Results 1 to 10 of about 14,981 (247)

The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer

Molecules, 2023
The naphthalene diimide compound QN-302, designed to bind to G-quadruplex DNA sequences within the promoter regions of cancer-related genes, has high anti-proliferative activity in pancreatic cancer cell lines and anti-tumor activity in several ...
Ahmed A. Ahmed, William Greenhalf, Daniel H. Palmer, Nicole Williams, Jenny Worthington, Tariq Arshad, Shozeb Haider, Effrosyni Alexandrou, Dilek Guneri, Zoe A. E. Waller, Stephen Neidle   +10 more
doaj   +1 more source

Development of a quadruplex PCR amplicon next generation sequencing assay for detection and differentiation of Bartonella spp.

Frontiers in Microbiology, 2023
The genus Bartonella includes a group of species that are associated with a wide range of mammalian species, including human. It is challenging to detect all Bartonella species using a single molecular target due to its high genetic diversity.
Ying Bai, Lynn M. Osikowicz, Andrias Hojgaard, Rebecca J. Eisen   +3 more
doaj   +1 more source

G-quadruplex targeting chemical nucleases as a nonperturbative tool for analysis of cellular G-quadruplex DNA

iScience, 2021
Summary: G-quadruplex structures are associated with various biological activities, while in vivo evidence is essential to confirm the formation of G-quadruplexes inside cells.
Zhen Yu, Amber L. Hendricks, James A. Cowan   +2 more
doaj   +1 more source

Genomic G-quadruplex folding triggers a cytokine-mediated inflammatory feedback loop to aggravate inflammatory diseases

iScience, 2022
Summary: DNA G-quadruplex is a non-canonical secondary structure that could epigenetically regulate gene expression. To investigate the regulating role of G-quadruplex, we devised an integrating method to perform the algorithm profiling and genome-wide ...
Xiaolin Wang, Shunlun Chen, Zhuoyang Zhao, Fan Chen, Yuming Huang, Xingyu Guo, Linchuan Lei, Wantao Wang, Yanxin Luo, Huichuan Yu, Jianru Wang   +10 more
doaj   +1 more source

ALU non-B-DNA conformations, flipons, binary codes and evolution [PDF]

Royal Society Open Science, 2020
ALUs contribute to genetic diversity by altering DNA's linear sequence through retrotransposition, recombination and repair. ALUs also have the potential to form alternative non-B-DNA conformations such as Z-DNA, triplexes and quadruplexes that alter the
Alan Herbert
doaj   +1 more source

Tricky Topology: Persistence of Folded Human Telomeric i-Motif DNA at Ambient Temperature and Neutral pH

Frontiers in Chemistry, 2020
i-Motifs are four-stranded DNA structures formed from sequences rich in cytosine, held together by hemi-protonated cytosine-cytosine base pairs. These structures have been utilized extensively as pH-switches in DNA-based nanotechnology.
Mahmoud A. S. Abdelhamid, Mahmoud A. S. Abdelhamid, Zoë A. E. Waller, Zoë A. E. Waller   +3 more
doaj   +1 more source

A Chimeric DNA/RNA Antiparallel Quadruplex with Improved Stability

ChemistryOpen, 2022
Nucleic acid quadruplexes are proposed to play a role in the regulation of gene expression, are often present in aptamers selected for specific binding functions and have potential applications in medicine and biotechnology.
Elaina P. Boyle, Dr. Levan Lomidze, Prof. Dr. Karin Musier‐Forsyth, Prof. Dr. Besik Kankia   +3 more
doaj   +1 more source

A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells

Molecules, 2020
The stabilisation of G-quadruplexes (G4s) by small-molecule compounds is an effective approach for causing cell growth arrest, followed by cell death. Some of these compounds are currently being developed for the treatment of human cancers.
Ahmed Abdullah Ahmed, Stephen Neidle
doaj   +1 more source

Evaluating RHAU140-CFP molecule for specific recognition of parallel DNA G-Quadruplex by the fluorescence spectrophotometer

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2023
Determination of G-quadruplex formation in DNA is required for the design of small molecules (drugs) targeting G-quadruplex. In previous studies, we used the fluorescent protein RHAU53-CFP capable of recognizing parallel G-quadruplex structures through a
Trương Thị Tinh Tươm, Nguyễn Viết Chánh, Phan Thị Phượng Trang, Đặng Thanh Dũng   +3 more
doaj   +1 more source

Structural Probes in Quadruplex Nucleic Acid Structure Determination by NMR

Molecules, 2012
Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleic acid structural studies by NMR. Four-stranded nucleic acid architectures studies increasingly benefit from a plethora of nucleotide conjugates for resonance assignments, the ...
Mateus Webba da Silva, Andreas Ioannis Karsisiotis   +1 more
doaj   +1 more source