Results 11 to 20 of about 14,981 (247)
G‐Quadruplex Nucleic Acids [PDF]
Journal of Nucleic Acids, 2010 2 pages.-- PMID: 20814544 [PubMed].-- PMCID: PMC2931383].
ERITJA R. +4 more
openaire +5 more sources
, 2011 Opposed to DNA quadruplex sequences, RNA quadruplexes are still less well characterized. On the other hand, RNA quadruplexes are found to be at least as stable as their DNA counterparts. They show the same dependence on metal ions but seem to be much more restricted with respect to the adopted conformations.
Halder, Kangkan, Hartig, Jörg S.
openaire +3 more sources
Role of Hfq in Genome Evolution: Instability of G-Quadruplex Sequences in E. coli
Microorganisms, 2019 Certain G-rich DNA repeats can form quadruplex in bacterial chromatin that can present blocks to DNA replication and, if not properly resolved, may lead to mutations. To understand the participation of quadruplex DNA in genomic instability in Escherichia
Virali J. Parekh +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 The primary role of apurinic/apyrimidinic (AP) endonuclease APE1 in human cells is the cleavage of the sugar phosphate backbone 5′ to an AP site in DNA to produce a single-strand break with a 5′-deoxyribose phosphate and 3′-hydroxyl end groups.
Anastasia T. Davletgildeeva +4 more
doaj +1 more source
Engineering Proceedings, 2023 Pathogens can be detected electrochemically by measuring guanine oxidation signals generated from RNA or DNA hybridized to a biosensor working electrode. However, the associated limit of detection (LOD) is not sufficiently low for widespread clinical use.
Neil Gordon, Raj Bawa, Garry Palmateer
doaj +1 more source
G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2011 G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures.
Raveendra I, Mathad, Danzhou, Yang
openaire +2 more sources
Molecules, 2023 Quadruplexes (GQs), peculiar DNA/RNA motifs concentrated in specific genomic regions, play a vital role in biological processes including telomere stability and, hence, represent promising targets for anticancer therapy. GQs are formed by folding guanine-
Nikoleta Kircheva +5 more
doaj +1 more source
Why are G-quadruplexes good at preventing protein aggregation?
RNA Biology, 2023 Maintaining a healthy protein folding environment is essential for cellular function. Recently, we found that nucleic acids, G-quadruplexes in particular, are potent chaperones for preventing protein aggregation.
Theodore J. Litberg +5 more
doaj +1 more source
Molecules, 2022 Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures have attracted enormous attention in the last few years, being the most ...
Núria Escaja +3 more
doaj +1 more source
Control of the polyamine biosynthesis pathway by G2-quadruplexes
eLife, 2018 G-quadruplexes are naturally-occurring structures found in RNAs and DNAs. Regular RNA G-quadruplexes are highly stable due to stacked planar arrangements connected by short loops.
Helen Louise Lightfoot +4 more
doaj +1 more source