Results 191 to 200 of about 128,438 (311)

The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the Heart Failure Association of the ESC

European Journal of Heart Failure, EarlyView.
Abstract A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation/immune activation in HF may represent an attempt to restore tissue homeostasis in the failing heart ...
Gabriele Fragasso, Davide Stolfo, Markus S. Anker, Antoni Bayes‐Genis, Ovidiu Chioncel, Stephane Heymans, Pardeep S. Jhund, Basil S. Lewis, Gary D. Lopaschuk, Lars H. Lund, Arantxa Gonzalez, Matteo Pagnesi, Gabriele Giacomo Schiattarella, Carlo Gabriele Tocchetti, Peter van der Meer, Sophie Van Linthout, Sven Wassmann, B. Daan Westenbrink, Marco Metra, Giuseppe M.C. Rosano, Gianluigi Savarese   +20 more
wiley   +1 more source

Non-metabolic enzyme function of pyruvate kinase M2 in breast cancer. [PDF]

Front Oncol
Jemal M, Getinet M, Amare GA, Tegegne BA, Baylie T, Mengistu EF, Osman EE, Chura Waritu N, Adugna A.   +8 more
europepmc   +1 more source

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

Electrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source

Pyruvate kinase M2 modulates mitochondrial dynamics and EMT in alveolar epithelial cells during sepsis-associated pulmonary fibrosis. [PDF]

J Transl Med
Feng J, Huang X, Peng Y, Yang W, Yang X, Tang R, Xu Q, Gao Y, He Z, Xing S, Mei S.   +10 more
europepmc   +1 more source

Evidence for a postsynthetic proteolytic transformation of human erythrocyte pyruvate kinase into L‐type enzyme [PDF]

, 1977
Joëlle Marie, Hervé Garreau, Axel Kahn
openalex   +1 more source

Innovative PDK1‐Degrading PROTACs Transform Cancer Aerobic Glycolysis and Induce Immunogenic Cell Death in Breast Cancer

Exploration, EarlyView.
In this study, A04, a compound targeting the degradation of metabolic enzyme PDK1, was developed by PROTAC technology, which significantly inhibited tumor proliferation by disrupting the Warburg effect in cancer cells. In the mouse model, A04 could prolong postoperative survival, and also remodel the immunosuppressive microenvironment, which could ...
Aohua Deng, Renming Fan, Jiakui Gou, Ruoxi Sang, Ruizhuo Lin, Ting Zhao, Junyan Zhuang, Yongrui Hai, Jialin Sun, Gaofei Wei   +9 more
wiley   +1 more source

Red Cell Pyruvate Kinase Deficiency With Hypertriglyceridemia: A Case Report. [PDF]

Cureus
Hinge DV, Muranjan M, Taksande A, Hampe P.   +3 more
europepmc   +1 more source

Activation of liver pyruvate kinase by fructose‐1‐phosphate [PDF]

, 1970
L. V. Eggleston, H. F. Woods
openalex   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

How We Treat Hemolytic Anemia Due to Pyruvate Kinase Deficiency. [PDF]

Hematol Rep
Tama-Shekan S, Moreno V, Saba L, Chaulagain CP.   +3 more
europepmc   +1 more source