Results 151 to 160 of about 168,834 (385)

Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions

PLoS ONE, 2017
Pyruvate dehydrogenase kinase 1 (PDK1), a key enzyme implicated in metabolic reprogramming of tumors, is induced in several tumors including glioblastoma, breast cancer and melanoma. However, the role played by PDK1 is not studied in retinoblastoma (RB).
S. Sradhanjali, Devjyoti Tripathy, S. Rath, R. Mittal, M. Reddy   +4 more
semanticscholar   +1 more source

Affinity‐Based Protein Profiling Reveals IDH2 as a Mitochondrial Target of Cannabinol in Receptor‐Independent Neuroprotection

Chemistry – A European Journal, EarlyView.
A chemical probe CBN‐P based on the neuroprotective cannabinoid cannabinol (CBN) was developed and synthesized. CNB‐P was found to have a similar mechanism of action as the parent compound and was used in click‐CLEM microscopy studies and affinity‐based protein profiling to identify the mitochondrial protein isocitrate dehydrogenase 2 (IDH2) as one ...
Eva Schaller, Stephanie Lamer, Andreas Schlosser, Christian Stigloher, Pamela Maher, Michael Decker   +5 more
wiley   +1 more source

Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply [PDF]

, 2000
Mary C. Sugden, Maria L. LANGDOWN, Robert A. Harris, Mark J. Holness   +3 more
openalex   +2 more sources

The emerging role of Nrf2 in mitochondrial function [PDF]

, 2015
The transcription factor NF-E2 p45-related factor 2 (Nrf2; gene name NFE2L2) allows adaptation and survival under conditions of stress by regulating the gene expression of diverse networks of cytoprotective proteins, including antioxidant, anti ...
Abbas, Abdullah, Agyeman, Albena T. Dinkova-Kostova, Andrey Y. Abramov, Anedda, Aoyama, Armah, Athale, Baird, Baird, Baldelli, Benedict, Brewer, Brose, Burton, Calkins, Cao, Chang, Chen, Chowdhry, Christensen, Clements, Cullinan, Dinkova-Kostova, Dinkova-Kostova, Dobrzyn, Dobrzyn, Doulias, East, Finck, Flier, Galuppo, Gan, Gao, Garcia, Giorgio, Greco, Greco, Guerrero-Beltran, Harvey, Hawkes, Hayashi, Hayes, Higgins, Holmstrom, Hu, Hurd, Im, Innamorato, Itoh, Jazwa, Kaidery, Kensler, Kim, Kim, Kim, Kim, Kitteringham, Kobayashi, Kovac, Lee, Liu, Lopez-Bernardo, Ludtmann, MacLeod, Marcotte, Maruyama, McMahon, Meakin, Miller, Mitsuishi, Moser, Negrette-Guzman, Niso-Santano, Pang, Papaiahgari, Piantadosi, Piantadosi, Rada, Rojo, Rustin, Sakurai, Sasaki, Scarpulla, Scarpulla, Scott, Shen, Singh, Smyrnias, Suh, Suzuki, Tanito, Thimmulappa, Tufi, Uruno, Ushida, Wakabayashi, Wang, Wild, Williamson, Woo, Wu, Wu, Xu, Yang, Yates, Youle, Zhang, Zhang, Zhang, Zhu   +111 more
core   +3 more sources

Effects of seven days’ fasting on physical performance and metabolic adaptation during exercise in humans

Nature Communications
Humans have, throughout history, faced periods of starvation necessitating increased physical effort to gather food. To explore adaptations in muscle function, 13 participants (7 males and 6 females) fasted for seven days. They lost 4.6 ± 0.3 kg lean and
Kristoffer J. Kolnes, Emelie T. F. Nilsen, Steffen Brufladt, Allison M. Meadows, Per B. Jeppesen, Øyvind Skattebo, Egil I. Johansen, Jesper B. Birk, Kurt Højlund, Janne Hingst, Bjørn S. Skålhegg, Rasmus Kjøbsted, Julian L. Griffin, Anders J. Kolnes, Stephen O’Rahilly, Jørgen F. P. Wojtaszewski, Jørgen Jensen   +16 more
doaj   +1 more source

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

Cancer & Metabolism, 2019
Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial.
Lei Yu, Shao Thing Teoh, Elliot Ensink, Martin P. Ogrodzinski, Che Yang, Ana I. Vazquez, Sophia Y. Lunt   +6 more
doaj   +1 more source

Absent pyruvate inhibition of pyruvate dehydrogenase kinase in lactating rat mammary gland following various treatments [PDF]

, 1979
Michael A. Baxter, M. Anwar Goheer, Haldane G. Coore   +2 more
openalex   +1 more source

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source

Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase [PDF]

, 1992
O J Park, Denise Cesar, Dennis J. Faix, Kenneth Wu, C.H.L. Shackleton, Marc K. Hellerstein   +5 more
openalex   +1 more source

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

Electrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source