Results 271 to 280 of about 237,828 (335)

Proteomics of Prostate Cancer Tissue Small Extracellular Vesicles Reveal Alteration of Metabolism

PROTEOMICS, EarlyView.
ABSTRACT Prostate cancer (PCa) is a leading male malignancy worldwide, with metabolic reprogramming being a critical hallmark of its progression. Extracellular vesicles (EVs) derived from tissues directly reflect the tumor microenvironment, offering unique insights into cancer pathophysiology that are unattainable through cell line or biofluid‐derived ...
Lijuan Yu, Ting Ding, Roger Olofsson Bagge, Lei Zheng, Xiaoke Hao   +4 more
wiley   +1 more source

Red Cell Pyruvate Kinase Deficiency With Hypertriglyceridemia: A Case Report. [PDF]

Cureus
Hinge DV, Muranjan M, Taksande A, Hampe P.   +3 more
europepmc   +1 more source

Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation

Small Science, EarlyView.
Tregs control immune tolerance but can also enable tumor escape. Nanomaterials can now expand or stabilize Tregs to treat autoimmunity and support transplantation or conversely disrupt tumor Tregs to boost antitumor immunity. We also discuss unintended Treg modulation by nanoparticles, safety and manufacturing challenges, and future translational ...
Yiyin Chen, Haibo Huang, Xiang Wang, Xinghao Yu, Ziyan Huang, Zhou Jin, Chen Chen, Yan Chen, Bruce R. Blazar, Yang Xu, Yunjie Lu   +10 more
wiley   +1 more source

Pyruvate kinase M2 modulates mitochondrial dynamics and EMT in alveolar epithelial cells during sepsis-associated pulmonary fibrosis. [PDF]

J Transl Med
Feng J, Huang X, Peng Y, Yang W, Yang X, Tang R, Xu Q, Gao Y, He Z, Xing S, Mei S.   +10 more
europepmc   +1 more source

PLoS One [PDF]

, 2009
Aivaliotis, M., Gnad, F., Macek, B., Mann, M., Oesterhelt, D., Reichelt, P.   +5 more
core  

Chirality‐Directed Strategy to Overcome Tumor Resistance to Cuproptosis and Enhance Cuproptosis‐Immunotherapy

Small Structures, EarlyView.
Chirality‐directed strategy designed by copper‐based nanoregulator (Cu‐D‐Car@HA) to potentiate collaborative cuproptosis‐immunotherapy by overcoming tumor resistance to cuproptosis highlights a materials‐based method for superior cuproptosis‐immunotherapy.
Hao Zhou, Xiaoyang Zhang, Yu‐Zhang Wang, Shi‐Man Zhang, Hong Chen, Xiao Yan, Chi‐Hui Yang, Wei‐Hai Chen, Xian‐Zheng Zhang   +8 more
wiley   +1 more source

How We Treat Hemolytic Anemia Due to Pyruvate Kinase Deficiency. [PDF]

Hematol Rep
Tama-Shekan S, Moreno V, Saba L, Chaulagain CP.   +3 more
europepmc   +1 more source

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

VIEW, EarlyView.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu, Dan Zhao, Lingyan Zhong, Jianxujie Zheng, Dongxue Zhang, Enhui Wu, Qian Shi, Liang Qiao, Ling Lin   +8 more
wiley   +1 more source

Targeting pyruvate kinase M2 for the treatment of kidney disease. [PDF]

Front Pharmacol
Chen DQ, Han J, Liu H, Feng K, Li P.
europepmc   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source