Results 221 to 230 of about 168,834 (385)

PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

Genes and Diseases
Pyruvate dehydrogenase kinase 1 (PDK1) phosphorylates the pyruvate dehydrogenase complex, which inhibits its activity. Inhibiting pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to ...
Yu Wei, Dian Zhang, He Shi, Husun Qian, Hongling Chen, Qian Zeng, Fangfang Jin, Yan Ye, Zuli Ou, Minkang Guo, Bianqin Guo, Tingmei Chen   +11 more
doaj  

Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities. [PDF]

Int J Mol Sci, 2022
Tiersma JF, Evers B, Bakker BM, Jalving M, de Jong S.   +4 more
europepmc   +1 more source

The Glycolytic Enzymes, Glyceraldehyde-3-phosphate Dehydrogenase, Triose-phosphate Isomerase, and Pyruvate Kinase Are Components of the KATP Channel Macromolecular Complex and Regulate Its Function [PDF]

, 2005
Piyali Dhar-Chowdhury, Maddison D. Harrell, Sandra Y. Han, Danuta Jankowska, Lavanya Parachuru, Alison Morrissey, Shekhar Srivastava, Weixia Liu, Brian Malester, Hidetada Yoshida, William A. Coetzee   +10 more
openalex   +1 more source

Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice

Andrology, EarlyView.
Abstract Background Inhibition of sperm maturation in the epididymis is a promising post‐testicular strategy for short‐acting male contraceptives. It has been shown that ROS1, a receptor tyrosine kinase expressed in the epididymis, is essential for epididymal differentiation, sperm maturation, and male fertility in mice.
Yuki Oyama, Kentaro Shimada, Haruhiko Miyata, Rie Iida‐Norita, Chihiro Emori, Maki Kamoshita, Seiya Oura, Ryohei Katayama, Martin M. Matzuk, Masahito Ikawa   +9 more
wiley   +1 more source

Anti-Metastatic Effect of Pyruvate Dehydrogenase Kinase 4 Inhibition in Bladder Cancer via the ERK, SRC, and JNK Pathways. [PDF]

Int J Mol Sci, 2022
Lee EH, Chung JW, Sung E, Yoon BH, Jeon M, Park S, Chun SY, Lee JN, Kim BS, Kim HT, Kim TH, Choi SH, Yoo ES, Kwon TG, Kang HW, Kim WJ, Yun SJ, Lee S, Ha YS.   +18 more
europepmc   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Experiment K-6-21. Effect of microgravity on 1) metabolic enzymes of type 1 and type 2 muscle fibers and on 2) metabolic enzymes, neutransmitter amino acids, and neurotransmitter associated enzymes in motor and somatosensory cerebral cortex. Part 1: Metabolic enzymes of individual muscle fibers; part 2: metabolic enzymes of hippocampus and spinal cord [PDF]

The individual fibers of any individual muscle vary greatly in enzyme composition, a fact which is obscured when enzyme levels of a whole muscle are measured.
Carter, J., Krasnov, I., Lowry, O., Maggie, M.-Y. Chi, Manchester, J., Mcdougal, D., Jr., Nemeth, Patti M., Norris, Beverly, Pusateri, M.   +8 more
core   +1 more source

Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase

SLAS Discovery
Pyruvate dehydrogenase kinases (PDHKs) are non-canonical serine/threonine kinases that regulate the pyruvate dehydrogenase complex. Given their central role in metabolism, dysregulation of PDHKs has been linked with a broad variety of pathological ...
Mya D. Gough, Matthew B. Robers, Cesear R. Corona, Ranjit K. Mehta, Mukesh K. Nyati, Peter L. Toogood   +5 more
doaj  

Promotive role of eukaryotic translation initiation factor 4A isoform 3 in ovarian cancer cell growth and aerobic glycolysis through the pyruvate dehydrogenase kinase 4 signaling. [PDF]

Kaohsiung J Med Sci, 2023
Bai SS, Yan LW, Liu CH.
europepmc   +1 more source

Recognition of the Inner Lipoyl-Bearing Domain of Dihydrolipoyl Transacetylase and of the Blood Glucose-Lowering Compound AZD7545 by Pyruvate Dehydrogenase Kinase 2 [PDF]

, 2007
Alina Tuganova, Alla Klyuyeva, Kirill M. Popov   +2 more
openalex   +1 more source