Results 51 to 60 of about 142,625 (300)

Geniposide regulates glucose-stimulated insulin secretion possibly through controlling glucose metabolism in INS-1 cells. [PDF]

PLoS ONE, 2013
Glucose-stimulated insulin secretion (GSIS) is essential to the control of metabolic fuel homeostasis. The impairment of GSIS is a key element of β-cell failure and one of causes of type 2 diabetes mellitus (T2DM).
Jianhui Liu, Lixia Guo, Fei Yin, Yonglan Zhang, Zixuan Liu, Yanwen Wang   +5 more
doaj   +1 more source

Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation. [PDF]

PLoS ONE, 2013
Hepatitis C virus (HCV) is highly dependent on cellular factors for its own propagation. By employing tandem affinity purification method, we identified pyruvate carboxylase (PC) as a cellular partner for NS5A protein. NS5A interacted with PC through the
Seung-Ae Yim, Yun-Sook Lim, Jong-Wook Kim, Soon B Hwang   +3 more
doaj   +1 more source

Phenotypic landscape inference reveals multiple evolutionary paths to C$_4$ photosynthesis [PDF]

, 2013
C$_4$ photosynthesis has independently evolved from the ancestral C$_3$ pathway in at least 60 plant lineages, but, as with other complex traits, how it evolved is unclear.
Abramoff, Adams, Akyildiz, Aubry, Beebe, Brown, Brown, Bruhl, Bustin, Casati, Cheng, Christin, Christin, Christin, Christin, Christin, Devi, Devi, Edwards, Furbank, Gavrilets, Goldstein, Gowik, Griffiths, Hatch, Hattersley, Hattersley, Heckman, Hibberd, Hill, Holaday, Holaday, Holaday, Hylton, Johnson, Kajala, Keeley, Kennedy, Khoshravesh, Kidwell, Koteyeva, Kozmik, Ku, Ku, Ku, Ku, Langdale, Livak, Lobkovsky, McKown, McKown, Mooers, Moore, Muhaidat, Osborne, P’yankov, Rabiner, Rajendrudu, Rathnam, Rathnam, Rawsthorne, Rawsthorne, Revuz, Rosche, Roweis, Sage, Sage, Sage, Santos, Sayre, Slack, Smith, Steiner, Ueno, Ueno, Vicentini, Vogan, Voznesenskaya, Voznesenskaya, Voznesenskaya, Wasserman, Weinreich, Whibley, Williams, Wilson, Wiludda, Wittkopp, Wright, Zhu   +88 more
core   +3 more sources

Structure and substrate selectivity of the 750-kDa α6β6 holoenzyme of geranyl-CoA carboxylase. [PDF]

, 2015
Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudomonas organisms with geranic acid as the sole carbon source. GCC has the same domain organization and shares strong sequence conservation with the related biotin-dependent carboxylases 3 ...
Huang, Christine S, Jurado, Ashley R, Tong, Liang, Zhang, Xing, Zhou, Z Hong   +4 more
core   +2 more sources

Probing the Catalytic Roles of Arg548 and Gln552 in the Carboxyl Transferase Domain of the \u3cem\u3eRhizobium etli\u3c/em\u3e Pyruvate Carboxylase by Site-directed Mutagenesis [PDF]

, 2010
The roles of Arg548 and Gln552 residues in the active site of the carboxyl transferase domain of Rhizobium etli pyruvate carboxylase were investigated using site-directed mutagenesis.
Adina-Zada, Abdussalam, Attwood, Paul V., Byrne, Lindsay, Cleland, W. Wallace, Duangpan, Saowapa, Jitrapakdee, Sarawut, Maurice, Martin St., Wallace, John C., Zeczycki, Tonya N.   +8 more
core   +1 more source

Genome-scale architecture of small molecule regulatory networks and the fundamental trade-off between regulation and enzymatic activity [PDF]

, 2017
Metabolic flux is in part regulated by endogenous small molecules that modulate the catalytic activity of an enzyme, e.g., allosteric inhibition. In contrast to transcriptional regulation of enzymes, technical limitations have hindered the production of ...
Briars, Emma, Christodoulou, Dimitris, Goldford, Joshua E., Noor, Elad, Reznik, Ed, Sauer, Uwe, Segrè, Daniel   +6 more
core   +2 more sources

Pyruvate Carboxylase in Rhodopseudomonas spheroides [PDF]

Journal of General Microbiology, 1969
SUMMARY: Unlike some other photosynthetic bacteria, Rhodopseudomonas spheroides directly carboxylates pyruvate in a reaction catalysed by a pyruvate carboxylase (E.C. 6·4.1·1). A partially purified preparation of the enzyme was acetylCoA-dependent. No phosphoenolpyruvate synthetase or phosphoenolpyruvate carboxylase activity was detected in extracts of
J, Payne, J G, Morris
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1Research in Context

EBioMedicine, 2018
Background: Mitochondrial pyruvate import via mitochondrial pyruvate carrier (MPC) is a central step in hepatic gluconeogenesis. Berberine inhibits hepatic gluconeogenesis, but the mechanism is incompletely understood.
Aiyun Li, Qun Liu, Qiang Li, Baolin Liu, Yang Yang, Ning Zhang   +5 more
doaj   +1 more source

The CreC regulator of Escherichia coli, a new target for metabolic manipulations [PDF]

, 2015
The CreBC (carbon source-responsive) two-component regulation system of Escherichia coli affects a number of functions, including intermediary carbon catabolism.
Cabrera Gomez, José Gregorio, Godoy, Manuel Santiago, Nikel, Pablo Ivan, Pettinari, María Julia   +3 more
core   +1 more source