Results 281 to 290 of about 234,539 (335)

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, EarlyView.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source

Hemolytic anemia due to pyruvate kinase deficiency coexistent with the alpha thalassemia trait and chronic myeloid leukemia. [PDF]

Hematol Transfus Cell Ther
Shrestha N, Khurana H, Verghese R, Mishra Y.   +3 more
europepmc   +1 more source

PLoS One [PDF]

, 2009
Aivaliotis, M., Gnad, F., Macek, B., Mann, M., Oesterhelt, D., Reichelt, P.   +5 more
core  

Effects of Simulated Ocean Acidification on the Activity, Escape Response, and Muscle Physiology of Marine Threespine Stickleback (Gasterosteus aculeatus)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Rapidly increasing anthropogenic CO2 can impose physiological challenges for fish species that are thought to be tolerant. We tested the hypothesis that elevated pCO2 will affect the routine activity and escape response by affecting energy metabolism and/or the muscle physiology of coastal fish.
Gwangseok R. Yoon, Elissa Khodikian, Gary J. Ren, Cosima Porteus   +3 more
wiley   +1 more source

Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1. [PDF]

Front Pharmacol
Zhang Y, Wu X, Li R, Sui M, Li G, Fan S, Yang M, Liu Q, Liu X, Wu C, Li L.   +10 more
europepmc   +1 more source

Identification of Antibodies to Chondrocyte and Synoviocyte Antigens in Equine Osteoarthritis

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Innate immune responses within the joint are now known to play a key role in osteoarthritis (OA) pathogenesis. However, comparatively little is known regarding the role of adaptive immune responses in OA, and whether they may be important for initiating and sustaining progressive low‐level joint inflammation.
Peter Linde, Jade Kurihara, Lyndah Chow, Zoë J. Williams, Dean Hendrickson, Luke Bass, Steven Dow, Lynn M. Pezzanite   +7 more
wiley   +1 more source

Exploring the mechanism of Shenhua tablet alleviating renal injury by regulating macrophage glycolysis hypoxia-inducible factor-1α/ pyruvate kinase M2 signaling pathway in diabetic kidney disease mice. [PDF]

J Tradit Chin Med
Yuanchun C, Jiaxing J, Qingmin LI, Xiaohong Z, Xiaofei J, Weijuan G, Xiangmei C, Wentao YU.   +7 more
europepmc   +1 more source

Vitexin Attenuates the Growth and Glycolysis of Acute Myeloid Leukemia Cells by Suppressing the HIF‐1α‐Modulated YAP Pathway Under Hypoxic Conditions

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Vitexin, an apigenin flavone glycoside, exhibits antitumor activity against various cancers including leukemia. Hypoxia enhances glycolysis, thereby promoting tumor growth. In this study, we aimed to explore the effects of vitexin on hypoxia‐induced growth and glycolysis in acute myeloid leukemia (AML) cells and determine the underlying ...
Ping Wang, Jia‐Jia Zhang, Fang Zhang, Xiao‐Jie Qu, Hui Zhang   +4 more
wiley   +1 more source

Beyond adenosine triphosphate: unveiling the pleiotropic effects of pyruvate kinase activation in sickle cell anemia. [PDF]

Haematologica
Glenthøj A.
europepmc   +1 more source