Results 181 to 190 of about 296,841 (265)

Mitochondria: from powerhouses of cells to hubs in antitumor immunity. [PDF]

Front Immunol
Li X, Shi Y, Zhao Y, Zhu G, Jin L.
europepmc   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation. [PDF]

Angew Chem Int Ed Engl
Dörner S, Rogge K, Trottmann F, Hertweck C, Hoffmeister D.   +4 more
europepmc   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Ultra-low field ¹³C MRI of hyperpolarized pyruvate. [PDF]

Commun Chem
Boele T, McBride SJ, Pike M, Curran E, TomHon P, Braaksma H, Shen S, Koonjoo N, Korenchan DE, Chekmenev E, Theis T, Waddington DEJ, Rosen MS.   +12 more
europepmc   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Robust Rapid Cellular Metabolite Sensing Using Benchtop NMR and SABRE-Hyperpolarized [1-¹³C]Pyruvate. [PDF]

Anal Chem
Gyesi J, TomHon P, Abdurraheem A, Samoilenko A, Scofield S, Oladun C, McBride S, Curran E, Pike M, Kadari K, Welch SD, Lipka S, Balboa S, Fehl C, Sadagurski M, Hövener JB, Theis T, Goodson BM, Chekmenev EY.   +18 more
europepmc   +1 more source

Implantation‐On‐Chip: An AI‐Based Platform for Monitoring the Embryo Trophoblast–Endometrial Stroma Cross Talk With Xenobiotics Interference

Advanced Intelligent Systems, EarlyView.
We present a novel AI‐integrated implantation‐on‐chip platform that enables mimicking and monitoring the maternal–fetal interactions at the early phases of human embryo implantation with high spatiotemporal resolution. The complexity of the trophoblast invasion process was addressed by conducting the analysis at global (rate of invasion) and local ...
Joanna Filippi, Valentina Lacconi, Arianna Mencattini, Micol Massimiani, Dolores Lobresca, Gaia Posanzini, Alessia Riccardi, Paola Casti, Michele D’Orazio, Gianni Antonelli, Giorgia Curci, Luisa Campagnolo, Eugenio Martinelli   +12 more
wiley   +1 more source

Optimized Detection of Left Ventricular Hyperpolarized [1-¹³C]Pyruvate Signal in Human Cardiac Metabolic Imaging. [PDF]

Magn Reson Med
Khashami F, Dimitrov IE, Fuetterer M, Glöggler S, Zhang B, Tan E, Kozerke S, Henning A, Hussain T, Malloy CR, Unni N, Zaha VG, CTOX Trial Investigator(s).   +12 more
europepmc   +1 more source