Results 51 to 60 of about 2,994 (192)

Identification of Additional Cases of Severe Neonatal GABA‐Transaminase Deficiency

open access: yesJIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT GABA‐transaminase (GABA‐T) deficiency is a rare disorder of GABA metabolism characterized by neonatal encephalopathy, epilepsy, hypotonia and intellectual disability. It is caused by biallelic pathogenic variants in the ABAT gene. We report a case of a newborn female born to a G10P5 mother, with abnormal fetal movements and polyhydramnios in ...
Deima Alammary   +8 more
wiley   +1 more source

Interferometric Deflection Analysis of Suspended 2D Polyaramid Thin Films

open access: yesSmall Methods, Volume 10, Issue 1, 10 January 2026.
A visible light interferometry technique is developed to measure the deflection of 2D nanofilms, replacing AFM‐based methods. Using theoretical and semi‐empirical models, multicolor interference patterns from broadband excitation are translated into nanoscale deflection estimates.
Michelle Quien   +6 more
wiley   +1 more source

Not Aging but Calorie Restriction Strongly Affects Protein Oxidation in Heart and Brain Mitochondria

open access: yesAging Cell, Volume 25, Issue 1, January 2026.
Our comprehensive proteomic analysis reveals that calorie restriction (CR), not aging, is the primary driver of mitochondrial protein oxidation, with striking tissue‐specific effects. While CR reduces oxidation in the heart, it exerts a dual and opposing role within the cerebrum. ABSTRACT Aging is an inevitable consequence for all organisms.
Shipan Fan   +7 more
wiley   +1 more source

Catalytic Strategies for Amide‐Based Michael Additions: Advances and Perspectives

open access: yesJournal of Chemistry, Volume 2026, Issue 1, 2026.
The Michael addition is a cornerstone transformation in organic synthesis, enabling efficient C–C and C–heteroatom bond formation. Traditionally, α,β‐unsaturated carbonyl compounds such as enones and esters have dominated as Michael acceptors, whereas α,β‐unsaturated amides remain underutilized due to their strong resonance stabilization and low ...
Muhammad Naufal   +6 more
wiley   +1 more source

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