Results 271 to 280 of about 128,438 (311)
Some of the next articles are maybe not open access.
The Regulation of Pyruvate Kinase
1971Publisher Summary This chapter discusses the molecular and kinetic properties, and the physiological significance of pyruvate kinase. From a thermodynamic consideration, these enzymes are especially suited for a control of glycolysis, because they catalyze unidirectional steps driving the metabolic flux into one direction.
Werner Seubert, Wilhelm Schoner
openaire +2 more sources
Turnover of liver pyruvate kinase
Archives of Biochemistry and Biophysics, 1980Abstract The relative rates of synthesis and degradation for liver pyruvate kinase have been determined in rats fed standard lab chow, fasted, and refed a high-carbohydrate-low-protein diet. Relative rates of synthesis and apparent rates of degradation were determined by pulse-labeling the enzyme in vivo with l -[4,5- 3 H]leucine and by measuring ...
G. Larry Cottam, Christos Cladaras
openaire +3 more sources
Insulin: Inducer of Pyruvate Kinase
Science, 1965The hepatic pyruvate kinase activity markedly decreased when rats were made diabetic by alloxan injection. Insulin treatment induced new synthesis of pyruvate kinase which was prevented by injection of ethionine and actinomycin D. The evidence indicated that the increased pyruvate kinase activity induced by insulin entails at a certain stage a ...
George Weber +2 more
openaire +3 more sources
Pyruvate kinase of Brevibacterium liquefaciens
Archives of Biochemistry and Biophysics, 1970Abstract Pyruvate kinase was purified 270-fold from an extract of Brevibacterium liquefaciens and its regulatory properties were examined. The purified enzyme existed as an almost inactive form. Preincubation with ATP, NaCl, or with KCl caused marked activation of the enzyme, although these compounds were inhibitory if added during the reaction.
openaire +3 more sources
Effects of pyruvate on pyruvate dehydrogenase kinase of rat heart
Molecular and Cellular Biochemistry, 1995Sensitivity of rat heart pyruvate dehydrogenase kinase (PDHK) to pyruvate inhibition was tested under various conditions using pyruvate dehydrogenase complex (PDC) in mitochondria (mPDC) and in a high speed precipitate of whole tissue homogenates (hPDC).
Haldane G. Coore, Tonia C. Carter
openaire +3 more sources
1987
Publisher Summary The chapter discusses the regulatory phosphorylation of pyruvate kinase type L by cAMP-dependent protein kinase. It also briefly discusses the role of phosphorylation of liver pyruvate kinase in the regulation of glycolysis and gluconeogenesis.
Lorentz Engström +3 more
openaire +2 more sources
Publisher Summary The chapter discusses the regulatory phosphorylation of pyruvate kinase type L by cAMP-dependent protein kinase. It also briefly discusses the role of phosphorylation of liver pyruvate kinase in the regulation of glycolysis and gluconeogenesis.
Lorentz Engström +3 more
openaire +2 more sources
Pyruvate Kinase Deficiency [PDF]
, 1978 Hereditary nonspherocytic hemolytic anemia is a relatively recently recognized entity. It was first discussed in detail by Dacie et al, in 1953,1 and by 1960 over 60 cases had been reported.2 Motulsky et al.3 noted increased 2,3-DPG levels in several patients with hereditary nonspherocytic hemolytic anemia.
openaire +1 more source
1973
Publisher Summary This chapter describes pyruvate kinase. The enzyme has a number of attributes that make it of particular interest to various investigators. It was the first and perhaps the most clearly apparent example of an enzyme with an absolute requirement for a monovalent cation for its catalytic activity.
openaire +2 more sources
Publisher Summary This chapter describes pyruvate kinase. The enzyme has a number of attributes that make it of particular interest to various investigators. It was the first and perhaps the most clearly apparent example of an enzyme with an absolute requirement for a monovalent cation for its catalytic activity.
openaire +2 more sources
The inhibition of pyruvate kinase by ATP
Biochemical and Biophysical Research Communications, 1968Abstract The inhibition of pyruvate kinase by ATP was investigated under various conditions. It was concluded that the inhibition reported by previous workers was attributable to the magnesium complexing properties of ATP and it was shown that the inhibition was abolished completely when sufficient magnesium was added.
openaire +2 more sources
Pyruvate Kinase in Human Erythrocytes
Scandinavian Journal of Haematology, 1969The importance of efficient separation of erythrocytes from leucocytes when studying haemolysates is shown experimentally, pyruvate kinase determination given as an example. The use of the spiral centrifuge is recommended.
openaire +3 more sources