Results 111 to 120 of about 234,539 (335)
Is it possible for pyruvate kinase to be a non-small cell lung cancer marker?
Family Medicine & Primary Care Review, 2016 Background . Lung cancer is the most common cause of morbidity and mortality among all cancers. The dominant type of lung cancer is non-small cell lung cancer.
Aleksandra Kamińska +2 more
doaj +1 more source
Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats [PDF]
, 2003 Recent experimental evidences indicate that pyruvate, the final metabolite of glycolysis, has a remarkable protective effect against different types of brain injury.
Candelario-Jalil, Eduardo +3 more
core
Advanced Science, EarlyView.Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin +14 more
wiley +1 more source
Complete genome sequence of Syntrophobacter fumaroxidans strain (MPOB(T)). [PDF]
, 2012 Syntrophobacter fumaroxidans strain MPOB(T) is the best-studied species of the genus Syntrophobacter. The species is of interest because of its anaerobic syntrophic lifestyle, its involvement in the conversion of propionate to acetate, H2 and CO2 during ...
Crable, Bryan R +15 more
core +2 more sources
Advanced Science, EarlyView.Physiological pH transitions modulate protein corona dynamics on nanoparticles, altering their cellular uptake and inflammatory responses. Acidic pHs enhance protein adsorption, induce structural changes, and promote cellular uptake. Simultaneously, inflammatory responses are reduced due to altered protein composition, including decreased ...
Yuting Ge +7 more
wiley +1 more source
Metabolic responses to pyruvate kinase deletion in lysine producing
Microbial Cell Factories, 2008 Background Pyruvate kinase is an important element in flux control of the intermediate metabolism. It catalyzes the irreversible conversion of phosphoenolpyruvate into pyruvate and is under allosteric control.
Wittmann Christoph +2 more
doaj +1 more source
Insights Into the Carboxyltransferase Reaction of Pyruvate Carboxylase From the Structures of Bound Product and Intermediate Analogs [PDF]
, 2013 Pyruvate carboxylase (PC) is a biotin-dependent enzyme that catalyzes the MgATP- and bicarbonate-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in central metabolism.
Lietzan, Adam D., Maurice, Martin St.
core +2 more sources
Advanced Science, EarlyView.FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou +8 more
wiley +1 more source
New insights on the mechanism of the K(+-) independent activity of crenarchaeota pyruvate kinases.
PLoS ONE, 2015 Eukarya pyruvate kinases have glutamate at position 117 (numbered according to the rabbit muscle enzyme), whereas in Bacteria have either glutamate or lysine and in Archaea have other residues.
Gustavo De la Vega-Ruíz +7 more
doaj +1 more source
Anchored phosphatases modulate glucose homeostasis. [PDF]
, 2012 Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways.
Cirulli, Vincenzo +12 more
core +1 more source