Is it possible for pyruvate kinase to be a non-small cell lung cancer marker?
Family Medicine & Primary Care Review, 2016 Background . Lung cancer is the most common cause of morbidity and mortality among all cancers. The dominant type of lung cancer is non-small cell lung cancer.
Aleksandra Kamińska +2 more
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Complete genome sequence of Syntrophobacter fumaroxidans strain (MPOB(T)). [PDF]
, 2012 Syntrophobacter fumaroxidans strain MPOB(T) is the best-studied species of the genus Syntrophobacter. The species is of interest because of its anaerobic syntrophic lifestyle, its involvement in the conversion of propionate to acetate, H2 and CO2 during ...
Crable, Bryan R +15 more
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Advanced Science, EarlyView.This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng +15 more
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Insights Into the Carboxyltransferase Reaction of Pyruvate Carboxylase From the Structures of Bound Product and Intermediate Analogs [PDF]
, 2013 Pyruvate carboxylase (PC) is a biotin-dependent enzyme that catalyzes the MgATP- and bicarbonate-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in central metabolism.
Lietzan, Adam D., Maurice, Martin St.
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Single‐Cell Metabolic Imaging Reveals Glycogen‐Driven Adaptations in Endothelial Cells
Advanced Science, EarlyView.Single‐cell metabolic imaging of diabetes‐associated endothelial dysfunction by SRS microscopy reveals dynamic glycogen storage and its role in modulating metabolic adaptations under glucose starvation. Abstract Endothelial dysfunction (ED) is a defining feature of diabetes mellitus (DM) and a key contributor to many metabolic and cardiovascular ...
Rahuljeet S. Chadha +13 more
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New insights on the mechanism of the K(+-) independent activity of crenarchaeota pyruvate kinases.
PLoS ONE, 2015 Eukarya pyruvate kinases have glutamate at position 117 (numbered according to the rabbit muscle enzyme), whereas in Bacteria have either glutamate or lysine and in Archaea have other residues.
Gustavo De la Vega-Ruíz +7 more
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Advanced Science, EarlyView.The StERF10‐StGSH1 module coordinates glutathione (GSH) biosynthesis under low‐phosphorus stress. The low‐phosphate‐induced AP2/ERF transcription factor StERF10 directly activates the transcription of StGSH1 and enhances GSH accumulation. Consequently, GSH scavenges reactive oxygen species and provides sulfur for sulfolipid synthesis, facilitating the ...
Xiaocheng Tian +9 more
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Metabolic responses to pyruvate kinase deletion in lysine producing
Microbial Cell Factories, 2008 Background Pyruvate kinase is an important element in flux control of the intermediate metabolism. It catalyzes the irreversible conversion of phosphoenolpyruvate into pyruvate and is under allosteric control.
Wittmann Christoph +2 more
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Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas [PDF]
, 2013 Mithilesh Kumar Jha, Kyoungho Suk
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Prognostic significance of pyruvate kinase M2 expression in esophageal squamous cell carcinoma and its meta-analysis [PDF]
, 2021 Qiqi Zhang +7 more
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