Results 161 to 170 of about 240,985 (333)

Role of M2 isoform of pyruvate kinase in diabetic retinopathy

, 2022
Yajing Tian, Xin Cao, Chengwei Duan, Xiaole Wang, Ling-yan Hua, Yu Song   +5 more
openalex   +2 more sources

Epidermal Cell Dynamics Regulates Rice Lamina Joint Morphogenesis and Leaf Angle Formation through OsZHD1 and OsZHD2 Regulation

Advanced Science, EarlyView.
The lamina joint determines leaf angle and plant architecture. Xu et al. establish a live‐imaging system for the rice lamina joint and reveal that asymmetric epidermal cell elongation and division between the lateral and medial edges drive leaf angle formation.
Yiru Xu, Heng Zhou, Xiaojiang Wu, Wuyu Cui, Shouling Xu, Xi He, Dan Xiang, Ming Zhou, Xiuqin Rao, Lilan Hong   +9 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Biogenesis of Organelles and Membrane Proteins. [PDF]

, 1988
Harmey, Matthew A., Neupert, Walter, Nicholson, Donald W., Stuart, Rosemary A.   +3 more
core   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Pyruvate Kinase M2 Expression: A Potential Metabolic Biomarker to Differentiate Endometrial Precancer and Cancer that is Associated with Poor Outcomes in Endometrial Carcinoma [PDF]

, 2019
Yu-Ju Lai, Yu‐Ching Chou, Yi‐Jia Lin, Mu-Hsien Yu, Yu‐Che Ou, Po-Wei Chu, Chia‐Chun Wu, Yu-Chi Wang, Tai‐Kuang Chao   +8 more
openalex   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Peer Review #1 of "Upregulated expression of pyruvate kinase M2 mRNA predicts poor prognosis in lung adenocarcinoma (v0.2)"

, 2020
Guiping Wang, Yingying Zhong, Jiecong Liang, Zhibin Li, Yun Ye, Yingying †, Zhong, D Beer, S Kardia, C Huang, T Giordano, A Levin, D Misek, L Lin, G Chen, T Gharib, D Thomas, M Lizyness, R Kuick, S Hayasaka, J Taylor, M Iannettoni, M Orringer, S Hanash, L Cai, H Bai, J Duan, Z Wang, S Gao, D Wang, S Wang, J Jiang, J Han, Y Tian, X Zhang, H Ye, M Li, B Huang, J He, Wang, D Chandrashekar, B Bashel, Sah Balasubramanya, C Creighton, I Ponce-Rodriguez, B Chakravarthi, S Varambally, B Chu, J Wang, Y Wang, Yang, T Dayton, T Jacks, Vander Heiden, M, S Desai, M Ding, B Wang, Z Lu, Q Zhao, K Shaw, W Yung, J Weinstein, M Tan, J Yao, C Guo, Q Zhu, F Tou, X Wen, Y Kuang, H Hu, B Gyorffy, P Surowiak, J Budczies, Lanczky, J Hou, J Aerts, B Hamer, W Van Ijcken, M Bakker, P Riegman, C Van Der Leest, P Van Der Spek, J Foekens, H Hoogsteden, F Grosveld, S Philipsen, W Huang, S Hsu, H Huang, Y Sun, C Chou, S Weng, H Huang, C Kobierzycki, B Pula, B Werynska, A Piotrowska, B Muszczynska-Bernhard, P Dziegiel   +99 more
openalex   +2 more sources

A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats [PDF]

, 2023
Rosa J.W. Li, Jennifer F.M. Chiu, Kyla Bruce, Song‐Yang Zhang, Daniel R. Barros, Jessica T.Y. Yue, Tony K.T. Lam   +6 more
openalex   +1 more source

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, EarlyView.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source