Results 231 to 240 of about 168,834 (385)

Assessment of Fasting Metabolism With Microdialysis Indicates Earlier Lipolysis in Children With VLCADD Than MCADD

Acta Paediatrica, Volume 114, Issue 6, Page 1445-1455, June 2025.
ABSTRACT Aim To investigate fasting metabolism in children with very long‐chain acyl‐CoA dehydrogenase deficiency (VLCADD) and medium‐chain acyl‐CoA dehydrogenase deficiency (MCADD) using microdialysis technique. Methods Twelve patients (7 with VLCADD, 5 with MCADD, mean age 4.9 years, 10/12 diagnosed via newborn screening) were recruited for ...
David Olsson, Charlotte Bieneck Haglind, Maria Halldin, Svetlana Lajic, Anna Nordenström   +4 more
wiley   +1 more source

Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance [PDF]

, 2008
Chun-Wun Lu, Shih‐Chieh Lin, Ko‐Fan Chen, Yen-Yu Lai, Shaw‐Jenq Tsai   +4 more
openalex   +1 more source

Real‐world insights from a cohort of approximately 2000 individuals who were analysed using a freely available next‐generation sequencing anaemia screening programme

British Journal of Haematology, EarlyView.
Data from a large cohort of individuals referred for NGS testing evaluate the utility of next‐generation sequencing in clinical practice for diagnosing hereditary haemolytic anaemias.
Jorune Balciuniene, Saliha Yilmaz, Satheesh Chonat, Rachael F. Grace, Gerald A. Soff, Yaddanapudi Ravindranath, Bertil Glader, Paola Bianchi, Bryan McGee, Archana M. Agarwal, Geetha Puthenveetil   +10 more
wiley   +1 more source

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma. [PDF]

Front Oncol, 2021
Kuo YH, Chan TC, Lai HY, Chen TJ, Wu LC, Hsing CH, Li CF.   +6 more
europepmc   +1 more source

Yeast Pyruvate Dehydrogenase Complex Is Regulated by a Concerted Activity of Two Kinases and Two Phosphatases [PDF]

, 2008
Uta Gey, Cornelia Czupalla, Bernard Hoflack, Gerhard Rödel, Udo Krause‐Buchholz   +4 more
openalex   +1 more source

Long‐term efficacy and safety of mitapivat in non‐transfusion‐dependent α‐ or β‐thalassaemia: An open‐label phase 2 study

British Journal of Haematology, EarlyView.
Mitapivat is an oral activator of pyruvate kinase (PK), the enzyme responsible for the final step in glycolysis, and increases production of adenosine triphosphate (ATP), which may lead to improvements in red blood cell health, ineffective erythropoiesis and haemolysis.
Kevin H. M. Kuo, D. Mark Layton, Ashutosh Lal, Elliott P. Vichinsky, Jayme L. Dahlin, Shihao Shen, Gavrielle M. Price, Keely S. Gilroy, Jeremie H. Estepp, Hanny Al‐Samkari   +9 more
wiley   +1 more source

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

Science Translational Medicine, 2017
E. Michelakis, V. Gurtu, Linda Webster, G. Barnes, G. Watson, L. Howard, J. Cupitt, I. Paterson, Richard B. Thompson, Kelvin Chow, D. O’Regan, Lan Zhao, J. Wharton, D. Kiely, A. Kinnaird, Aristeidis E. Boukouris, Christopher White, Jayan Nagendran, D. Freed, S. Wort, J. S. R. Gibbs, M. Wilkins   +21 more
semanticscholar   +1 more source

Interplay between inflammatory reflex and energetic metabolism in endotoxaemia: A role for haem oxygenase 1?

British Journal of Pharmacology, EarlyView.
Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio, Luiz G. S. Branco, Fernanda Brognara, Patrícia Passaglia, Roberta Foresti, Roberto Motterlini   +5 more
wiley   +1 more source

Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes. [PDF]

J Biol Chem
Atser MG, Wenyonu CD, Rowe EM, Leung CLK, Cen HH, Queathem ED, Liu LT, Moravcova R, Rogalski J, Perrin D, Crawford P, Foster LJ, Alcazar A, Johnson JD.   +13 more
europepmc   +1 more source

Corrigendum to "Deficiency of pyruvate dehydrogenase kinase 4 sensitizes mouse liver to diethylnitrosamine and arsenic toxicity through inducing apoptosis" [Liver Res. 2 (2018) 100-107]. [PDF]

Liver Res, 2023
Choiniere J, Lin MJ, Wang L, Wu J.
europepmc   +1 more source