Results 21 to 30 of about 1,834 (157)

Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein. [PDF]

Sci Rep, 2016
AbstractPyrroloquinoline quinone (PQQ), a redox-active o-quinone, is an important nutrient involved in numerous physiological and biochemical processes in mammals. Despite such beneficial functions, the underlying molecular mechanisms remain to be established.
Akagawa M, Minematsu K, Shibata T, Kondo T, Ishii T, Uchida K.   +5 more
europepmc   +3 more sources

Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection

Acta Neuropathologica Communications, 2023
Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range.
Alessio Canovai, James R. Tribble, Melissa Jöe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte, Pete A. Williams   +7 more
doaj   +1 more source

Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention

Biomolecules, 2021
Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates clinically relevant dysfunctions (e.g., those associated with ischemia, inflammation and ...
Karen R. Jonscher, Winyoo Chowanadisai, Robert B. Rucker   +2 more
doaj   +1 more source

Discovery of a eukaryotic pyrroloquinoline quinone-dependent oxidoreductase belonging to a new auxiliary activity family in the database of carbohydrate-active enzymes. [PDF]

PLoS ONE, 2014
Pyrroloquinoline quinone (PQQ) is a redox cofactor utilized by a number of prokaryotic dehydrogenases. Not all prokaryotic organisms are capable of synthesizing PQQ, even though it plays important roles in the growth and development of many organisms ...
Hirotoshi Matsumura, Kiwamu Umezawa, Kouta Takeda, Naohisa Sugimoto, Takuya Ishida, Masahiro Samejima, Hiroyuki Ohno, Makoto Yoshida, Kiyohiko Igarashi, Nobuhumi Nakamura   +9 more
doaj   +1 more source

PQQ Supplementation and SARS-CoV-2 Spike Protein-Induced Heart Inflammation

Natural Product Communications, 2022
SARS-CoV-2 spike protein-induced heart inflammation may originate from either COVID-19 infection or the administration of COVID-19 mRNA vaccines. As pyrroloquinoline quinone (PQQ) is a scavenger of free radicals, redox cofactor, and antioxidant which ...
Alberto Boretti
doaj   +1 more source

An Efficient UPLC-MS/MS Method for the Determination of Pyrroloquinoline Quinone in Rat Plasma and Its Application to a Toxicokinetic Study

Molecules, 2022
Pyrroloquinoline quinone (PQQ) is a powerful antioxidant coenzyme existing in diet, benefiting growth, development, cognition function, and the repair of damaged organs.
Qingmei Sun, Yawen Hong, Zhaoxu Yang, Peixia He, Chao Chen, Jincheng Wang, Qinjie Weng   +6 more
doaj   +1 more source

Escherichia coli is unable to produce pyrroloquinoline quinone (PQQ) [PDF]

Microbiology, 1997
Many bacteria can synthesize the cofactor pyrroloquinoline quinone (PQQ), a cofactor of several dehydrogenases, including glucose dehydrogenase (GCD). Among the enteric bacteria, Klebsiella pneumoniae has been shown to contain the genes required for PQQ biosynthesis.
Matsushita, K., Arents, J.C., Bader, R., Yamada, M., Adachi, O., Postma, P.W.   +5 more
openaire   +3 more sources

Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression

Frontiers in Molecular Biosciences, 2023
Obesity is a major health concern worldwide, and its prevalence continues to increase in several countries. Pyrroloquinoline quinone (PQQ) is naturally found in some foods and is available as a dietary supplement in its disodium crystal form.
Nur Syafiqah Mohamad Ishak, Kazuto Ikemoto   +1 more
doaj   +1 more source

A Multicenter Trial of an Enhanced Serum Comprised of 13 Plant-Based Adaptogens Targeting Skin Quality in Females Impacted by Hormonal Decline. [PDF]

J Cosmet Dermatol
ABSTRACT Objectives To assess the effectiveness and tolerability of a serum comprised of plant‐based adaptogens (MYS‐REV) for visible improvements in skin changes caused by hormonal fluctuations associated with perimenopause and postmenopause in women. Study Designs A 16‐week open‐label multicenter study evaluated the efficacy and tolerability of twice‐
Draelos ZD, Moradi A, Smathers A.
europepmc   +2 more sources

Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice

Scientific Reports, 2022
We investigated whether the oxidoreductase cofactor pyrroloquinoline quinone (PQQ) prevents noise-induced and age-related hearing loss (NIHL and ARHL) in mice.
Ying Gao, Teru Kamogashira, Chisato Fujimoto, Shinichi Iwasaki, Tatsuya Yamasoba   +4 more
doaj   +1 more source