Results 121 to 130 of about 68,490 (304)

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

Electrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source

Innovative PDK1‐Degrading PROTACs Transform Cancer Aerobic Glycolysis and Induce Immunogenic Cell Death in Breast Cancer

Exploration, EarlyView.
In this study, A04, a compound targeting the degradation of metabolic enzyme PDK1, was developed by PROTAC technology, which significantly inhibited tumor proliferation by disrupting the Warburg effect in cancer cells. In the mouse model, A04 could prolong postoperative survival, and also remodel the immunosuppressive microenvironment, which could ...
Aohua Deng, Renming Fan, Jiakui Gou, Ruoxi Sang, Ruizhuo Lin, Ting Zhao, Junyan Zhuang, Yongrui Hai, Jialin Sun, Gaofei Wei   +9 more
wiley   +1 more source

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk. [PDF]

Cardiovasc Res, 2023
Forteza MJ, Berg M, Edsfeldt A, Sun J, Baumgartner R, Kareinen I, Casagrande FB, Hedin U, Zhang S, Vuckovic I, Dzeja PP, Polyzos KA, Gisterå A, Trauelsen M, Schwartz TW, Dib L, Herrmann J, Monaco C, Matic L, Gonçalves I, Ketelhuth DFJ.   +20 more
europepmc   +1 more source

Selective modification of the pyruvate dehydrogenase kinase isoform profile in skeletal muscle in hyperthyroidism: implications for the regulatory impact of glucose on fatty acid oxidation [PDF]

, 2000
MC Sugden, HS Lall, R. Adron Harris, M J Holness   +3 more
openalex   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2019
Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate.
Tsai-Ying Chen, Yi-Ta Hsieh, Jian-Min Huang, Chung-Ji Liu, Lu-Te Chuang, Pei-Chun Huang, Tz-Yu Kuo, Hao-Yuan Chia, Chia-Yi Chou, Ching-Wen Chang, Yi-Fen Chen, Hsin-Ming Chen, Jeng-Fan Lo, Wan-Chun Li   +13 more
doaj  

Gut Microbiota‐Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High‐Altitude

Exploration, EarlyView.
Long‐term migration to high‐altitude areas can readily result in chronic high‐altitude diseases; however, effective prevention and treatment methods are currently lacking. This study employed a multi‐omics approach, integrating metagenomics and metabolomics, to discover and validate that the decreased abundance of Veillonella rogosae, Streptococcus ...
Yongqiang Zhou, Zhexin Ni, Jingjing Liu, Dezhi Sun, Pan Shen, Xi Chen, Gaofu Li, Zhijie Bai, Yangyi Hu, Ningning Wang, Rui Wang, Lina Guan, Yihao Wang, Xianglin Tang, Yungang Lu, Baokun He, Haitao Lu, Wei Zhou, Yue Gao   +18 more
wiley   +1 more source

All-in-One Pyruvate Dehydrogenase Kinase Inhibitor for Tracking, Targeting, and Enhanced Efficacy. [PDF]

Bioconjug Chem, 2023
Zhang X, Sarkar S, Ashokan A, Surnar B, Kolishetti N, Dhar S.   +5 more
europepmc   +1 more source

Marked Differences between Two Isoforms of Human Pyruvate Dehydrogenase Kinase [PDF]

, 2000
Jason C. Baker, Xiaohua Yan, Tianzhou Peng, Shane A. Kasten, Thomas E. Roche   +4 more
openalex   +1 more source

Corynebacterium glutamicum for Microbial Production of Chitin Oligosaccharides Using Modular Engineering

Food Bioengineering, EarlyView.
Based on metabolic engineering, a chitin oligosaccharide (CHOSs) synthesis metabolic pathway was constructed in Corynebacterium glutamicum, establishing a cell factory for CHOSs synthesis through the selection of chassis cells and key enzymes. Utilizing this framework, multiple strategies were employed to enhance the GlcNAc and UDP‐GlcNAc synthesis ...
Chen Deng, Ruijie Xin, Xingjian Li, Liqiang Fan, Yongjun Qiu, Liming Zhao   +5 more
wiley   +1 more source