Results 271 to 280 of about 234,539 (335)

Modulation of the phosphorylation state of rat liver pyruvate kinase by allosteric effectors and insulin.

, 1979
T.H. Claus, M. Raafat El‐Maghrabi, S.J. Pilkis   +2 more
openalex   +1 more source

The mechanisms in glucose metabolism of aging hippocampus

Ibrain, EarlyView.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
wiley   +1 more source

Podocyte SIRPα reduction in diabetic nephropathy aggravates podocyte injury by promoting pyruvate kinase M2 nuclear translocation. [PDF]

Redox Biol
Chen Y, Zhang M, Jia R, Qian B, Jing C, Zeng C, Zhu D, Liu Z, Zen K, Li L.   +9 more
europepmc   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, EarlyView.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

Response to Mitapivat: A Quinolone Sulfonamide to Manage Hemolytic Anemia in Adults With Pyruvate Kinase Deficiency. [PDF]

Am J Ther
Boscoe A, McCracken R, Marathe P, Osman K.   +3 more
europepmc   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, EarlyView.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

The Efficacy of Mitapivat in Case of Transfusion Dependence Linked to Beta Thalassemia Trait Associated with Pyruvate Kinase Deficiency. [PDF]

J Cell Mol Med
Fatigati C, Costantini S, Spasiano A, Ziello B, Gambale A, Ricchi P.   +5 more
europepmc   +1 more source

New trend in molecular diagnostics: Insights from the tumor microenvironment

Interdisciplinary Medicine, EarlyView.
The graphical abstract outline the key elements in TME‐based molecular diagnostics, including biomarker exploration, diagnostic methods, and diagnostic models. Source: Created with BioRender.com. Abstract Molecular diagnosis has revolutionized cancer precision medicine.
Baiyuan Fan, Jiahui Zhang, Chong Li, Xu Zhang   +3 more
wiley   +1 more source

Flawed Value Assessment of Mitapivat to Manage Hemolytic Anemia in Adults With Pyruvate Kinase Deficiency. [PDF]

Am J Ther
Boscoe A.
europepmc   +1 more source