Results 211 to 220 of about 296,841 (265)
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The International Journal of Biochemistry & Cell Biology, 1998
Pyruvate carboxylase [EC 6.4.1.1] is a member of the family of biotin-dependent carboxylases and is found widely among eukaryotic tissues and in many prokaryotic species. It catalyses the ATP-dependent carboxylation of pyruvate to form oxaloacetate which may be utilised in the synthesis of glucose, fat, some amino acids or their derivatives and several
Wallace, J. +2 more
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Pyruvate carboxylase [EC 6.4.1.1] is a member of the family of biotin-dependent carboxylases and is found widely among eukaryotic tissues and in many prokaryotic species. It catalyses the ATP-dependent carboxylation of pyruvate to form oxaloacetate which may be utilised in the synthesis of glucose, fat, some amino acids or their derivatives and several
Wallace, J. +2 more
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Amperometric sensor for pyruvate with immobilized pyruvate oxidase
Analytica Chimica Acta, 1987Abstract Several procedures for immobilization of pyruvate oxidase by chemical bonding are reported. Attachment to nylon net was unsatisfactory in terms of yield and stability. Polyazetidine, a new commercially available prepolymer and a new nylon membrane with surface carboxyl groups provided good long-term stability, up to 30 days in the case of ...
M. Mascini, MAZZEI, Franco
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Disorders of pyruvate carboxylase and the pyruvate dehydrogenase complex
Journal of Inherited Metabolic Disease, 1996SummaryThe most common defect associated with deficiency of the pyruvate dehydrogenase (PDH) complex occurs in the E1 component, specifically due to mutations in the X‐linked E1α gene. Clinical sequelae of these mutations, which range from severe neonatal lactic acidosis to carbohydrate‐sensitive ataxia, can be different in males and females depending ...
B H, Robinson +3 more
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Pyruvate carboxylase deficiency
Journal of Inherited Metabolic Disease, 1984AbstractThe causes of congenital lactic acidaemia are outlined. Isolated pyruvate carboxylase deficiency is reviewed in detail with a report of a recent case and a discussion of the biochemical consequences. Other causes of defective pyruvate carboxylation are described, particularly the combined carboxylase defects.
K, Bartlett +4 more
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Analytica Chimica Acta, 1980
Abstract Pyruvate oxidase (E.C. 1.2.3.3.) is immobilized by adsorption on a porous acetylcellulose membrane, and combined with an oxygen electrode to provide a sensor for pyruvate (0.1–0.8 mM). The response time is 2 min. Glutamate pyruvate transaminase (0.5–180 × 10 -3 I.U. ml -1 ) is determined by its effect on pyruvate production by the alanine—α-
Fumio Mizutani +4 more
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Abstract Pyruvate oxidase (E.C. 1.2.3.3.) is immobilized by adsorption on a porous acetylcellulose membrane, and combined with an oxygen electrode to provide a sensor for pyruvate (0.1–0.8 mM). The response time is 2 min. Glutamate pyruvate transaminase (0.5–180 × 10 -3 I.U. ml -1 ) is determined by its effect on pyruvate production by the alanine—α-
Fumio Mizutani +4 more
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Current Opinion in Anaesthesiology, 2008
Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate was shown to ameliorate some of the structural and functional changes associated with mesenteric ischemia and reperfusion in rats.Treatment with ethyl pyruvate has been shown to improve survival and ameliorate organ dysfunction in a wide variety of ...
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Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate was shown to ameliorate some of the structural and functional changes associated with mesenteric ischemia and reperfusion in rats.Treatment with ethyl pyruvate has been shown to improve survival and ameliorate organ dysfunction in a wide variety of ...
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Pyruvate carboxylase: Affinity labelling of the pyruvate binding site
Biochemical and Biophysical Research Communications, 1975Abstract The active-site-directed reagent, bromopyruvate has been used to covalently label the pyruvate binding site of pyruvate carboxylase (E.C.6.4.1.1.) isolated from sheep liver. Oxalo-acetate proved to be the most effective reaction component in protecting the enzyme against inactivation; pyruvate was less effective although its efficiency was ...
P J, Hudson, D B, Keech, J C, Wallace
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Effects of pyruvate on pyruvate dehydrogenase kinase of rat heart
Molecular and Cellular Biochemistry, 1995Sensitivity of rat heart pyruvate dehydrogenase kinase (PDHK) to pyruvate inhibition was tested under various conditions using pyruvate dehydrogenase complex (PDC) in mitochondria (mPDC) and in a high speed precipitate of whole tissue homogenates (hPDC).
T C, Carter, H G, Coore
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Pyruvate kinase activators for treatment of pyruvate kinase deficiency
Hematology, 2023Abstract Pyruvate kinase (PK) deficiency is a congenital hemolytic anemia with wide-ranging clinical symptoms and complications associated with significant morbidity and reduced health-related quality of life in both children and adults.
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Pyruvate inhibition of pyruvate dehydrogenase kinase is a physiological variable
Biochemical and Biophysical Research Communications, 1985Pyruvate inhibited pyruvate dehydrogenase kinase activity in mitochondria from adipose tissue, heart, brain and kidney of fed rats. Starvation for 24 h led to increased kinase activity in mitochondria from adipose tissue and heart but not from brain or kidney and to reduction of pyruvate inhibition of the enzyme from adipose tissue, heart and brain ...
D, Lyn, H G, Coore
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