahasheer, Carlos M. Duarte, Abdul-Hamid Emwas, Efstathia Ioannou, Mariusz Jaremko   +11 more
doaj   +2 more sources

Synthesis and structural investigation of some 1,4-disubstituted-2-pyrrolidinones

ARKIVOC, 2005
Kristina Brokaite, Vytautas Mickevicius, Gema Mikulskiene   +2 more
doaj   +3 more sources

Secondary metabolites from the Endophytic fungi Fusarium decemcellulare F25 and their antifungal activities

Frontiers in Microbiology, 2023
Seven new compounds, including three isocoumarins (1–3), three pyrrolidinone derivatives (8–10), and one pentaene diacid (15), together with 13 known compounds, were isolated from the rice culture of the endophytic fungus Fusarium decemcellulare F25 ...
Ziwei Song, Ziwei Song, Yan Jun Sun, Shuangyu Xu, Gang Li, Chunmao Yuan, Kang Zhou, Kang Zhou   +7 more
doaj   +1 more source

Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase

Molecules, 2021
Ten benzoxazole clubbed 2-pyrrolidinones (11–20) as human monoacylglycerol lipase inhibitors were designed on the criteria fulfilling the structural requirements and on the basis of previously reported inhibitors.
Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Mir Mohammad Shahroz, Hemant Kumar Sharma, Yassine Riadi, Md Quamrul Hassan   +5 more
doaj   +1 more source

Synthesis, Characterization and Bioassay of Novel Substituted 1-(3-(1,3-Thiazol-2-yl)phenyl)-5-oxopyrrolidines

Molecules, 2020
Thiazole derivatives attract the attention of scientists both in the field of organic synthesis and bioactivity research due to their high biological activity.
Birutė Sapijanskaitė-Banevič, Božena Šovkovaja, Rita Vaickelionienė, Jūratė Šiugždaitė, Eglė Mickevičiūtė   +4 more
doaj   +1 more source

β-Enamino Esters in Heterocyclic Synthesis: Synthesis of Pyrazolone and Pyridinone Derivatives

Molecules, 2010
An efficient and convenient synthesis of pyrrolidinones and pyridinones utilizing enamino esters as starting material has been described. The structures of the compounds obtained were confirmed by spectral and elemental analyses.
Abdellatif Mohamed Salaheldin, Mariam Abdullah Al-Sheikh   +1 more
doaj   +1 more source

Ultrasound-promoted synthesis of pyrrolidin-2-ones in aqueous medium

Orbital: The Electronic Journal of Chemistry, 2012
Pyrrolidin-2-ones have received considerable attention due to their activity in CNS as nootropic drugs. In parallel, the search for environmentally sustainable processes have been triggered the planning of actions related to organic synthesis.
Márcia Silvana Freire Franco, Alex Fabiani Claro Flores, Lucas Pizzuti   +2 more
doaj   +1 more source

Four-component reaction of cyclic amines, 2-aminobenzothiazole, aromatic aldehydes and acetylenedicarboxylate

Beilstein Journal of Organic Chemistry, 2013
The four-component reaction of 2-aminobenzothiazole, aromatic aldehydes, acetylenedicarboxylate and piperidine or pyrrolidine in ethanol afforded the functionalized 2-pyrrolidinones containing both benzothiazolyl and piperidinyl (or pyrrolidinyl) units ...
Hong Gao, Jing Sun, Chao-Guo Yan
doaj   +1 more source

Pyrrolidinodiones in Enol-Ugi, Enol-Passerini, and Anomalous Enol-Passerini Condensations

Proceedings, 2019
In continuation of our recent research on the development of novel multicomponent reactions with isocyanides, we have used, for the first time, enols as the acid components in Ugi- and Passerini-type reactions. Thus, electron-poor pyrrolidinodiones react
Ana G. Neo, Carlos F. Marcos
doaj   +1 more source