Results 51 to 60 of about 141,799 (322)
ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria [PDF]
, 2009 Mycolic acids are essential for the survival, virulence and antibiotic resistance of the human pathogen Mycobacterium tuberculosis. Inhibitors of mycolic acid biosynthesis, such as isoniazid and ethionamide, have been used as efficient drugs for the ...
Bazet Lyonnet, Bernardo +7 more
core +2 more sources
Frontiers in Physiology, 2019 It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to glucose homeostasis in mammals. This includes other cells in endocrine
Franz M. Matschinsky, David F. Wilson
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Wild-type C. glutamicum ATCC 13032 is known to possess two enzymes with anaplerotic (C4-directed) carboxylation activity, namely phosphoenolpyruvate carboxylase (PEPCx) and pyruvate carboxylase (PCx). On the other hand, C3-directed decarboxylation can be
Jannick Kappelmann +8 more
doaj +1 more source
Metabolic engineering of fast-growing Vibrio natriegens for efficient pyruvate production
Microbial Cell Factories, 2023 Background Pyruvate is a widely used value-added chemical which also serves as a hub of various metabolic pathways. The fastest-growing bacterium Vibrio natriegens is a promising chassis for synthetic biology applications with high substrate uptake rates.
Fengli Wu +4 more
doaj +1 more source
Stem Cell Research, 2023 Pyruvate carboxylase (PC) deficiency (PCD), due to biallelic PC variants, is a rare inherited metabolic disease, which is characterized by seizures, global developmental delay, as well as lactic acidosis, and elevated plasma pyruvate and alanine levels ...
Jingjing Sun, Pei Lu, Yunlin Shen, Li Ma
doaj +1 more source
The dynamic organization of fungal acetyl-CoA carboxylase [PDF]
, 2016 Acetyl-CoA carboxylases (ACCs) catalyse the committed step in fatty-acid biosynthesis: the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. They are important regulatory hubs for metabolic control and relevant drug targets for the treatment of ...
Hagmann, Anna +4 more
core +1 more source
Nature Communications, 2023 The use of gaseous and air-captured CO_2 for technical biosynthesis is highly desired but challenging due to high energy demands. Here, the authors present an ATP and NAD(P)H-free chemoenzymatic system for glycine, serine, and pyruvate biosynthesis by ...
Jianming Liu +4 more
semanticscholar +1 more source
Genome-scale architecture of small molecule regulatory networks and the fundamental trade-off between regulation and enzymatic activity [PDF]
, 2017 Metabolic flux is in part regulated by endogenous small molecules that modulate the catalytic activity of an enzyme, e.g., allosteric inhibition. In contrast to transcriptional regulation of enzymes, technical limitations have hindered the production of ...
Briars, Emma +6 more
core +2 more sources
Geniposide regulates glucose-stimulated insulin secretion possibly through controlling glucose metabolism in INS-1 cells. [PDF]
PLoS ONE, 2013 Glucose-stimulated insulin secretion (GSIS) is essential to the control of metabolic fuel homeostasis. The impairment of GSIS is a key element of β-cell failure and one of causes of type 2 diabetes mellitus (T2DM).
Jianhui Liu +5 more
doaj +1 more source
Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation. [PDF]
PLoS ONE, 2013 Hepatitis C virus (HCV) is highly dependent on cellular factors for its own propagation. By employing tandem affinity purification method, we identified pyruvate carboxylase (PC) as a cellular partner for NS5A protein. NS5A interacted with PC through the
Seung-Ae Yim +3 more
doaj +1 more source