The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]
Diabetes & Metabolism Journal, 2014 The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC.
In-Kyu Lee
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Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, ameliorates type 2 diabetes via reduced gluconeogenesis [PDF]
Heliyon, 2022 Aims: Pyruvate dehydrogenase (PDH) catalyzes the decarboxylation of pyruvate to acetyl-CoA, which plays a key role in linking cytosolic glycolysis to mitochondria metabolism.
Yuko Katayama +3 more
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Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation [PDF]
Cell Reports, 2023 Summary: Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction.
Allison K. Meyers +17 more
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Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer [PDF]
JNCI: Journal of the National Cancer Institute, 2017 The mitochondrial pyruvate dehydrogenase complex (PDC) irreversibly decarboxylates pyruvate to acetyl coenzyme A, thereby linking glycolysis to the tricarboxylic acid cycle and defining a critical step in cellular bioenergetics. Inhibition of PDC activity by pyruvate dehydrogenase kinase (PDK)-mediated phosphorylation has been associated with the ...
P. Stacpoole
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Serum pyruvate dehydrogenase kinase as a prognostic marker for cholangiocarcinoma
Oncology Letters, 2019 Pyruvate dehydrogenase kinase (PDK) is a Ser/Thr kinase that inactivates mitochondrial pyruvate dehydrogenase and serves a key role in aerobic glycolysis, which is a hallmark of cancer cells. The present study determined the PDK expression in cholangiocarcinoma (CCA) tissues and sera to evaluate their applicability as a biomarker for CCA.
Ongart Somintara +10 more
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Regulation of Pyruvate Dehydrogenase Kinase 4 in the Heart through Degradation by the Lon Protease in Response to Mitochondrial Substrate Availability [PDF]
Journal of Biological Chemistry, 2016 Cardiac metabolic inflexibility is driven by robust up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) and phosphorylation-dependent inhibition of pyruvate dehydrogenase (PDH) within a single day of feeding mice a high fat diet. In the current study,
Clair Crewe +4 more
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Essential role of coenzyme A in pyruvate dehydrogenase kinase activity [PDF]
FEBS Letters, 1982 The rate of phosphorylation and concomitant inactivation of purified pig heart muscle pyruvate dehydrogenase complex by intrinsic kinase (EC 2.7.1.99) is markedly accelerated by the addition of coenzyme A to the incubation medium, showing a half‐maximum effect at 1.8 μM. The pantetheine moiety is the effective part of the coenzyme A molecule.
O.H. Weiland, E.A. Siess
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Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas [PDF]
Brain Tumor Research and Treatment, 2013 Metabolic aberrations in the form of altered flux through key metabolic pathways are the major hallmarks of several life-threatening malignancies including malignant gliomas. These adaptations play an important role in the enhancement of the survival and proliferation of gliomas at the expense of the surrounding normal/healthy tissues.
Mithilesh Kumar Jha, Kyoungho Suk
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Pyruvate dehydrogenase kinase regulates hepatitis C virus replication [PDF]
Scientific Reports, 2016 AbstractDuring replication, hepatitis C virus (HCV) utilizes macromolecules produced by its host cell. This process requires host cellular metabolic reprogramming to favor elevated levels of aerobic glycolysis. Therefore, we evaluated whether pyruvate dehydrogenase kinase (PDK), a mitochondrial enzyme that promotes aerobic glycolysis, can regulate HCV ...
Yu Na Kang +18 more
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Journal of Biological Chemistry, 2016 The dorsal root ganglion (DRG) is a highly vulnerable site in diabetic neuropathy. Under diabetic conditions, the DRG is subjected to tissue ischemia or lower ambient oxygen tension that leads to aberrant metabolic functions.
Md Habibur Rahman +10 more
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