Results 231 to 240 of about 68,490 (304)

Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity. [PDF]

Sci Rep, 2020
Jin L, Kim EY, Chung TW, Han CW, Park SY, Han JH, Bae SJ, Lee JR, Kim YW, Jang SB, Ha KT.   +10 more
europepmc   +1 more source

Elevated cortisol concentration in preterm sheep fetuses impacts heart development

Experimental Physiology, EarlyView.
Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi, Stacey L. Holman, Melanie R. Bertossa, Ashley S. Meakin, Vicki L. Clifton, Kent L. Thornburg, I. Caroline McMillen, Michael D. Wiese, Mitchell C. Lock, Janna L. Morrison   +9 more
wiley   +1 more source

Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1. [PDF]

J Clin Med, 2020
Schoonjans CA, Mathieu B, Joudiou N, Zampieri LX, Brusa D, Sonveaux P, Feron O, Gallez B.   +7 more
europepmc   +1 more source

Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes

, 2013
Rongya Tao, Xiwen Xiong, Robert A. Harris, Morris F. White, X. Charlie Dong   +4 more
openalex   +2 more sources

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages. [PDF]

J Mol Cell Biol, 2020
Na YR, Jung D, Song J, Park JW, Hong JJ, Seok SH.   +5 more
europepmc   +1 more source

Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas

, 2013
Mithilesh Kumar Jha, Kyoungho Suk
openalex   +1 more source

A simulation study on the role of mitochondria‐sarcoplasmic reticulum Ca2+ interaction in cardiomyocyte energetics during exercise

The Journal of Physiology, EarlyView.
Abstract figure legend An integrated model of human ventricular myocyte with excitation‐contraction‐energetics coupling was created to systematically analyse the contribution of Ca2+ regulation of mitochondrial enzymes to cardiomyocyte functions during workload transition; i.e. exercise.
Ayako Takeuchi, Satoshi Matsuoka
wiley   +1 more source

Understanding the Role of Pyruvate Dehydrogenase Kinase 3 in Gynecological Cancers

Bairy M, Shaheeda A, Suresh PS, Mascarenhas R, Kabekkodu SP.   +4 more
europepmc   +1 more source