Results 71 to 80 of about 491,749 (238)

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Differential in vitro infection of neural cells by astroviruses [PDF]

, 2019
Encephalitis remains a diagnostic conundrum in humans as over 50% of cases are managed without the identification of an etiology. Astroviruses have been detected from the central nervous system of mammals in association with disease, suggesting that this
Janowski, Andrew B, Klein, Robyn S, Wang, David   +2 more
core   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. [PDF]

, 2018
Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely ...
A Marusyk, AD Rouillard, Amir Reza Aref, AN Hata, Anika Elise Adeni, AR Aref, Brandon Piel, C Henke, Camilla Laulund Christensen, CD Carey, Christine Anne Lydon, CL Christensen, Cloud Peter Paweletz, D Gao, D Hanahan, D Miao, D Pan, D Peng, D Roulois, DA Barbie, DA Rhodes, David Allen Barbie, Debattama Rai. Sen, Diana Miao, DJ Konieczkowski, DP Tabassum, DR Sen, EB Chuong, Evisa Gjini, Ewa Sicinska, F Perocchi, G Bindea, Gao Zhang, Hideki Terai, Hideo Baba, Hideo Watanabe, I Canadas, I Tirosh, Israel Cañadas, J Barretina, J Calbo, J Chen, Jacob Sands, JG Doench, Jong Wook Kim, JT Poirier, JW Kim, KA Hoadley, KB Chiappinelli, Kwok Kin Wong, Lynnette Marie Sholl, Marco Campisi, Masayuki Watanabe, Meenhard Herlyn, MR Junttila, NE Sanjana, O Shalem, Pablo Tamayo, Ravindra Uppaluri, Rohit Thummalapalli, RT Manguso, Russell William Jenkins, RW Jenkins, Scott Rodig, Shohei Koyama, Shunsuke Kitajima, Thanh Uyen Barbie, Tian Tian, Timothy Hagan, Tran Thai, X Wu, Y Qiao, Yanan Kuang, Yanxi Zhang, Yu Imamura, Zhi Wei   +75 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. [PDF]

, 2014
Transcriptional elongation by RNA polymerase (Pol) II is essential for gene expression during cell growth and differentiation. The positive transcription elongation factor b (P-TEFb) stimulates transcriptional elongation by phosphorylating Pol II and ...
Ji, Xiaodan, Lu, Huasong, Luo, Kunxin, Zhou, Qiang   +3 more
core   +3 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Dimethyl sulfoxide improves sensitivity and specificity of RT-PCR and qRT-PCR amplification of low-expressed transgenes [PDF]

Archives of Biological Sciences, 2012
The expression of transgenes in a host plant may be low for a number of reasons. Both low expression and poor specificity of amplification were encountered during analysis of the expression of the Arabidopsis cytokinin oxidase/dehydrogenase (AtCKX1 ...
Trifunović Milana, Simonović Ana, Bogdanović Milica, Cingel A., Raspor M., Subotić Angelina, Dragićević M.   +6 more
doaj   +1 more source

MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2a as an important regulator of T helper 9 and regularoty T-cell differentiation [PDF]

, 2016
MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin‐9 (IL‐9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR‐15b and
Baumjohann, Chang, Chong, Clambey, Cobb, Dang, Dardalhon, Elyaman, Filipowicz, Gerlach, Goswami, Goswami, Goswami, Haraguchi, He, Jabeen, Kaelin, Keith, Kohlhaas, Lewis, Licona-Limón, Lu, Lu, Lukashev, McNamee, Muljo, Nakatsukasa, Noelle, Nowak, Pua, Purwar, Schmitt, Shi, Singh, Staudt, Veldhoen, Yao, Zhou   +37 more
core   +2 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source