Results 271 to 280 of about 216,078 (374)

Flawed Value Assessment of Mitapivat to Manage Hemolytic Anemia in Adults With Pyruvate Kinase Deficiency. [PDF]

Am J Ther
Boscoe A.
europepmc   +1 more source

PGC‐1α Activation by Polyphenols: A Pathway to Thermogenesis

Molecular Nutrition &Food Research, EarlyView.
Polyphenols, derived from dietary sources such as berries, undergo digestion and interact with gut microbiota, leading to their metabolization in the liver. This process influences bile acid composition, which in turn activates PGC1α, a key regulator of mitochondrial biogenesis and thermogenesis.
Nicholas Vannuchi, Luciana Pisani
wiley   +1 more source

Pyruvate Kinase M2-Responsive Release of Paclitaxel and Indoleamine 2,3-Dioxygenase Inhibitor for Immuno-Chemotherapy of Nonsmall Cell Lung Cancer. [PDF]

Adv Sci (Weinh)
Wu H, Sun X, Li K, Li J, Jiang H, Yan D, Lin Y, Ding Y, Lu Y, Zhu X, Chen X, Li X, Liang G, Xu H.   +13 more
europepmc   +1 more source

Hemolytic anemia due to pyruvate kinase deficiency coexistent with the alpha thalassemia trait and chronic myeloid leukemia. [PDF]

Hematol Transfus Cell Ther
Shrestha N, Khurana H, Verghese R, Mishra Y.   +3 more
europepmc   +1 more source

Activation of Yeast Pyruvate Kinase by Natural and Artificial Cryoprotectants

, 1971
Mary J. Ruwart, Clarence H. Suelter
openalex   +1 more source

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, EarlyView.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

Beyond adenosine triphosphate: unveiling the pleiotropic effects of pyruvate kinase activation in sickle cell anemia. [PDF]

Haematologica
Glenthøj A.
europepmc   +1 more source

Arrangement and conformations of substrates at the active site of pyruvate kinase from model building studies based on magnetic resonance data.

, 1976
Albert S. Mildvan, D L Sloan, Chien‐Hung Fung, Ravindra Kumar Gupta, Eugene Melamud   +4 more
openalex   +1 more source

Fecal Metaproteomics as a Tool to Monitor Functional Modifications Induced in the Gut Microbiota by Ketogenic Diet: A Case Study

PROTEOMICS, EarlyView.
ABSTRACT Metaproteomics is a valuable approach to characterize the biological functions involved in the gut microbiota (GM) response to dietary interventions. Ketogenic diets (KDs) are very effective in controlling seizure severity and frequency in drug‐resistant epilepsy (DRE) and in the weight loss management in obese/overweight individuals.
Alessandro Tanca, Simona Masia, Piero Giustacchini, Sergio Uzzau   +3 more
wiley   +1 more source

Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2. [PDF]

Nat Commun
Wang RH, Chen PR, Chen YT, Chen YC, Chu YH, Chien CC, Chien PC, Lo SY, Wang ZL, Tsou MC, Chen SY, Chiu GS, Chen WL, Wu YH, Wang LH, Wang WC, Lin SY, Kung HJ, Wang LH, Cheng HC, Lin KT.   +20 more
europepmc   +1 more source